Comparative effect of ochratoxin A on inflammation and oxidative stress parameters in gut and kidney of piglets

Marin, Daniela Eliza; Gras, Mihail Alexandru; Palade, Laurentiu Mihai; Ţăranu, Ionelia

doi:10.1016/j.yrtph.2017.07.031

Cited by 46 publications

(30 citation statements)

References 43 publications

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“…Inflammation pathway in the intestine was also affected by OTA. The expression of inflammation-related cytokines (IL-8, IL-6, IL-17A, IL-12, and IL-18) was significantly ( P < 0.05) decreased in the intestine of the piglets exposed to the toxin (Marin et al, 2017 ). The alteration of immune system renders the gut vulnerability to infection.…”

Section: Gastrointestinal Tractmentioning

confidence: 99%

Mycotoxin: Its Impact on Gut Health and Microbiota

Liew

Sabran

2018

Front. Cell. Infect. Microbiol.

337

195

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The secondary metabolites produced by fungi known as mycotoxins, are capable of causing mycotoxicosis (diseases and death) in human and animals. Contamination of feedstuffs as well as food commodities by fungi occurs frequently in a natural manner and is accompanied by the presence of mycotoxins. The occurrence of mycotoxins' contamination is further stimulated by the on-going global warming as reflected in some findings. This review comprehensively discussed the role of mycotoxins (trichothecenes, zearalenone, fumonisins, ochratoxins, and aflatoxins) toward gut health and gut microbiota. Certainly, mycotoxins cause perturbation in the gut, particularly in the intestinal epithelial. Recent insights have generated an entirely new perspective where there is a bi-directional relationship exists between mycotoxins and gut microbiota, thus suggesting that our gut microbiota might be involved in the development of mycotoxicosis. The bacteria–xenobiotic interplay for the host is highlighted in this review article. It is now well established that a healthy gut microbiota is largely responsible for the overall health of the host. Findings revealed that the gut microbiota is capable of eliminating mycotoxin from the host naturally, provided that the host is healthy with a balance gut microbiota. Moreover, mycotoxins have been demonstrated for modulation of gut microbiota composition, and such alteration in gut microbiota can be observed up to species level in some of the studies. Most, if not all, of the reported effects of mycotoxins, are negative in terms of intestinal health, where beneficial bacteria are eliminated accompanied by an increase of the gut pathogen. The interactions between gut microbiota and mycotoxins have a significant role in the development of mycotoxicosis, particularly hepatocellular carcinoma. Such knowledge potentially drives the development of novel and innovative strategies for the prevention and therapy of mycotoxin contamination and mycotoxicosis.

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Section: Gastrointestinal Tractmentioning

confidence: 99%

Mycotoxin: Its Impact on Gut Health and Microbiota

Liew

Sabran

2018

Front. Cell. Infect. Microbiol.

337

195

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“…Because of its chemical stability and widespread distribution, OTA contamination of livestock feed is all but avoidable. The nephrotoxicity of OTA has been well established not only in fish, mice, chicken, and pigs, but in humans as well [33][34][35][36][37]. At low doses, OTA reduced the growth rate, kidney coefficient, feed consumption, and induced degenerative changes of kidney epithelium [35,38].…”

Section: Oxidative Medicine and Cellular Longevitymentioning

confidence: 99%

Selenium Yeast Alleviates Ochratoxin A-Induced Apoptosis and Oxidative Stress via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in the Kidneys of Chickens

Cao²,

Guo

et al. 2020

Oxidative Medicine and Cellular Longevity

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The purpose of this study was to investigate the protective effect and mechanism of yeast selenium (Se-Y) on ochratoxin- (OTA-) induced nephrotoxicity of chickens. A total of 80 one-day-old healthy chickens were randomly divided into 4 equal groups: control, OTA (50 μg/kg OTA), Se-Y (0.4 mg/kg Se-Y), and OTA+Se-Y (50 μg/kg OTA+0.4 mg/kg Se-Y). In the OTA chickens, differences in body weight, kidney coefficient, biochemical histological analysis, antioxidant capability, and the expression levels of the PI3K/AKT and Nrf2/Keap1 signaling pathway-related genes were observed. The levels of total superoxide dismutase (T-SOD), antioxidant capacity (T-AOC), catalase (CAT), and glutathione (T-GSH) significantly decreased, but the malondialdehyde (MDA) level of the kidneys significantly increased in the OTA treatment group. More importantly, treatment with Se-Y improved the antioxidant enzyme activities within the kidneys of chickens exposed to OTA. In addition, administration of OTA resulted in apoptosis and was associated with decreased expression of AKT, PI3K, and Bcl-2, which in turn enhanced expression of Caspase3, Bax, and P53. However, Se-Y improved the antioxidant defense system through activation of the Nrf2/Keap1 signaling pathway. Gene expression of Nrf2 and its target genes (HO-1, GSH-px, GLRX2, MnSOD, and CAT) was downregulated following OTA exposure. Conversely, Se-Y treatment resulted in a significant upregulation of the same genes. Besides, significant downregulations of protein expression of HO-1, CAT, MnSOD, Nrf2, and Bcl-2 and a significant upregulation of Caspase3 and Bax levels were observed after contaminated with OTA. Notably, OTA-induced apoptosis and oxidative damage in the kidney of chickens were reverted back to normal level in the OTA+Se-Y group. Taken together, the data suggest that Se-Y alleviates OTA-induced nephrotoxicity in chickens, possibly through the activation of the PI3K/AKT and Nrf2/Keap1 signaling pathways.

