Comparative Effect of Repeated Ingestion of Difructose Anhydride III and Palatinose on the Induction of Gastrointestinal Symptoms in Humans

Tamura, Akiko; Shiomi, Takuya; Tamaki, Noriko; Shigematsu, Norihiro; Tomita, Fusao; Hara, Hiroshi

doi:10.1271/bbb.68.1882

Cited by 24 publications

(11 citation statements)

References 25 publications

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“…DFAIII has been manufactured and used as a food supplement, and this disaccharide is slowly fermented in human large intestine [8]. Nondigestible oligosaccharides generally produce some gastrointestinal symptoms when ingested in large doses in humans; however, the abdominal symptoms associated with DFAIII were comparable to those of palatinose [9].…”

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confidence: 99%

Difructose anhydride III promotes iron absorption in the rat large intestine

2010

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Difructose anhydride III promotes iron absorption in the rat large intestine

2010

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“…In contrast to almost all other non-digestible oligosaccharides, there was no assimilation of this sugar by Bifidobacterium (Kituclin et al, unpublished results). In previous studies employing a human breath H 2 test, we observed that DFAIII was barely fermentable (Tamura et al 2003(Tamura et al , 2004b. The ingestion of DFAIII by healthy subjects for 4 weeks did not significantly change the faecal denaturing gradient gel electrophoresis profile, although a change in profile was noted in some subjects with chronic constipation (Minamida et al 2004).…”

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confidence: 66%

“…These results suggest that fermentation properties are different between DFAIII and FOS. Moreover, it has previously been reported that, when measured by breath H 2 in human subjects, DFAIII is slowly fermentable (Tamura et al 2003(Tamura et al , 2004b, in contrast to FOS, which is rapidly fermented (Stone-Dorshow & Levitt, 1987). Characteristics of fermentation, especially the rapid fermentation of FOS, may be involved in the limited, time-dependent effect of FOS on the plasma equol concentration.…”

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confidence: 99%

Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats

Tamura,

Nishimukai,

Shigematsu

et al. 2006

Br J Nutr

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Equol, a derivative of daidzein produced by enterobacteria, has greater activity as a phyto-oestrogen compared with daidzein. Difructose anhydride III (DFAIII) is a newly manufactured non-digestible disaccharide with unique fermentation properties. The present study evaluated the prebiotic effects of DFAIII on equol production and on plasma cholesterol concentrations related to the changes in equol production. We compared plasma equol concentrations at 10.00 and 18.00 hours and faecal isoflavone excretion in three groups of seven rats (male Wistar-ST strain, 6 weeks old) fed a basal diet or a DFAIII or fructooligosaccharide (15/g diet) diet containing 1g soya isoflavone/g diet for 20d. Equol concentrations in the DFAIII group were higher than in the control and fructooligosaccharides groups, especially in the later phase of the light period (18.00 hours) throughout the experiment. Daizein and genistein concentrations did not change between the diet groups. The faecal ratios of equol:daidzein were very high in all groups, but the ratios were higher in the DFAIII group than the control and fructooligosaccharide groups on day 3, and this tendency continued throughout the experiment. On day 20, the plasma total cholesterol concentration was lowest in the DFAIII group. Additionally, the cholesterol concentrations were inversely correlated to plasma equol concentration in all the rats. In conclusion, DFAIII efficiently enhanced plasma equol concentrations, which may be associated with an increase in equol production and a decrease in equol degradation by enterobacteria. Higher plasma equol concentrations may contribute to the hypocholesterolaemic effect of DFAIII feeding.

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“…In a human study, repeated ingestion of DFA III at 5 g/day for 12 days did not show any harmful side effects. 33) Cecal SCFA (acetate, propionate, butyrate) contents (μmol/cecum) decreased after continuous feeding with HFS diet in both of the experiments. SCFA contents were restored overall by supplementing with DFA III, raffinose, and FOS, although these oligosaccharides had different impacts on individual SCFA levels.…”

Section: After 2 Weeksmentioning

confidence: 81%

Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet

Hira

Yanagihara

Koga

et al. 2017

Bioscience, Biotechnology, and Biochemistry

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We investigated the effects of dietary supplementation of difructose anhydride III (DFA III), raffinose (Raf), and fructooligosaccharides (FOS) on diet-induced obesity development. Male rats were fed normal or high-fat and high-sucrose (HFS) diet, with or without supplementing (3%) DFA III, Raf, or FOS, for 8 or 5 weeks. Supplementing DFA III to the HFS diet decreased energy intake compared to the non-supplemented HFS diet. Accordingly, body weight gain and fat accumulation reduced in DFA III-fed rats. Cecal acetate production and plasma glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY) were elevated in DFA III-fed rats, while Raf and FOS partially affected these parameters. These results demonstrate that DFA III has suppressive effect on excessive energy intake driven by the palatable obesogenic diet, possibly due to combined effects of increased anorexigenic factors such as cecal acetate production and GLP-1/PYY secretion.

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Comparative Effect of Repeated Ingestion of Difructose Anhydride III and Palatinose on the Induction of Gastrointestinal Symptoms in Humans

Cited by 24 publications

References 25 publications

Difructose anhydride III promotes iron absorption in the rat large intestine

Difructose anhydride III promotes iron absorption in the rat large intestine

Supplementation of difructose anhydride III enhanced elevation of plasma equol concentrations and lowered plasma total cholesterol in isoflavone-fed rats

Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet

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