Comparative epidemiologic study of premalignant and malignant epithelial cutaneous lesions developing after kidney and heart transplantation

Euvrard, Sylvie; Kanitakis, Jean; Pouteil‐Noble, Claire; Dureau, G; Touraine, Jean Louis; Faure, Michel; Claudy, A; Thivolet, J

doi:10.1016/0190-9622(95)90239-2

Cited by 234 publications

(184 citation statements)

References 34 publications

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“…Solid graft transplantation is associated with an increased risk of neoplasms, essentially cutaneous carcinomas, and to a lower degree, lymphomas (1)(2)(3). In kidney graft recipients, the relative risk of development of skin carcinomas is 10 to 250 times higher than in matched controls (4).…”

Section: Introductionmentioning

confidence: 99%

Skin Carcinoma Arising From Donor Cells in a Kidney Transplant Recipient

et al. 2005

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The incidence of skin cancer is increased in transplant recipients. UV radiation, papillomaviruses, and immunosuppression participate in the pathogenesis of these tumors. In addition, donor cells may leave the grafted organ, reach peripheral tissues and either induce immune phenomena or possibly take part in tissue remodeling. Herein, we investigated the possible involvement of donor cells in the development of skin tumors in kidney allograft recipients. We analyzed a series of 48 malignant and benign cutaneous tumors developing in 14 females who had been grafted with a male kidney. The number of male cells was measured on microdissected material by quantitative PCR for Y chromosome. In the samples with high levels of male cells, fluorescent in situ hybridization (FISH) with X and Y probes and/or immuno-FISH with anticytokeratin antibodies were carried out. Male cells were detected in 5/15 squamous cell carcinomas and Bowen disease (range 4-180 copies), 3/5 basal cell carcinomas (91-645), 6/11 actinic keratosis (7-102), 2/4 keratoacanthoma (22-41), and 2/5 benign cutaneous lesions (14-55). In a basal cell carcinoma specimen with a high number of male cells, FISH showed that most cells within the tumoral buds were XY. In this lesion, immuno-FISH showed the presence of XY cytokeratin-positive cells indicating that the tumor nests contained male keratinocytes. In contrast, in other female transplants, male cells present in the tumors were not epithelial. In conclusion, stem cells originating from a grafted kidney may migrate to the skin, differentiate, or fuse as keratinocytes that could, rarely, undergo cancer transformation. (Cancer Res 2005; 65(5): 1755-60)

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Section: Introductionmentioning

confidence: 99%

Skin Carcinoma Arising From Donor Cells in a Kidney Transplant Recipient

et al. 2005

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“…Als Hauptgrund für dieses erhöhte Risiko wird die deutliche iatrogene Immunsuppression und unerwünschte Nebenwirkung der entsprechenden Medikamente diskutiert (Euvrard et al, 1995). Einige Autoren sahen einen Zusammenhang zwischen der Dosierungsmenge immunsuppressiver Medikamente und die aus dem Lebensalter hervorgehende natürliche Immunsuppression (Dantal et al, 1998;Hampton, 2005).…”

Section: % Wurde Für Die Lokalisation Am äUßeren Ohr Und In Der Perunclassified

Significance of parotid metastases of squamous cell carcinoma of scalp

2007

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“…In Europe, 40% of renal transplant recipients develop skin cancer within 20 years after grafting, (Hartevelt et al, 1990, Transplantation). Heart transplant recipients are at a higher risk than kidney transplant recipients, most probably due to the fact that they receive higher doses of immunosuppression agents (Euvrard et al, 1995, J Am Acad Dermatol) but it cannot be overlooked that the different types of immunosuppressive agents have different effects in this respect. Immunosupression as practised after organ transplantation does not increase the risk of developing BCC to the same extent as SCC.…”

Section: Immunosuppressionmentioning

confidence: 99%

“…SCC in transplant patients develop mostly on sun exposed sites (Bavinck et al 1993,Br J Dermatol. ) and are more frequent in individuals with fair skin, blue eyes, and blonde and red hair (Bavinck et al 1993,Br J Dermatol., Euvrard et al 1995, J Am Acad Dermatol, McLelland et al 1998; the standard risk factors for development of SCC. Early diagnosis and treatment of squamous cell cancers is important to avoid metastasis and tissue destruction as these cancers are more invasive and have a higher metastatic spread compared to basal cell cancers.…”

Section: Skin Cancer: Mechanisms and Human Relevance)mentioning

confidence: 99%