Comparative case contamination: Three disinfection systems

McKenney, Curtis D.; Ajello, M.

doi:10.1016/0892-8967(91)90038-2

Cited by 14 publications

(3 citation statements)

References 13 publications

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“…37 These biofilms can form on the surface of a contact lens case and help the organisms contained within it to resist the biocides in the surrounding contact lens solution. 37,38 A study by Wilson et al 39 tested the efficacies of commercial soft contact lens disinfectant solutions on biofilms of Pseudomonas, Serratia, and Staphylococcus. They inoculated the lens cases, incubated them for 24 hr, and then either added the disinfectant solution immediately or allowed the lens cases to air dry for 10 hr, before adding the disinfectant solution.…”

Section: Contact Lens Case Contamination: Rates and Relevant Organismsmentioning

confidence: 99%

“…The overall contamination rate after 6 weeks was 28%, and the individual contamination rates for ReNu, OptiFree, and AOSept were 40%, 45%, and 0%, respectively. 38 The importance of the development of biofilms to ocular infection in contact lens wearers is evidenced by the fact that several studies have found microbial biofilms in contact lens cases belonging to patients exhibiting microbial keratitis and have directly linked these two factors. 4,40 -42 These biofilms may contain multiple species of organisms.…”

Section: Contact Lens Case Contamination: Rates and Relevant Organismsmentioning

confidence: 99%

See 1 more Smart Citation

Contact Lens Cases: The Missing Link in Contact Lens Safety?

Hall

Jones

2010

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Contact lens case contamination is a significant public health concern and may contribute significantly to the development of microbial keratitis in contact lens wearers. Patients should be reminded that they must clean and disinfect their lens cases daily, should avoid the use of tap water for rinsing them, must not top up their solutions, must take into careful consideration where and how the cases are stored during the time that lenses are being worn and that they must be replaced regularly. The adoption of these methods will substantially reduce the levels of contamination of cases with pathogenic microbes.

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Section: Contact Lens Case Contamination: Rates and Relevant Organismsmentioning

confidence: 99%

Section: Contact Lens Case Contamination: Rates and Relevant Organismsmentioning

confidence: 99%

Contact Lens Cases: The Missing Link in Contact Lens Safety?

Hall

Jones

2010

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…In another study, the effectiveness of disinfectants was tested on the prevention of biofilm formation for long and continuous storage times (6 weeks). The results showed that the contamination rate on the walls of the container is 40% if the storage takes place in solution with polyhexamethylene biguanide, 45% if storage is solution with polyquad, 0% with hydrogen peroxide storage, and 3% if neutralized with a metal catalyst [22].…”

Section: Discussionmentioning

confidence: 99%

Prevention of Pseudomonas aeruginosa Biofilm Formation on Soft Contact Lenses by Allium sativum Fermented Extract (BGE) and Cannabinol Oil Extract (CBD)

et al. 2019

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Two natural mixtures, Allium sativum fermented extract (BGE) and cannabinol oil extract (CBD), were assessed for their ability to inhibit and remove Pseudomonas aeruginosa biofilms on soft contact lenses in comparison to a multipurpose Soft Contact Lens-care solution present on the Italian market. Pseudomonas aeruginosa (ATCC 9027 strain) and Pseudomonas aeruginosa clinical strains isolated from ocular swabs were tested. Quantification of the biofilm was done using the microtiter plate assay and the fractional inhibitory concentration index was calculated. Both forms of Pseudomonas aeruginosa generated biofilms. BGE at minimal inhibitory concentration (MIC) showed inhibition percentages higher than 55% for both strains, and CBD inhibited biofilm formation by about 70%. The care solution at MIC inhibited biofilm formation by about 50% for both strains tested. The effect of BGE on the eradication of the microbial biofilm on soft contact lenses at MIC was 45% eradication for P. aeruginosa ATCC 9027 and 36% for P. aeruginosa clinical strain. For CBD, we observed 24% biofilm eradication for both strains. For the care solution, the eradication MICs were 43% eradication for P. aeruginosa ATCC 9027 and 41% for P. aeruginosa clinical strain. It was observed that both the test soft contact lenses solution/BGE (fractional inhibitory concentration index: 0.450) and the test soft contact lenses solution/CBD (fractional inhibitory concentration index: 0.153) combinations exhibited synergistic antibiofilm activity against most of the studied bacteria. The study showed that BGE and CBD have good effect on inhibition of biofilm formation and removal of preformed biofilms, which makes them promising agents that could be exploited to develop more effective care solutions.

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