Comparative Cardiovascular Effects of Midazolam and Thiopental in Healthy Patients

Sedative-hypnotic effects of midazolam in goats after intravenous and intramuscular administration

“…In the previous investigation (Stegmann 1998) the heart rate increased signi¢cantly after IM midazolam administration and the goats were not separated from the rest of the group during the observation period. Midazolam may cause transient hypotension, and respiratory depression in man (Alexander et al1992) and as the barore-£ex is preserved, the increase in heart rate may be a re£ex response to decreased blood pressure (Lebowitz et al 1982). Further investigation is required to evaluate the cardiopulmonary e¡ects of midazolam in goats.…”

Respiratory and cardiovascular effects in relation to plasma levels of midazolam and diazepam.

“…Both midazolam and diazepam transiently depress the baroreflex function and decrease the sympathetic tone (Marty et al, 1986a). The reduction in MAP after midazolam induction in both healthy (Marty et al, 1986a;Lebowitz et al,1982) and ill patients (Marty et al, 1986b;Lebowitz et al, 1983) is reported to be 15-19% when measuring the blood pressure invasively, despite doses ranging from 0.15 to 0.30 mg kg'-1. This supports our findings of a maximal effect on blood pressure evoked by midazolam at lower, sedative doses with a maximum decrease on MAP of 18%.…”

Evaluation of Midazolam as an Intravenous Induction Agent for General Anaesthesia-Comparision with Thiopentone

“…We observed a significant fall of diastolic pressure from pre-induction to 2 nd minute of post-induction in the thiopentone group otherwise no significant fall of diastolic pressure was observed. Lebowitz, PW et al 17 in their research concluded that Midazolam is, then, as acceptable for induction of anaesthesia as thiopental from a hemodynamic point of view in ASA. class I and II patients.…”