Comparative Efficacy of High vs. Low Dose Cabergoline Treatment Regimen in Inducing Fertile Oestrus in Anoestrous Dogs

Ajitkumar, G.; Praseeda, R.; Rajankutty, K.; Alex, P. C.

doi:10.3923/javaa.2010.1735.1738

Cited by 3 publications

(4 citation statements)

References 14 publications

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“…The better induction of oestrus in cabergoline treated group in this study was almost similar to the finding of Ajitkumar et al (2010). They found induction rate of 83.34 and 75.00% within 13.5 and 21 days by using respectively two doses of cabergoline @ 5 µg/kg and 1 µg/kg b.wt.…”

Section: Fertility Responsesupporting

confidence: 88%

Induction of Oestrus and Fertility Response using Bromocriptine, Cabergoline and eCG Plus hCG Treatment Protocols in Female Dogs

Bisen¹,

Shukla²,

Baghel³

et al. 2021

IJAR

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Background: Reproductive pattern of dog is quite different from other mammalian species. A major difference between canine and other mammalian species is that in dog oestrus period is followed by long inter-oestrus interval (period of sexual quiescence), described as monocyclic animal. There are several reproductive problems encountered by the dog breeders and pet owners causing prolonged whelping interval. Anoestrus is thought to be one of the undiagnosed ovarian disorders responsible for prolonged oestrus interval in canine. Anoestrus of variable duration (2 to 10 months) following each oestrus cycle in female dogs is frequently observed. The approaches for the management of reproductive problems due to ovarian disorders encountered by the dog breeders and pet owners needs to be explored to optimize whelping interval. Hence, the current study aimed to study the Induction of oestrus and fertility response using bromocriptine, cabergoline and eCG plus hCG treatment protocols in female dogs.Methods: The study was conducted in 28 apparently healthy female dogs at TVCC college of veterinary science and Animal Husbandry Jabalpur and at door step of pet owners or dog breeders during the period of 2018-19. Dogs used in the study were divided into small, medium and large breeds. Pomeranian and Pug breeds included under small breeds; German shepherd, Labrador, Siberian husky, Dalmatian, ND and Doberman under medium breeds whereas Great dane, Rottweiler, Bullmastiff and Saint Bernard included under large breeds. The animals were selected irrespective of breeds with the history of anoestrus up to two month or more after whelping. The selection of anoestrus dog was made based on the ratio of cells in vaginal cytology and serum progesterone estimation.Result: Our results shows that the oestrus and fertility response following hormonal treatments in anestrous female dogs was significantly (p less than 0.01) higher than the oestrus induction in all treatment groups (71.48% in Group-I, 85.70% in Group-II and 71.48% in Group-III) as compared to control (14.28%).The breeding was recorded in 83.33% of dogs in cabergoline treatment followed by 100% in eCG plus hCG and 80% in bromocriptine with the conception rates of 100%, 80% and 75%, respectively in three groups. Serum progesterone (P4) profile were statistically significant (P less than 0.05) in all the treatment groups (I, II and III), but not in control group and the exflotive veginal cytology were found significantly (P less than 0.05) higher in induced than the non-induced animals of same group.

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Section: Fertility Responsesupporting

confidence: 88%

Induction of Oestrus and Fertility Response using Bromocriptine, Cabergoline and eCG Plus hCG Treatment Protocols in Female Dogs

Bisen¹,

Shukla²,

Baghel³

et al. 2021

IJAR

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“…The two oral formulations which have been used are cabergoline at the dose of 5 μg kg −1 day −1 and bromocriptine at an increasing dose (up to 0.1 mg kg −1 day −1 ) until the appearance of proestrous signs. A reduced dosage of cabergoline (0.6 μg kg −1 day −1 ) was shown to be effective as well (Ajitkumar, Praseeda, Rajankutty, & Alex, ; Cirit et al., ). The duration of treatment varies from 8 to 40 days, and the efficacy of oestrous induction is highly associated with the stage of anestrus when the treatment is started (Van Haaften et al., ; Verstegen, Onclin, Silva, & Concannon, ).…”

