Comparative efficacy of placental membrane and Healiguide™ in treatment of gingival recession using guided tissue regeneration

Mahajan, Rupali; Khinda, Paramjit Kaur; Shewale, Akhilesh; Ghotra, Komaldeep; Bhasin, Meenu Taneja; Bhasin, Prashant

doi:10.4103/jisp.jisp_88_18

Cited by 15 publications

(11 citation statements)

References 33 publications

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“…In GBR procedures, gingival tissue enhancement and adequate space maintenance are parameters fundamental for periodontal repair [ 29 , 30 ] Therefore, the membrane thickness should range from 0.2 to 0.5 mm [ 30 ] to provide adequate thickness [ 31 ] for tissue enhancement and space maintenance required for periodontal repair process [ 29 ]. Specifically, membranes 0.2 mm thick facilitate soft tissue manipulation and 0.4 mm is the material of choice among early-generation membranes [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, Ngoc Nguyen et al, in an in vitro study, assessed how the membrane derived from bovine pericardium induced and stimulated attachment, migration, and proliferation of human gingival fibroblasts [ 34 ]. The authors demonstrated how the extracellular matrix of the bovine pericardium membrane can provide adequate support, acting as a cell scaffold [ 31 , 33 ]. As bovine pericardium membranes showed significant biocompatibility with human fibroblasts, by stimulating their migration patterns they may be successfully applied as a guided biomembrane in periodontal reconstruction and regeneration, as suggested by several recent studies on this topic [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

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Proliferation and Morphological Assessment of Human Periodontal Ligament Fibroblast towards Bovine Pericardium Membranes: An In Vitro Study

et al. 2022

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Over the past decade regenerative branches of dentistry have taken on more and more importance, resulting in the development of performing scaffold materials. These should induce cell adhesion, support, and guide the tissues’ growth. Among the developed materials, we can include resorbable or non-membranes. The purpose of this study was to investigate the proliferation abilities and the attachment of human periodontal ligament fibroblasts (HPLIFs) over two bovine pericardium membranes with different thicknesses, 0.2 mm and 0.4 mm, respectively. These membranes have been decellularized by the manufacturer, preserving the three-dimensional collagen’s structure. The HPLFs were cultured in standard conditions and exposed to the tested materials. XTT was performed to assess cell proliferation, while light microscopy (LM) and scanning electron microscopy (SEM) observations assessed fibroblast morphology at different times (T1, T2, and T3). Proliferation assays have shown a statistically significant difference in growth at T1 (p < 0.05) in the cells cultured with a thicker membrane compared to the thinner one. LM analysis showed healthy fibroblasts in contact with the membranes, appearing larger and with a polygonal shape. SEM observation demonstrated thickening of the fibroblasts which continued to adhere to the membrane’s surface, with enlarged polygonal shape and developed filipodia and lamellipodia. These results showed a similar cell behavior over the two bovine pericardium membranes, demonstrating a cellular migration along and within the layers of the membrane, binding with membrane fibers by means of filopodial extensions. Knowledge of the effects of the collagen membranes derived from bovine pericardium on cellular behavior will help clinicians choose the type of scaffolds according to the required clinical situation.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Proliferation and Morphological Assessment of Human Periodontal Ligament Fibroblast towards Bovine Pericardium Membranes: An In Vitro Study

et al. 2022

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“…This property makes it unique and different from other native collagen membrane and is known to facilitate fibrogenesis over osteoconduction. The porosity is less than the penetrable size of epithelial cell during the initial healing period [ 26 ]. Jim-Charm Kim [ 27 ] expressed that the position of collagen membrane after extraction of impacted third molar diminished the complications post-operatively at the early stage and improved the initial healing of gingival soft tissues and periodontal defects.…”

Section: Discussionmentioning

confidence: 99%

Use of Collagen Membrane in the Treatment of Periodontal Defects Distal to Mandibular Second Molars Following Surgical Removal of Impacted Mandibular Third Molars: A Comparative Clinical Study

