Comparative evaluation of combined efficacy of methylene blue mediated antimicrobial photodynamic therapy (a-PDT) using 660 nm diode laser versus Erbium-chromium-yttrium-scandium-gallium-garnet (Er, Cr: YSGG) laser as an adjunct to scaling and root planing on clinical parameters in supportive periodontal therapy: A randomized split-mouth trial

Soundarajan, Subasree; Rajasekar, Arvina

doi:10.1016/j.pdpdt.2022.102971

Cited by 14 publications

(10 citation statements)

References 32 publications

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“…Their findings suggested the potential applicability of MB-PDT in controlling localized infections. While these results may not necessarily be perfectly extrapolated towards human participants, numerous clinical studies have supported their applicability [ 103 , 104 , 105 , 106 , 112 ]. For example, MB-PDT was successfully used in two diabetic patients suffering from osteomyelitis of the phalanges of their feet, having not responded well to conventional antibiotic therapy [ 112 ].…”

Section: Light-based Anti-infective Agents: Can They Overcome Antimic...mentioning

confidence: 99%

“…While originally developed as an antimalarial drug [ 96 ], its absorption potential at 660 nm makes it an efficient photosensitizer that can generate significant quantities of 1 O 2 . There are numerous studies that have exploited this to treat a multitude of different pathogenic microbes in vitro [ 97 , 98 , 99 , 100 ], in vivo [ 101 , 102 , 103 ], and even clinically in human patients [ 104 , 105 , 106 ]. In vitro , at radiant exposures as low as 10 J/cm 2 , coupled with concentrations of MB ≤ 150 uM, MB-PDT has been shown to significantly reduce the viabilities of Candida spp.…”

Section: Light-based Anti-infective Agents: Can They Overcome Antimic...mentioning

confidence: 99%

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Antimicrobial Resistance: Is There a ‘Light’ at the End of the Tunnel?

Leanse,

Marasini,

dos Anjos

et al. 2023

Antibiotics

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In recent years, with the increases in microorganisms that express a multitude of antimicrobial resistance (AMR) mechanisms, the threat of antimicrobial resistance in the global population has reached critical levels. The introduction of the COVID-19 pandemic has further contributed to the influx of infections caused by multidrug-resistant organisms (MDROs), which has placed significant pressure on healthcare systems. For over a century, the potential for light-based approaches targeted at combatting both cancer and infectious diseases has been proposed. They offer effective killing of microbial pathogens, regardless of AMR status, and have not typically been associated with high propensities of resistance development. To that end, the goal of this review is to describe the different mechanisms that drive AMR, including intrinsic, phenotypic, and acquired resistance mechanisms. Additionally, the different light-based approaches, including antimicrobial photodynamic therapy (aPDT), antimicrobial blue light (aBL), and ultraviolet (UV) light, will be discussed as potential alternatives or adjunct therapies with conventional antimicrobials. Lastly, we will evaluate the feasibility and requirements associated with integration of light-based approaches into the clinical pipeline.

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Section: Light-based Anti-infective Agents: Can They Overcome Antimic...mentioning

confidence: 99%

Section: Light-based Anti-infective Agents: Can They Overcome Antimic...mentioning

confidence: 99%

Antimicrobial Resistance: Is There a ‘Light’ at the End of the Tunnel?

Leanse,

Marasini,

dos Anjos

et al. 2023

Antibiotics

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“…The leading clinical indicators of PDT-assisted SRP treatment are the reduction of periodontal probing depth (PPD) and the increased level of CAL, defined as the difference between PPD and CAL levels in the baseline and follow-up periods, respectively. 84,85 Soundarajan et al 86,87 showed that the additional PDT could significantly improve the indicators of PPD, CAL, as well as plaque index (PI), gingival index (GI), and gingival recession (REC) than SRP alone in patients with periodontitis. Grzech-Lesniak et al 88 showed that multiple applications of PDT significantly improved bleeding on probing (BOP) compared with SRP alone, which also can be seen among geriatric patients TA B L E 2 Antibacterial effects of PDT on periodontal pathogens in vivo.…”

Section: Clinical Effects Of the Pdt-assisted Srpmentioning

confidence: 99%

“…The leading clinical indicators of PDT‐assisted SRP treatment are the reduction of periodontal probing depth (PPD) and the increased level of CAL, defined as the difference between PPD and CAL levels in the baseline and follow‐up periods, respectively 84,85 . Soundarajan et al 86,87 . showed that the additional PDT could significantly improve the indicators of PPD, CAL, as well as plaque index (PI), gingival index (GI), and gingival recession (REC) than SRP alone in patients with periodontitis.…”