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“…Since the known molecular mechanisms underlying the pathogenicity and carcinogenicity of mycotoxin are mostly at the protein level, very few examinations on miRNAs (likely the aberrant expressed miRNAs) can be found for early diagnosis of acute toxicity induced by mycotoxin. -122, miR-34a, miR-192, miR-26b, miR-761, miR-21, miR-199a ZEA, AOH, 3-ADON, 15-ADON, AFB1, FB1 (Gazzah et al, 2013;Juan-García et al, 2015;Qian et al, 2016;Girard et al, 2008;Brzuzan et al, 2015;Zhao et al, 2014;Zhou et al, 2016;Amr et al, 2016) Breast cancer miR-21, let-7, miR-200c, miR-199a ZEA, OTA, AFB1, α-ZAL (Yip et al, 2017;Yu et al, 2005;Belhassen et al, 2015;Bian et al, 2017;Elghoroury et al, 2017;Xu et al, 2017) Colon carcinoma miR-378-3a, miR-21, miR-34a, miR-299-3p, miR-495, miR-199a-5p, miR-375, miR-136, miR-15a, miR-192 DON, ZEA (Bensassi et al, 2009;Abassi et al, 2016;Fang et al, 2017;Kara et al, 2015;Wang et al, 2017;Yan et al, 2017;Yuan et al, 2017;Brzuzan et al, 2015) Inflammation-related diseases miR-21, miR-130a, miR-132, miR-155, miR-221 ZEA, DON, OTA, Patulin (Fan et al, 2018;Tardivel et al, 2015;Marin et al, 2017;Kim et al, 2015;McDonald et al, 2015;Croston et al, 2018;Qi et al, 2014;Valencia-Quintana et al, 2014) Apoptosis-induced diseases…”

Section: Mycotoxins and Mirnasmentioning

confidence: 99%

“…Exposure to DON, even at low doses, could induce low-grade inflammation in mice in the absence of observable adverse effects (Tardivel et al, 2015). OTA has been associated with inflammation because it could affect the gene expression of markers for the signaling pathways involved in inflammation (Marin, Pistol, Gras, Palade, & Taranu, 2017). Patulin was found to induce inflammation disease (atopic dermatitis), with the increase of ROS regulated by Th2-mediating inflammatory cytokines (Kim, Lee, Lee, Kang, & Hong, 2015).…”

Section: Inflammation-related Diseasesmentioning

confidence: 99%

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

Xue

Sun‐Waterhouse

Wang

et al. 2018

Comp Rev Food Sci Food Safe

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Mycotoxins are contaminants commonly found in foods and represent a worldwide threat to human health and welfare. Efforts have been undertaken to reduce mycotoxins and their toxicity, including the introduction of good agricultural practices, appropriate food processing, specific biotransformation approaches, and pursue therapeutic agents to counteract mycotoxins. Efficient and predictive tools are required for investigations on mycotoxins and their toxicodynamics, and strategies for mycotoxin reduction. Gene expression and transcriptome analysis can unravel the mode of action, transformation and combined toxicity of mycotoxins, or mycotoxin's interactions with food components including dietary therapeutics, at the cellular level and from a molecular perspective. MicroRNAs (miRNAs) regulate endogenously and posttranscriptionally the expression of target genes and enzymes involved in physiological, disease and toxicological responses, and the metabolism of therapeutic agents. Accordingly, this review aimed to collect up‐to‐date information on (1) the regulatory role of miRNAs in mycotoxin‐initiated toxicological processes and (2) the protective role of active ingredients from plants on mycotoxin‐induced toxicity. Through such a review of published evidence, we found some common signal pathways involving miRNAs shared by these two types of biological events. This finding indicates the possibility of using miRNAs as biomarkers in assessing and controlling mycotoxins in food via cellular mechanisms.

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Comparative effect of ochratoxin A on inflammation and oxidative stress parameters in gut and kidney of piglets

Cited by 46 publications

References 43 publications

Mycotoxin: Its Impact on Gut Health and Microbiota

Mycotoxin: Its Impact on Gut Health and Microbiota

Selenium Yeast Alleviates Ochratoxin A-Induced Apoptosis and Oxidative Stress via Modulation of the PI3K/AKT and Nrf2/Keap1 Signaling Pathways in the Kidneys of Chickens

The Significance of Regulatory MicroRNAs: Their Roles in Toxicodynamics of Mycotoxins and in the Protection Offered by Dietary Therapeutics Against Mycotoxin‐Induced Toxicity

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