Comparative effectiveness of generic nifedipine versus Adalat long‐acting nifedipine for hypertension treatment: A multi‐institutional cohort study

Tung, Ying-Chang; Lin, Chia‐Pin; Hsiao, Fu-Chih; Ho, Cheng-Ting; Hsu, Tzyy-Jer; Chu, You-Chia; Chen, Wen‐Jone; Chu, Pao‐Hsien

doi:10.1111/jch.14478

Cited by 3 publications

(1 citation statement)

References 31 publications

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“…In this retrospective cohort study, we used data from the Chang Gung Research Database (CGRD), which is a multi-institutional medical records database of the Chang Gung Memorial Hospital (CGMH) system ( 20 , 21 ). The CGMH system consists of 2 medical centers, 2 regional hospitals, and 3 district hospitals, covering 1.3 million patients or 6% of the population in Taiwan ( 22 ). The CGRD comprises records of all inpatient and outpatient visits and emergency services from the CGMH system and contains patient data on demographics, medical and nursing records, pharmacy details, laboratory data, and surgical or procedural reports.…”

Section: Methodsmentioning

confidence: 99%

High Triglyceride Variability Increases the Risk of First Attack of Acute Pancreatitis

et al. 2023

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INTRODUCTION: Hypertriglyceridemia is the third most common etiology of acute pancreatitis. Whether triglyceride variability, independent of absolute triglyceride levels, is a predictor of acute pancreatitis is unknown. METHODS:We identified 98,819 patients who were diagnosed with hyperlipidemia between January 1, 2007, and December 31, 2013, and had at least 1 triglyceride measurement annually for 4 consecutive years from the Chang Gung Research Database in Taiwan. Triglyceride variability, defined as variability independent of the mean, was calculated in the 4-year run-in period. The patients were stratified according to the quartiles of triglyceride variability and were followed until December 31, 2019, for first attack of acute pancreatitis. RESULTS:During a mean follow-up of 5.9 years, 825 (0.83%) patients were newly diagnosed with acute pancreatitis (14.1 events per 10,000 person-years; 95% confidence interval 13.2-15.1). Triglyceride variability was significantly associated with an increased risk of acute pancreatitis, independent of baseline triglyceride and mean triglyceride levels (hazard ratio, 1.28 [95% confidence interval 1.05-1.57] for the highest vs the lowest quartiles of triglyceride variability; P for trend 5 0.006 over the quartiles of triglyceride variability). Subgroup analysis showed that this association was more pronounced among the patients with a higher neutrophil-to-lymphocyte ratio (P for trend 5 0.022).

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Section: Methodsmentioning

confidence: 99%

High Triglyceride Variability Increases the Risk of First Attack of Acute Pancreatitis

et al. 2023

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Characterization of Alternative Starches and Its Effects on the In Vitro Dissolution of Capsules Containing Low Solubility Drugs (Ibuprofen and Nifedipine)

de Freitas Santos Júnior,

Carvalho Junior,

Teles Júnior

et al. 2024

Starch Stärke

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Biopharmaceutical applications of alternative starches (ASs), as excipients in capsules containing low solubility drugs (nifedipine and ibuprofen), from seeds of breadfruit (Artocarpus altilis), red‐jambo (Syzygium malaccense), jackfruit (Artocarpus heterophyllus Lam.), avocado (Persea americana), and yam rhizomes (Dioscorea spp.), are investigated. ASs are characterized by microscopic, thermal, and X‐ray diffraction (XRD) analysis. Dissolution profiles are traced and compared to the official starch (from corn) – soluble in hot water, particle size (2–32 µm) and amylose/amylopectin ratio (0.29–0.33). Microscopy analysis shows AS granules with tetrahedral and spherical/rounded shapes (average size of 21.45 µm). The amylose/amylopectin ratios of AS are: breadfruit (0.29–0.37), red‐jambo (0.25–0.29), jackfruit (0.28–0.37), avocado (0.33–0.43), and yam rhizomes (0.37–0.47). AS presents crystallinity patterns of types A, B, and C. Thermal analysis shows mass loss with dehydration – 303 and 373 K (30 and 100 °C) and degradation 525 and 626 K (252 and 353 °C). The release of nifedipine (≥80%, in 20 min) and ibuprofen (≥60%, in 30 min) are similar or superior to corn starch. Only AS obtained from avocado seeds fails to release nifedipine. This study contributes to the quality control of medicine and alternative bioproducts.

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Comparative effectiveness of generic nifedipine versus Adalat long‐acting nifedipine for hypertension treatment: A multi‐institutional cohort study

Tung

Lin

Hsiao

et al. 2022

J of Clinical Hypertension

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This retrospective multi‐institutional database analysis aimed to evaluate the blood‐pressure‐lowering efficacy and clinical outcomes of a generic versus brand‐name nifedipine for hypertension management. A total of 12 693 patients who were prescribed a generic or brand‐name nifedipine between January 1, 2011, and December 31, 2018, were identified from the Chang Gung Research Database of Chang Gung Memorial Hospitals, Taiwan. Among them, 2112 (21.4%) were prescribed generic nifedipine. After propensity score matching, both the generic and brand‐name groups consisted of 2102 patients. At a mean follow‐up of 3 years, the changes in office systolic (p for interaction = .791) and diastolic blood pressure (p for interaction = .689) did not differ significantly between the patients who received the generic and the brand‐name nifedipine. There was no significant difference between the two study groups regarding the composite of all‐cause mortality, acute myocardial infarction, stroke, coronary revascularization, or hospitalization for heart failure (hazard ratio 0.98, 95% confidence interval 0.85–1.13; p = .774). In conclusion, the generic nifedipine was comparable to its brand‐name counterpart regarding office blood pressure reduction and the composite cardiovascular outcome for the treatment of patients with hypertension.

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Comparative effectiveness of generic nifedipine versus Adalat long‐acting nifedipine for hypertension treatment: A multi‐institutional cohort study

Cited by 3 publications

References 31 publications

High Triglyceride Variability Increases the Risk of First Attack of Acute Pancreatitis

High Triglyceride Variability Increases the Risk of First Attack of Acute Pancreatitis

Characterization of Alternative Starches and Its Effects on the In Vitro Dissolution of Capsules Containing Low Solubility Drugs (Ibuprofen and Nifedipine)

Comparative effectiveness of generic nifedipine versus Adalat long‐acting nifedipine for hypertension treatment: A multi‐institutional cohort study

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