Section: Clinical Effect Of Pdt In the Treatment Of Periodontitismentioning

confidence: 99%

Photodynamic therapy in periodontitis: A narrative review

Nie,

Zhang,

Pathak

et al. 2024

Photoderm Photoimm Photomed

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BackgroundPeriodontitis, a chronic infectious disease, is primarily caused by a dysbiotic microbiome, leading to the destruction of tooth‐supporting tissues and tooth loss. Photodynamic therapy (PDT), which combines excitation light with photosensitizers (PS) and oxygen to produce antibacterial reactive oxygen species, is emerging as a promising adjuvant treatment for periodontitis.MethodsThis review focuses on studies examining the antibacterial effects of PDT against periodontal pathogens. It also explores the impact of PDT on various aspects of periodontal health, including periodontal immune cells, human gingival fibroblasts, gingival collagen, inflammatory mediators, cytokines in the periodontium, vascular oxidative stress, vascular behavior, and alveolar bone health. Clinical trials assessing the types of PSs and light sources used in PDT, as well as its effects on clinical and immune factors in gingival sulcus fluid and the bacterial composition of dental plaque, are discussed.ResultsThe findings indicate that PDT is effective in reducing periodontal pathogens and improving markers of periodontal health. It has shown positive impacts on periodontal immune response, tissue integrity, and alveolar bone preservation. Clinical trials have demonstrated improvements in periodontal health and alterations in the microbial composition of dental plaque when PDT is used alongside conventional treatments.ConclusionsPDT offers a promising adjunctive treatment for periodontitis, with benefits in bacterial reduction, tissue healing, and immune modulation. This article highlights the potential of PDT in periodontal therapy and emphasizes the need for further research to refine its clinical application and efficacy.

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“…One such minimally invasive dental laser device is the Waterlase iPlus (made in the USA in 2012), consisting of the Er,Cr;YSGG laser. It has been widely used in implants, hard tissue, soft tissue, and other crucial applications [ 6 ]. This laser system has not been used previously to determine the alteration of the bracket bond strength.…”

Section: Introductionmentioning

confidence: 99%

An In-Vitro Analysis of the Surface Treatment of Orthodontic Bracket Bases With Er,Cr:YSGG Laser and Its Effect on Shear Bond Strength

Raju,

George,

T. R.

2023

Cureus

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Introduction Shear bond strength is indispensable to prevent the debonding of orthodontic brackets. Lasers have been proven to alter the bond strength of orthodontic brackets, but their efficiency has not been validated in many trials. The study aimed to evaluate the impact of the Er,Cr:YSGG laser on the bases of orthodontic brackets and determine their bond strength with the enamel surface. Materials and methods The Waterlase iPlus (made in the USA in 2012), comprising an Er,Cr:YSGG laser, was used. Based on the surface treatment of brackets, two groups were assigned (n=10), comprising laser-treated and untreated bracket bases. The brackets were treated with the minimum laser intensity (50 Hz, 4.5 W). Then, the brackets of both groups were attached to the labial surfaces of previously extracted premolars, respectively. The shear bond strength of brackets (SBS) was assessed using the universal testing device, and the Adhesive Remnant Index (ARI) was also measured. An independent sample t-test was used to compare the bond strength between the laser-treated and untreated brackets. Results The mean bond strength of laser-treated and control group brackets was 5 MPa and 8.63 MPa, respectively. The laser-treated brackets showed lower bond strength than the control brackets, but the results were statistically insignificant (p=0.23). The ARI analysis stated that bond failures occurred mostly in the region of the bracket and adhesive interface. Conclusion Laser-etched bracket bases showed lesser shear bond strength than the untreated ones, though the difference was statistically insignificant.

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Cited by 14 publications

References 32 publications

Antimicrobial Resistance: Is There a ‘Light’ at the End of the Tunnel?

Antimicrobial Resistance: Is There a ‘Light’ at the End of the Tunnel?

Photodynamic therapy in periodontitis: A narrative review

An In-Vitro Analysis of the Surface Treatment of Orthodontic Bracket Bases With Er,Cr:YSGG Laser and Its Effect on Shear Bond Strength

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