Comparative evaluation of cathepsin K levels in gingival crevicular fluid among smoking and nonsmoking patients with chronic periodontitis

Gajendran, Priya Lochana; Parthasarathy, Harinath; Tadepalli, Anupama

doi:10.4103/ijdr.ijdr_95_17

Cited by 14 publications

(13 citation statements)

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“…Once the hemostasis is destroyed, bone resorption will occur in periodontitis. In patients with chronic periodontitis, CatK levels were greatly elevated in smokers compared to nonsmokers, indicating a positive influence of smoking on CatK [108]. Moreover, CatK in GCF is not only derived from osteoclasts, but also from fibroblasts, macrophages, and gingival epithelial cells, contributing to the attachment loss and alveolar bone resorption [109].…”

Section: Involvement Of Cathepsin K In Immune Responsesmentioning

confidence: 99%

Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Periodontitis is an infectious disease whereby the chronic inflammatory process of the periodontium stimulated by bacterial products induces specific host cell responses. The activation of the host cell immune system upregulates the production of inflammatory mediators, comprising cytokines and proteolytic enzymes, which contribute to inflammation and bone destruction. It has been well known that periodontitis is related to systemic inflammation which links to numerous systemic diseases, including diabetes and arteriosclerosis. Furthermore, periodontitis has been reported in association with neurodegenerative diseases such as Alzheimer’s disease (AD) in the brain. Regarding immune responses and inflammation, cathepsin B (CatB) plays pivotal role for the induction of IL-1β, cathepsin K- (CatK-) dependent active toll-like receptor 9 (TLR9) signaling, and cathepsin S (CatS) which involves in regulating both TLR signaling and maturation of the MHC class II complex. Notably, both the production and proteolytic activities of cathepsins are upregulated in chronic inflammatory diseases, including periodontitis. In the present review, we focus on the roles of cathepsins in the innate and adaptive immune responses within periodontitis. We believe that understanding the roles of cathepsins in the immune responses in periodontitis would help to elucidate the therapeutic strategies of periodontitis, thus benefit for reduction of systemic diseases as well as neurodegenerative diseases in the global aging society.

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Section: Involvement Of Cathepsin K In Immune Responsesmentioning

confidence: 99%

Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis

Wang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…These are some of the previously undertaken research topics in the field of periodontology by Saveetha Dental College [20][21][22][23][24][25][26][27][28][29][30][31][32]. Now we are planning to do a comparative evaluation of intrinsic antibacterial activity of copper suction tube vs stainless steel suction tube against the S.mutans strains.…”

Section: Introductionmentioning

confidence: 99%

Comparative Evaluation of Inherent Antimicrobial Properties and Bacterial Surface Adherence between Copper and Stainless Steel Suction Tube

Ketkar

Malaiappan

Muralidharan

2020

JPRI

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Aim of the present study is comparative evaluation of the inherent antimicrobial properties of the copper and stainless steel suction tube also evaluate bacterial adherence and reduction with time within the suction tube. Present study was performed in an in vitro setting in Saveetha dental college and hospital. Both the metals suction tubes were cut into equal lengths of 2.3 inches and dipped in a sterile container for 5 minutes which had bacterial suspension of Streptococcus Mutans. Each group included three samples of copper and stainless steel suction tubes. Control group was taken out at 0 mins post initial dipping period de-coated in a sterile container and immediately cultured on Brain heart infusion agar, followed by group 1 at 15 minutes group 2 at 60 minutes and group 3 at 180 minutes respectively. Bacterial colonies were counted after overnight incubation. Copper suction tubes demonstrated less initial adhesion of bacterial colonies than that of stainless steel suction tubes. Percentage reduction in bacterial colonies was observed more in stainless steel suction tubes with respect to time. Spite of high initial adhesion stainless steel suction tube demonstrated higher degree of percentage reduction in bacterial colonies with time hence proven better for antimicrobial properties than copper suction tube.

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“…Various depigmentation techniques have been employed in the recent years. (Patil et al, 2015) Previously we have worked on plenty of topics in periodontology (ramesh, ravi and Kaarthikeyan, 2017;ravi et al, 2017;Arjunkumar, 2018;Gajendran, Parthasarathy and Tadepalli, 2018;Jain and nazar, 2018;Kavarthapu and Thamaraiselvan, 2018;ramesh et al, 2018Ezhilarasan, Apoorva and Ashok Vardhan, 2019;Kaarthikeyan, Jayakumar and Sivakumar, 2019;Kavarthapu and Malaiappan, 2019;Murthykumar, Arjunkumar and Jayaseelan, 2019;Vijayashree Priyadharsini, 2019). now we are planning to work on the knowledge and awareness on esthetic procedures in periodontics among undergraduate dental students.…”

Section: Introductionmentioning

confidence: 99%

Knowledge and Awareness About Esthetic Procedures in Periodontics Among Undergraduate Dental Students

Haripriya.¹

2020

Biosci. Biotech. Res. Comm

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The current level of awareness on beauty has driven a higher demand for aesthetic dentistry. The shape, position and appearance of the gingival tissue influences the aesthetics of the smile. Various techniques for gingival deformities have been introduced in recent years to meet the aesthetic needs of the patient with functional requirements. The aim of this study was to evaluate the knowledge and awareness about esthetic procedures in periodontics among undergraduate dental students. A 7-item questionnaire was prepared and circulated through an online portal among undergraduate dental students. A total of 100 students took up the survey among which 28 students were males and 72 students were females. The results obtained from the survey were tabulated, analysed and represented graphically using SPSS software (Version 23). Frequency distribution and percentage and chi-square test were done. In the present study, 86% of the undergraduate students were aware of gummy smile, 72% were aware of black triangle and 90% were aware of gingival hyperpigmentation. However, the knowledge on the treatment modalities for such conditions were inadequate. 48% were not aware of the treatment options for gummy smile, 42% were not aware of various gingival depigmentation techniques. Also, females had more knowledge and awareness as compared to males. This study emphasizes the need for more awareness about the esthetic procedures in periodontics must be created among undergraduate dental students.

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Comparative evaluation of cathepsin K levels in gingival crevicular fluid among smoking and nonsmoking patients with chronic periodontitis

Cited by 14 publications

References 0 publications

Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis

Involvement of Cathepsins in Innate and Adaptive Immune Responses in Periodontitis

Comparative Evaluation of Inherent Antimicrobial Properties and Bacterial Surface Adherence between Copper and Stainless Steel Suction Tube

Knowledge and Awareness About Esthetic Procedures in Periodontics Among Undergraduate Dental Students

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