Section: Oestrous Induction Options Mechanisms Of Action and Side Efmentioning

confidence: 99%

“…As shown for the efficacy regarding oestrous induction, the pregnancy rate is influenced by the stage of anestrus, in which the treatment is performed with better results if treatment takes place in late anestrus. Pregnancy rates of 70% to 100% have been obtained after oestrous induction using dopamine agonists (Ajitkumar et al., ; Cirit et al., ; Gobello, Castex, & Corrada, ; Günay, Günay, & Soylu, ; Shimatsu, ; Verstegen et al., ; Zöldág, Fekete, Csáky, & Bersényi, ). In a recent study, the administration of oestradiol benzoate (unauthorized in many countries due to severe side effects), 1 week before the start of cabergoline treatment, led to significant reduction of the time span until the onset of proestrus and showed a synchronizing effect.…”

Section: Oestrous Induction Options Mechanisms Of Action and Side Efmentioning

confidence: 99%

Manipulation of the oestrous cycle of the bitch—what works… for now

Maenhoudt

Santos

Fontbonne

2018

Reprod Domestic Animals

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Contents Manipulation of the oestrous cycle of the bitch is a common request of pet owners for different reasons. On one side, clients may be interested in temporally preventing oestrus until the bitch has finished the performance career, or to manage the kennel in the presence of a stud dog and to avoid undesirable breeding. Additionally, clients with no interest to use their animal for breeding, may, for ethical reasons, prefer to avoid elective surgery such as ovariectomy, to control reproduction. On the other side, clients may want to induce oestrus to better control the time of birth, to use a male with limited availability during a specific time, or to reduce the duration of the interoestrous interval in bitches with a long oestrous cycle (>8 months). Both these options for oestrous manipulation are based on hormonal treatments. For oestrous prevention, synthetic progesterone has been used since the 1960s. Induction of oestrus has been established with reliable results using dopamine agonists in the late 1980s and more recently using GnRH agonists. This review is focusing on the current and recently available treatments to manipulate the oestrous cycle in the bitch.

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“…Bitches ovulate only once or twice at any time of the year (3). Prolactin seems to play a role in canine inter-oestrus interval, possibly by affecting gonadotropin secretion and (or) ovarian responsiveness to gonadotropins (4). Prolactin secretion was suppressed by administration of dopamine agonists to shorten the duration of anoestrus (5).…”

Section: Introductionmentioning

confidence: 99%

Hormonal Profile of Iraqi Bitches During Various Physiological Stages.

Zaid¹

2017

Bas.J.Vet.Res.

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The study was conducted to investigate the success of inducted estrus and to track the hormonal levels during the estrus cycle, pregnancy and post-parturition in dogs. Ten females, aged 2-3 years and weighted 18-22 kg, were kept in cages at the College of Veterinary Medicine-University of Baghdad. Dogs were mated and tracked till they become conceive. Then, after one month of parturition, they treated with Bromocriptine (Parlodel) a dose of (0.05mg/kg/dog) twice daily to induce estrus. Eight dogs showed estrus and mated again with the same mature dogs. Blood serum was taken once a week from cephalic vein. Follicular Stimulating Hormone (FSH), Luteinizing hormone (LH), Estrogen and Prolactin were measured by using canine Gamma counter kits. In both, normal and induced estrus periods, FSH and LH hormone levels started to elevate in proestrus and estrus phases then they declined in pregnancy months and post-parturition. Estrogen and prolactin hormones had significant differences during the second month in the other non-responsive dogs. Estrogen levels indicated that the proestrus, estrus and treatment period showed higher significant differences (P<0.01) than anestrus period.

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Comparative Efficacy of High vs. Low Dose Cabergoline Treatment Regimen in Inducing Fertile Oestrus in Anoestrous Dogs

Cited by 3 publications

References 14 publications

Induction of Oestrus and Fertility Response using Bromocriptine, Cabergoline and eCG Plus hCG Treatment Protocols in Female Dogs

Induction of Oestrus and Fertility Response using Bromocriptine, Cabergoline and eCG Plus hCG Treatment Protocols in Female Dogs

Manipulation of the oestrous cycle of the bitch—what works… for now

Hormonal Profile of Iraqi Bitches During Various Physiological Stages.

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