Comparative characterization of two monoclonal antibodies targeting canine PD-1
Mikolaj Kocikowski,
Katarzyna Dziubek,
Katarzyna Węgrzyn
et al.
Abstract:Monoclonal antibodies targeting immune checkpoints have revolutionized oncology. Yet, the effectiveness of these treatments varies significantly among patients, and they are associated with unexpected adverse events, including hyperprogression. The murine research model used in drug development fails to recapitulate both the functional human immune system and the population heterogeneity. Hence, a novel model is urgently needed to study the consequences of immune checkpoint blockade. Dogs appear to be uniquely… Show more
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