Kumari

Ramakrishnan

Devadoss

et al. 2021

Biology

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The study aims to assess the efficacy of using collagen membrane in the treatment of distal periodontal defects of mandibular second molars following the removal of mesioangularly or horizontally impacted mandibular third molars surgically. Forty sites in twenty patients with bilaterally impacted mandibular third molars (mesioangular or horizontal) were considered for the study. In 20 test sites (Group A), after surgical removal of the mandibular third molar, a resorbable collagen membrane barrier was placed on the distal aspect of the mandibular second molar to cover the post-surgical bone defect. In the other control 20 sites (Group B), the same surgical procedure was repeated without placing any membrane barrier. The clinical parameters recorded were Oral Hygiene Index Simplified (OHI-S), Probing pocket depth (PPD), Clinical attachment level (CAL), and radiographic assessment of alveolar bone level (ABL). OHI-S score of most of the patients was observed to be satisfactory. Group A was observed to achieve a statistically significant reduction in PPD, CAL, and ABL gain compared to Group B. The improvements indicated that the use of collagen membrane facilitates early wound stabilization and promotes primary closure of the defect. This recovery is achieved through its unique property to assist fibrinogenesis over osteoconduction. Further longitudinal studies are needed to confirm the present findings.

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“…The in vivo biodegradation of both membranes takes place 6–8 weeks postoperatively (Schliephake et al 1994,. Mahajan et al 2018…”

Section: Discussionmentioning

confidence: 99%

Impact of different regenerative techniques and materials on the healing outcome of endodontic surgery: a systematic review and meta‐analysis

2020

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Background Regenerative techniques are increasingly applied in endodontic surgery, but different materials used in regenerative techniques may have varying impacts on wound healing. Objectives This study evaluated the effects of different regenerative techniques and materials on the outcome of endodontic surgery. Participants: patients with persistent periapical lesions, treated with root‐end surgery. Control: endodontic surgery without the use of regenerative techniques/materials. Intervention: endodontic surgery with the use of regenerative techniques/materials. Outcome: combined clinical and radiographic results. Methods PubMed, Web of Science, Embase, SinoMed and the CENTRAL Cochrane were searched up to 10th July 2020, followed by a manual search. Detailed eligibility criteria were applied. Cochrane’s risk‐of‐bias tool 2.0 was used to assess the risk of bias of the eligible studies. Meta‐analysis was conducted using RevMan software. Subgroup analyses were performed based on the regenerative materials used in endodontic surgery. Results Eleven eligible randomized controlled trials (RCTs) were included in the meta‐analysis: two had a low risk of overall bias, and nine had some concerns of overall bias. Generally, the use of regenerative techniques significantly improved the outcome of endodontic surgery (risk ratio [RR]: 0.42; 95% confidence interval [CI], 0.26–0.68; P < 0.001). On subgroup analysis, the use of expanded polytetrafluoroethylene (e‐PTFE) membranes alone had no added benefits (RR: 2.00; 95% CI, 0.22–18.33; P = 0.54). The application of collagen membranes or autologous platelet concentrates (APCs) alone was associated with a trend for better outcomes (RR: 0.51; 95% CI, 0.20–1.25; P = 0.14) (RR: 0.55; 95% CI, 0.18–1.71; P = 0.30). The combined use of collagen membranes and bovine‐derived hydroxyapatite significantly improved the outcome (RR: 0.35; 95% CI, 0.17–0.75; P = 0.007). Discussion This systematic review evaluated the effects of collagen membranes, e‐PTFE membranes, APCs and bone grafting materials, providing detailed information about the risks and benefits of using each regenerative technique/material or its combination in endodontic surgery. Conclusions Regenerative techniques improve periapical lesion healing after endodontic surgery. The combined use of collagen membranes and bovine‐derived hydroxyapatite may be beneficial as an adjunct to endodontic surgery. In contrast, the positive efficacy of e‐PTFE membranes or APCs alone remains doubtful.

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Comparative efficacy of placental membrane and Healiguide™ in treatment of gingival recession using guided tissue regeneration

Cited by 15 publications

References 33 publications

Proliferation and Morphological Assessment of Human Periodontal Ligament Fibroblast towards Bovine Pericardium Membranes: An In Vitro Study

Proliferation and Morphological Assessment of Human Periodontal Ligament Fibroblast towards Bovine Pericardium Membranes: An In Vitro Study

Use of Collagen Membrane in the Treatment of Periodontal Defects Distal to Mandibular Second Molars Following Surgical Removal of Impacted Mandibular Third Molars: A Comparative Clinical Study

Impact of different regenerative techniques and materials on the healing outcome of endodontic surgery: a systematic review and meta‐analysis

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