Comparative evaluation of avitene microcrystalline collagen hemostat in experimental animal wounds

Hait, M R; Robb, Charles Arthur; Baxter, Charles R.; Borgmann, Anna; Tippett, L.O.

doi:10.1016/0002-9610(73)90042-1

Cited by 52 publications

(29 citation statements)

References 3 publications

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“…[11,13] Fibrin/thrombin seal Fibrinogen is converted into fibrin monomers by thrombin; the monomers sponta neously polymerize and factor XIII induces covalent cross-linking to stabilized fibrin [24] sponge [1][2][3][4][5]9], This may be explained by their different abilities to promote platelet aggregation as shown in this study. However, there are some reservations when applying our results to in vivo conditions.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Local Hemostatics on Platelet Aggregation

Solheim¹,

Anfinsen²,

Holmsen³

et al. 1991

Eur Surg Res

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The platelets play an important role in the normal hemostasis, and it is known that both natural and synthetic macromolecules may induce platelet activation and aggregation. Thus, the purpose of the present study was to investigate the platelet aggregating effect of five different local hemostatics. Platelet aggregation was assessed by aggregometry. Unwoven fleece of bovine collagen polymer in fibrillar form induced aggregation in combination with small amounts of platelet agonists; ADP and adrenaline. Ordinary, nonabsorbable bone wax also induced aggregation in combination with the agonists, but larger concentrations of agonists were needed. Bioerodible polyorthoester with physical properties such as bone wax, oxidized cellulose and gelatin sponge did not promote platelet aggregation.

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Section: Discussionmentioning

confidence: 99%

“…Most research on local hemostatics con stitutes clinical investigations and animal studies, comparing bleeding time and blood loss [1][2][3][4][5][6][7][8][9][10]. There have been some investiga tions on the hemostatic mechanism of colla gen products and oxidized cellulose [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Effect of Local Hemostatics on Platelet Aggregation

Solheim¹,

Anfinsen²,

Holmsen³

et al. 1991

Eur Surg Res

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“…As a topical hemostatic, this collagen preparation is said to be superior to several commonly used substances [8], In addition, this form of collagen has been used successfully as a substrate for growth of tissue culture fibroblasts [21].…”

Section: Introductionmentioning

confidence: 99%

“…Collagen Hemostasis Platelet Coagulation Aggregation Adhesion A microcrystalline form of bovine collagen [2,7] is reported to be an effective topical hemostatic agent [8,24], This form of collagen has been tested in man and certain animals for its effect on hemostasis. As a topical hemostatic, this collagen preparation is said to be superior to several commonly used substances [8], In addition, this form of collagen has been used successfully as a substrate for growth of tissue culture fibroblasts [21].…”

Section: Introductionmentioning

confidence: 99%

Some Effects of a Microcrystalline Collagen Preparation on Blood

Mason¹,

Read²

1974

Pathophysiol Haemos Thromb

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Bovine microcrystalline collagen preparations are reported to be effective topical hemostatic agents. These collagen preparations shorten the clotting time of native blood. Platelets adhere to the microcrystalline collagen and appear to undergo the release reaction producing aggregation of nearby platelets. The hemostatic action of these collagen preparations appears to be exerted through their effects on platelets rather than through direct effects on soluble components of the intrinsic blood coagulation system.

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“…A preparation of microfibrillar collagen has been available since the early seventies as a topical hemostatic agent [1][2][3]. Since then, a water-insoluble hydrochloric acid salt of purified fibrous collagen from bovine chorium (Avitene R; Alcon (P.R.)…”

mentioning

confidence: 99%

In vitro Effect of a Microfibrillar Collagen Hemostat on Platelets

McClure

Duncan²,

Born³

et al. 1987

Pathophysiol Haemos Thromb

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Microscopic particles of microfibrillar collagen hemostat (MCH) have been shown to pass through a 40-μm blood transfusion filter. This study indicates that MCH passing through the filter retains a significant portion of its ability to aggregate platelets in vitro and the aggregating ability is dose related. The extent of platelet aggregation in the presence of the MCH filtrate or an ADP standard was measured photometrically and log dose-response curves constructed from the data. An ED₅₀ of 3.6 μg protein/ml platelet-rich plasma (PRP) was calculated at a protein concentration of 7.6 mg/ml in the MCH filtrate and an ED₅₀ of 5.9 μg protein/ml PRP at 12 mg/ml protein in the MCH filtrate. The platelet aggregating ability of the MCH filtrates corresponded to 18.8 and 39.6% of the maximum response produced by adenosine-5’-diphosphate. These findings support the view that blood contaminated with MCH should not be returned to a patient’s circulation.

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Comparative evaluation of avitene microcrystalline collagen hemostat in experimental animal wounds

Cited by 52 publications

References 3 publications

Effect of Local Hemostatics on Platelet Aggregation

Effect of Local Hemostatics on Platelet Aggregation

Some Effects of a Microcrystalline Collagen Preparation on Blood

In vitro Effect of a Microfibrillar Collagen Hemostat on Platelets

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