Comparative clinical study of efficacy and safety of adapalene 0.1% gel versus benzoyl peroxide 2.5% gel for the treatment of acne vulgaris

Dubey, Anuradha; Amane, Hanmant

doi:10.18203/2319-2003.ijbcp20194279

Cited by 1 publication

(4 citation statements)

References 10 publications

(20 reference statements)

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“…This could help shape a final consensus regarding the efficacy of these two agents. As per our findings, Benzoyl peroxide was efficacious in 75% of the subjects, comparable to the local and international investigations conducted on the SOC population [ 15 , 16 ]. However, in contrast to a study by Dubey and Amane [ 16 ], our study found no difference in the efficacy of 0.1% adapalene and 4% benzoyl peroxide [ 15 , 16 ].…”

Section: Discussionsupporting

confidence: 91%

“…As per our findings, Benzoyl peroxide was efficacious in 75% of the subjects, comparable to the local and international investigations conducted on the SOC population [ 15 , 16 ]. However, in contrast to a study by Dubey and Amane [ 16 ], our study found no difference in the efficacy of 0.1% adapalene and 4% benzoyl peroxide [ 15 , 16 ]. In the follow-up term, benzoyl peroxide demonstrated a prompt deduction of inflammatory lesions identical to other investigations.…”

Section: Discussionsupporting

confidence: 91%

“…The adverse events reported with benzoyl peroxide were burning and dryness which can be attributed to the keratolytic qualities of this medicine but the main unfavourable effect with this agent was reported to be erythema. Identical adverse effects have been reported by different earlier studies as well, although the proportion in our study was lower compared to previous studies [ 16 , 17 ]. However, none of the side effects led to discontinuation of either drug in our study population and both drugs were largely well tolerated in our SOC cohort, with one medication failing to demonstrate supremacy over the other in terms of side effects and tolerability, in contrast to a recent Indian study [ 16 ].…”

Section: Discussionsupporting

confidence: 75%

“…With repeated application, the dryness and erythema thanks to adapalene were subsequently abated. This “period of sensitization” has also been noted in the research performed on lower Fitzpatrick skin types and the adverse effects largely subsided after 12 weeks of application [ 16 ]. The adverse events reported with benzoyl peroxide were burning and dryness which can be attributed to the keratolytic qualities of this medicine but the main unfavourable effect with this agent was reported to be erythema.…”

Section: Discussionmentioning

confidence: 65%

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Comparing the Efficacy of Topical 4% Benzoyl Peroxide Versus Topical 0.1% Adapalene for Treatment of Acne Vulgaris in Skin of Color Population: A South Asian Perspective

Ullah,

Muhammad,

Mehmood

et al. 2024

Cureus

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Introduction Acne vulgaris is one of the most common skin problems encountered in the dermatology department. It is a chronic, inflammatory disease of the pilosebaceous unit, clinically presenting with comedones, papules, pustules, nodules, and cysts. With its particularly high prevalence in the younger population, it has significant adverse sequelae on patient’s quality of life. At present, due to an enhanced understanding of the pathogenesis of acne, various therapeutic modalities are available. The current management strategies generally follow a systematic treatment escalation based on disease severity and treatment response. However meticulous choice of appropriate anti-acne medicine for the acne type is the key to the management plan. Starting with mild to moderate types of acne as per the Leeds photometric grading scale, the most useful topical agents include topical retinoids, benzoyl peroxide, and topical antibiotics while systemic therapies such as oral antibiotics or isotretinoin are generally reserved for moderate to severe acne treatment. The skin of color (SOC) population is a relatively neglected group concerning the optimum and safe management strategies in different dermatological conditions and acne is no different, where there remains a need for comparing the available topical modalities for appropriate drug selection in the treatment of mild to moderate acne in SOC population. Objective The objective of this study was to compare the efficacy of topical 4% benzoyl peroxide versus topical 0.1% adapalene in the treatment of acne vulgaris in the SOC population. Methods The participants were divided into two groups, groups A and B. A total of 64 patients of both genders, with acne vulgaris (duration > three months) were included in the study. In group A, 32 patients were administered topical 0.1% adapalene whereas, in group B, 32 patients were given topical 4% benzoyl peroxide. Both medicines were applied at night daily. Patients were called for follow-up after 12 weeks. In both groups, the final efficacy evaluation was done using the Global Acne Grading System (GAGS) score after 12 weeks of treatment period. Results In group A, the age ranged from 15 to 40 years with a mean age of 25.781±3.93 years while the duration of complaint was 5.843±1.27 months. GAGS score was 25.281±2.65 and mean BMI was 23.092±3.51 kg/m2. In group B, the mean age was 25.187± 4.06 years, the duration of complaint was 7.375±2.25 months, the GAGS score was 23.906± 2.60 while the mean BMI was 21.485±3.88 kg/m2. Efficacy in group A was noted in 25 (78.1%) patients as compared to 24 (75%) patients in group B (p =0.768). Conclusion The present study showed that the safety and efficacy of 0.1% adapalene the traditional drug 4% benzoyl peroxide in the SOC population was comparable.

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Section: Discussionsupporting

confidence: 91%