Comparative effectiveness and safety of xiyanping with ribavirin for rotavirus enteritis therapy in childhood: A systematic review and meta-analysis

Abstract

p < 0.00001; p < 0.00001;, p < 0.00001}. Six studies reported adverse reactions, but there was no significant difference between xiyanping and ribavirin groups {OR = 1.44,

Crystal structure and anti-inflammatory and anaphylactic effects of andrographlide sulphonate E in Xiyanping, a traditional Chinese medicine injection

“…The molecular structure was illustrated in Figure 1 and the data such as partial bond lengths, bond angles and major dihedral angle data were listed in Table 1. It was clearly showed that A ring (C(1)-C(5), C(10)) was in a chair-shaped conformation and the atoms C (2) The finding of X-ray analysis was consistent with that from NMR spectrum and further confirmed that sulphation transformation of 1 was accompanied by the translocation of exocyclic D 8,17 into cyclic D 8,9 . The methyl at C(17) then yielded a coplanar conformation of C(6)-C(7)-C(8)-C(9) with an average deviation of 0.023 A and only 0.134 A away from the base C (17).…”

“…The anaphylactic potential is as one of the most common side effects of TCM injections and only a few random incidences of immediate hypersensitivity have been reported for Xiyanping. [9] The occurrence of immediate hypersensitivity is considered to be related to the direct stimulation of mast cells to release histamine and the FceRI receptor protein present on the surface of mast cells plays a crucial role in mediating immediate allergic reactions. [27][28][29] By using in silico molecular docking analysis of ligand-protein interaction with the common-used FceRI receptor, the anaphylactic potential was investigated for 1 and 2 in the present work.…”

“…Xiyanping is just a kind of TCM preparation for injection use made from 1 by sulphonation modification and has been reputed as a most effective alternative to antibiotics . With potent antibacterial and antiviral efficacy, good safety and especially no detectable antibiotic resistance, Xiyanping has been widely used in China for the treatment of bronchitis, tonsillitis, bacillary dysentery and other infectious diseases …”

“…[7] With potent antibacterial and antiviral efficacy, good safety and especially no detectable antibiotic resistance, Xiyanping has been widely used in China for the treatment of bronchitis, tonsillitis, bacillary dysentery and other infectious diseases. [8][9][10] Chemical studies have demonstrated that Xiyanping consists of various water-soluble derivatives of 1, including a C 19 -OH sulphated product andrographlide sulphonate E, namely sodium 9-dehydro-17-hydro-andrographolide-19yl sulphate (2), the most abundant sulphonate in Xiyanping with an average content near 1.0 mg/ml. [11][12][13] Several pharmacokinetic researches show that 2 has fairly high metabolic stability and could be rapidly absorbed and then distributed in tissues, [14][15][16][17][18] further indicating effective enhancement of sulphonation transformation on solubility and bioavailability.…”

Xiyanping Plus Azithromycin Chemotherapy in Pediatric Patients with Mycoplasma pneumoniae Pneumonia: A Systematic Review and Meta-Analysis of Efficacy and Safety

“…XYP displays potent antibacterial and antiviral effects but no detectable antibiotic resistance in clinical practice. Therefore, it is reputed as a most effective alternative to antibiotics and has been widely used in China by combination therapy to treat various infectious diseases, including bronchitis, tonsillitis, and bacillary dysentery [14, 15]. Several recent reports further demonstrated the clinical application of XYP plus AZM chemotherapy for the treatment of p-MPP [12, 16, 17].…”