Comparative effects of methanol leaf extract of Moringa oleifera and ascorbic acid on haematological and histopathological changes induced by subchronic lead toxicity in male wistar rats

Usman, A.; Kawu, M.U.; Shittu, Muftau; Saleh, Aminu; Jolayemi, Kelvin Olutimilehin; Ibrahim, Nuraddeen B.; Oyetunde, Joshua Seyi; Okoronkwo, Magdalene Ogbonneya

doi:10.1016/j.prmcm.2021.100031

Cited by 6 publications

(5 citation statements)

References 39 publications

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“…This is in agreement with Kucukler et al (2) who found hydropic degeneration in tubular epithelium, necrosis and mononuclear cell infiltration in interstitial areas after lead acetate administration. Usman et al (1) also stated tubular necrosis in the rat's kidneys of the lead treated group.…”

Section: Discussionmentioning

confidence: 91%

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The Possible Ameliorative Role of Chrysin and Zinc on Lead Acetate Induced Nephrotoxicity in Adult Albino Rats (Biochemical, Histological and Immunohistochemical study)

2024

The Egyptian Journal of Hospital Medicine

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Background and Objective: Chrysin has been used for suppression of inducible nitric oxide synthase. Zinc inhibits the production of oxygen-free radicals. This study aimed to assess the possible ameliorative role of chrysin and zinc on lead acetate nephrotoxicity. Material and Methods:The study involved forty-five adult male albino rats that were categorized into, control group, lead acetate group, chrysin-treated group, zinc-treated group and chrysin plus zinc-treated group. At the end of the study blood samples were collected by cardiac puncture for laboratory analysis of blood urea and creatinine. The kidneys were collected and subjected to biochemical analysis, histological and immune-histochemical study. Result: Lead acetate elevated the blood urea and creatinine level, the tissue malondialdehyde MDA level and reduced the level of antioxidant enzymes. It interrupted the normal histological structures of renal sections, elevated the main area percent of collagen fiber deposition, and P53 and TNF α positive immuno-reactivity. Both chrysin and zinc significantly declined the toxic effect of lead acetate in chrysin-treated group and zinc-treated group. Chrysin and zinc co-treatment has significantly decreased the blood urea and creatinine levels, malondialdehyde level, collagen fiber deposition, and P53 and TNF α positive immuno-reactivity and significantly increased the antioxidant enzyme levels compared to chrysin-treated group and zinc-treated group. Conclusion: Lead acetate induced serious renal injury. Chrysin and zinc alone improved the toxic changes of lead acetate. However, coadministration of chrysin and zinc have a powerful ameliorative effect than chrysin and zinc alone.

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Section: Discussionmentioning

confidence: 91%

“…Lead (Pb) is a heavy metal that considered as an environmental pollutant and toxic agent. The World Health Organization lists Pb as one of the most harmful ten materials that are dangerous to human health (1) .…”

Section: Introductionmentioning

confidence: 99%

The Possible Ameliorative Role of Chrysin and Zinc on Lead Acetate Induced Nephrotoxicity in Adult Albino Rats (Biochemical, Histological and Immunohistochemical study)

2024

The Egyptian Journal of Hospital Medicine

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“…Heavy metals toxicity is a serious global human health hazard ( Usman et al, 2022 , Desoky et al, 2020a ). The data from this trial concluded that Pb(C 2 H 3 O 2 ) 2 induced toxicity and increases in the biochemical profile and histopathological alterations in renal and hepatic tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Pb is employed in many industrial processes, including the manufacture of ammunition, batteries, metal outcomes (solder and pipes), X-ray shielding devices, gasoline, paints, lead-based paint, toys, and cosmetics ( Martin and Griswold, 2009 , Nag and Cummins, 2022 ). Pb may be absorbed from the integument; it is mostly uptaken from the respiratory and alimentary tracts, leading to neurological, immunological, respiratory, renal, cardiovascular, skeletal, hematological, embryonic, and reproductive disorders because of disrupting the equilibrium of the oxidant-antioxidant agents and causing inflammation in different tissues ( Guo et al, 2018 , Zwolak et al, 2019 , Usman et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice

Melebary

Elnaggar

2023

Saudi Journal of Biological Sciences

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“…TMs, due to their tendency to bioaccumulate, are found to be very hard to metabolize in an organism. Various studies reported that TMs can negatively influence a great spectrum of human organs such as the lungs [ 164 ], bladder [ 165 ], heart [ 166 , 167 ], kidney, and liver [ 168 ], and can be responsible for exhibiting anti-androgenic activity [ 169 ] and induce haematological and histopathological changes [ 170 ]. Therefore, TMs have been classified in the top 20 list of dangerous substances by ATSDR [ 171 ].…”

Section: Environment As a Source Of Bread Chemical Contaminantsmentioning

confidence: 99%

Chemical Contamination in Bread from Food Processing and Its Environmental Origin

Maher

Nowak²

2022

Molecules

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Acrylamide (AA), furan and furan derivatives, polycyclic aromatic amines (PAHs), monochloropropanediols (MCPDs), glycidol, and their esters are carcinogens that are being formed in starchy and high-protein foodstuffs, including bread, through baking, roasting, steaming, and frying due to the Maillard reaction. The Maillard reaction mechanism has also been described as the source of food processing contaminants. The above-mentioned carcinogens, especially AA and furan compounds, are crucial substances responsible for the aroma of bread. The other groups of bread contaminants are mycotoxins (MTs), toxic metals (TMs), and pesticides. All these contaminants can be differentiated depending on many factors such as source, the concentration of toxicant in the different wheat types, formation mechanism, metabolism in the human body, and hazardous exposure effects to humans. The following paper characterizes the most often occurring contaminants in the bread from each group. The human exposure to bread contaminants and their safe ranges, along with the International Agency for Research on Cancer (IARC) classification (if available), also have been analyzed.

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Comparative effects of methanol leaf extract of Moringa oleifera and ascorbic acid on haematological and histopathological changes induced by subchronic lead toxicity in male wistar rats

Cited by 6 publications

References 39 publications

The Possible Ameliorative Role of Chrysin and Zinc on Lead Acetate Induced Nephrotoxicity in Adult Albino Rats (Biochemical, Histological and Immunohistochemical study)

The Possible Ameliorative Role of Chrysin and Zinc on Lead Acetate Induced Nephrotoxicity in Adult Albino Rats (Biochemical, Histological and Immunohistochemical study)

Impact of Moringa oleifera leaf extract in reducing the effect of lead acetate toxicity in mice

Chemical Contamination in Bread from Food Processing and Its Environmental Origin

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