Comparative bioavailability of a novel timed release and powder-filled glucosamine sulfate formulation – a multi-dose, randomized, crossover study

A randomized comparative study of safety and efficacy of immediate release glucosamine HCL and glucosamine HCL sustained release formulation in the treatment of knee osteoarthritis: A proof of concept study

“…A multi-dose comparative BA study by Basak M, 2004 using timed release and powder-filled glucosamine sulfate formulation showed that although the time to attain C max was delayed (4.13h) with time release glucosamine the excretion was less compared to powder-filled glucosamine. [18] In addition the AUC0-24 was more with timed release preparation compared to powder-filled glucosamine. A similar cross over, proof of concept BA study, carried out in eighteen healthy human volunteers showed that a single dose of 1,500 mg, immediate release formulation, got absorbed and eliminated faster during the first two hours itself, while sustained release formulation, showed elimination after 5 hrs with increase in residence time of glucosamine in blood.…”

“…[18] In addition the AUC0-24 was more with timed release preparation compared to powder-filled glucosamine. A similar cross over, proof of concept BA study, carried out in eighteen healthy human volunteers showed that a single dose of 1,500 mg, immediate release formulation, got absorbed and eliminated faster during the first two hours itself, while sustained release formulation, showed elimination after 5 hrs with increase in residence time of glucosamine in blood.…”

Scientific Opinion on the substantiation of a health claim related to glucosamine hydrochloride and reduced rate of cartilage degeneration and reduced risk of development of osteoarthritis pursuant to Article 14 of Regulation (EC) No 1924/2006

“…One human study reported on the bioavailability of two different formulations of glucosamine sulphate (Basak et al, 2004), but no endpoints related to cartilage degeneration were measured.…”

On the use of chondroitin sulfate, glucosamine sulfate and undenatured type II collagen for back and limb pain and osteoarthritis

“…Фармакокинетические исследования показали, что время достижения максимальной концентрации в крови (t max ) составляет 2-4 ч [40]. В открытом рандомизированном перекрестном исследовании 12 здоровых добровольцев получали ГС (однократно, в дозах 750; 1500 и 3000 мг).…”