“…The eight studies included were published between 2008 and 2023 and consisted of three RCTs [13] , [14] , [19] and five NRIS (one with a control group and four single-arm studies) [12] , [20] , [16] , [17] , [18] . Seven studies were conducted in Brazil [12] , [13] , [14] , [16] , [17] , [18] , [19] and one in Argentina [20] . A total of 222 patients participated in the studies, of which 169 subjects were assigned to different EBTP and the rest to control groups, when appropriate.…”