Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment

Keilani, Chafik; Augstburger, Edouard; Robin, Mathieu; Beaugrand, Amélie; Orès, Raphaëlle; Sahel, José‐Alain; Ayello-Scheer, Sarah

doi:10.4274/tjo.galenos.2019.24294

Cited by 8 publications

(6 citation statements)

References 33 publications

(31 reference statements)

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“…Previous studies evaluating complications rates between Densiron68 and 1,000 centistoke silicone oil found cataract, raised IOP, inflammatory reaction, macular ERM, and emulsification in both groups, but these were not significantly different between the two agents 5 . One of the potential advantages of DensironXTRA compared to Densrion68 is the lower emulsification rate, as DensironXTRA contains high molecular weight components that are harder to breakup under shear stress 21 , 22 . In keeping with this, we found no oil emulsification amongst any of the cases included in our analysis with DensironXTRA as a short-term tamponade, which is lower than previously reported rates with Densiron68 (18.5–33%) 33 – 35 .…”

Section: Discussionmentioning

confidence: 99%

“…New generation of Densiron includes DensironXTRA, which has a lower viscosity (1200 cSt) than Densiron68, improving ease of injection with 25-gauge systems, and enhancing simplicity of removal with a lower emulsification rate 21 , 22 . Given the paucity of literature, it is difficult to establish the safety and efficacy of DensironXTRA in the management of complicated RRDs.…”

Section: Introductionmentioning

confidence: 99%

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Anatomical and functional outcomes of short-term DensironXTRA heavy silicone oil for rhegmatogenous retinal detachments: a comparative case series

Felfeli

Murtaza

Herman

et al. 2023

Sci Rep

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To assess the safety and efficacy of short-term DensironXTRA tamponade for repair of complicated rhegmatogenous retinal detachments (RRD). This is a retrospective consecutive case series of patients undergoing pars plana vitrectomy (PPV) with intravitreal DensironXTRA and a comparator group with gas (sulfur hexafluoride (SF6) or perfluoropropane (C3F8)) tamponades by a single surgeon between January 2017 and November 2020 at a tertiary care centre. A total of 121 eyes with DensironXTRA and 81 comparator eyes with a gas tamponade were included. The DensironXTRA group had a significantly higher number of cases with inferior breaks (82% vs. 48%; p < 0.0001) and a history of previous PPV for RRD (64% vs. 12%; p < 0.0001). DensironXTRA was removed after a median period of 70 (IQR: 48.5–105.5) days. There was similar anatomical success in both the comparator gas tamponade and DensironXTRA groups (98.8% vs. 97.5%, p = 0.6506). Although both groups experienced a significant improvement in visual acuity, this change was significantly higher in the comparator gas tamponade group versus DensironXTRA group (p = 0.0017). There was no significant change in IOP in the DensironXTRA group (mean difference − 0.7; 95% CI − 1.753 to 0.331, p = 0.1785). The rates of complications were low and not significantly different between the two groups. There was no evidence for central macular thinning with DensironXTRA compared to the contralateral eye without RRD as well as with DensironXTRA in situ versus after its removal. DensironXTRA is a promising short-term tamponade agent with good anatomical and functional outcomes and low rates of complications for the repair of complicated RRDs.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Anatomical and functional outcomes of short-term DensironXTRA heavy silicone oil for rhegmatogenous retinal detachments: a comparative case series

Felfeli

Murtaza

Herman

et al. 2023

Sci Rep

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“…Its chemical structure allows easy injection, especially with 25-gauge systems. It also allows easy removal and has a low emulsification rate [ 127 , 128 ]. HSO has been considered to have a higher risk factor of postoperative OH than standard SO [ 129 , 130 ].…”

Section: Late Onset Silicone Oil-induced Glaucomamentioning

confidence: 99%

Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review

Nicolai

Lassandro

Franceschi

et al. 2020

Vision

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Silicone oil represents the main choice for intraocular tamponade in cases of complicated retinal detachment surgery. The intraocular pressure of an eye filled with silicone oil could increase, driven by a variety of different forces, according to several mechanisms. Two main conditions have been highlighted, depending on the onset: early hypertension or late glaucoma. The different types of silicone oils and their physico-chemical properties are varied and may play a role in the determination of intraocular pressure rise. The current body of literature allows for the illustration and categorization of the incidence and risk factors, as well as the pathogenesis and the management of the early postoperative hypertension subtended by an open- and closed-angle, along with the late onset silicone oil-induced glaucoma. Understanding the leading actors on the stage of ocular pressure elevation concurrently with silicone oil application for retinal surgery could help in guiding the timely and appropriate course of treatment.

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“…It was chosen as one of the endotamponades in the HSO study 15. Anatomical success rates with Densiron 68 varies from 33.3% to 81.3% 7 15 16…”

Section: Introductionmentioning

confidence: 99%

Heavy silicone oil tamponade: a multicentre experience

et al. 2022

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ObjectiveTo report multicentred use of the heavy silicone oil Densiron 68 for anatomical reattachment following rhegmatogenous retinal detachment (RRD) repair and its associated complications.Methods and analysisPatients from seven vitreoretinal units within the UK that underwent RRD repair with Densiron 68 between January 2015 and December 2019 were identified. Primary outcome measures were primary and final reattachment rate, retained Densiron and failure rate. Secondary outcome measures were duration of tamponade, final visual acuity (VA) and complications of heavy silicone oil.Results134 eyes of 134 patients were involved in the study. Primary surgical success was achieved in 48.5%, while a final reattachment rate of 73.4% was observed. The mean duration of Densiron 68 tamponade was 139.5 days. Mean final VA was 1.01 (range 0–2.9). 8 eyes (6.0%) required long-term topical steroids for anterior uveitis, whereas none of the eyes required long-term pressure-lowering treatment. Emulsification rate was 10.7% (6 eyes).ConclusionThis is the largest real-world study on Densiron 68 in the UK. Densiron 68 facilitates tamponade of inferior retinal pathology and may be considered as an option for tamponade of inferior retinal pathologies.

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Comparative Biochemical Outcomes, Effectiveness and Tolerance of Densiron 68 and Oxane HD for the Management of Complicated Retinal Detachment

Cited by 8 publications

References 33 publications

Anatomical and functional outcomes of short-term DensironXTRA heavy silicone oil for rhegmatogenous retinal detachments: a comparative case series

Anatomical and functional outcomes of short-term DensironXTRA heavy silicone oil for rhegmatogenous retinal detachments: a comparative case series

Intraocular Pressure Rise Linked to Silicone Oil in Retinal Surgery: A Review

Heavy silicone oil tamponade: a multicentre experience

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