Comparative Evaluation of Different Extraction Techniques for Separation of Artemisinin from Sweet Wormwood (Artemisia annua L.)

Banožić, Marija; Wronska, Aleksandra Weronika; Jakovljević, Martina; Aladić, Krunoslav; Jerković, Igor; Jokić, Stela

doi:10.3390/horticulturae9060629

Cited by 5 publications

(2 citation statements)

References 49 publications

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“…In addition, wormwood can treat serious gastrointestinal diseases caused by parasites such as pinworms, roundworms, and tapeworms. From a historical perspective, wormwood was once considered the preferred drug for treating intestinal worms, but due to the serious side effects associated with absinthe, it is no longer popular [ 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. In a 2017 research report, extracts of Artemisia absinthium were found to be effective in killing Hymenolepis nana in laboratory mice.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Application of Volatilized Wormwood Essence Derived Naturally into Green Insecticide

Jin,

Wang,

Liu

et al. 2024

Molecules

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Naturally occurring substances and their derivatives function as vital resources for pesticides that can be used in fields, such as insecticide production and fungicide development. As a botanical entity displaying multifaceted biological functions, wormwood has received thorough scrutiny across multiple sectors. The insect repellency potency combined with antibacterial and antifungal activities of wormwood position it as a potential candidate for prospective development into eco-friendly chemical pesticides. In this research, Wormwood essential oil was procured via ethanol water under ultrasonic scenarios and subsequently diluted with PEG 400 to formulate green chemical pesticides. The defensive efficacy of this green pesticide on plants was validated through 2 weeks of clustered plant growth experiments. Active constituents that exerted their effects were scrutinized by GC-MS. Furthermore, this green pesticide also displays efficacious effects on the prevention and management of aphids, exhibiting a dose-dependent relationship. 4-terpenol, eucalyptol, carvacrol, and L-borneol were identified by GC-MS as the predominant active constituents in this green chemical pesticide. Wormwood can be leveraged to develop green chemical pesticides, which can protect plants without contaminating the environment.

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Section: Introductionmentioning

confidence: 99%

Preparation and Application of Volatilized Wormwood Essence Derived Naturally into Green Insecticide

Jin,

Wang,

Liu

et al. 2024

Molecules

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“…The available research data indicate that the biologically active potential of the various Artemisia species is far from being fully studied, and their conventional applications do not utilize their properties fully. Therefore, the current investigations [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 ] of the chemical compositions and biological activity of the various Artemisia L. species hold particular significance and are experiencing a real surge as they are presently in the focus of bioorganic and bioanalytical chemistry. The chromatography–mass spectrometry technique is widely acknowledged as the most-appropriate and -informative approach for the analysis of extracts or essential oils, specifically their chemical compositions, due to its ability to combine high separation power with reliable mass spectrometry detection [ 56 ].…”

Section: Introductionmentioning

confidence: 99%

Five Different Artemisia L. Species Ethanol Extracts’ Phytochemical Composition and Their Antimicrobial and Nematocide Activity

Nikitin,

Fitsev,

Egorova

et al. 2023

IJMS

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Among the plants that exhibit significant or established pharmacological activity, the genus Artemisia L. deserves special attention. This genus comprises over 500 species belonging to the largest Asteraceae family. Our study aimed at providing a comprehensive evaluation of the phytochemical composition of the ethanol extracts of five different Artemisia L. species (collected from the southwest of the Russian Federation) and their antimicrobial and nematocide activity as follows: A. annua cv. Novichok., A. dracunculus cv. Smaragd, A. santonica cv. Citral, A. abrotanum cv. Euxin, and A. scoparia cv. Tavrida. The study of the ethanol extracts of the five different Artemisia L. species using the methods of gas chromatography–mass spectrometry (GC–MS) and high-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (HPLC–MS/MS) allowed establishing their phytochemical profile. The obtained data on the of five different Artemisia L. species ethanol extracts’ phytochemical composition were used to predict the antibacterial and antifungal activity against phytopathogenic microorganisms and nematocidal activity against the free-living soil nematode Caenorhabditis elegans. The major compounds found in the composition of the Artemisia L. ethanol extracts were monoterpenes, sesquiterpenes, flavonoids, flavonoid glycosides, coumarins, and phenolic acids. The antibacterial and antifungal activity of the extracts began to manifest at a concentration of 150 µg/mL. The A. dracunculus cv. Smaragd extract had a selective effect against Gram-positive R. iranicus and B. subtilis bacteria, whereas the A. scoparia cv. Tavrida extract had a selective effect against Gram-negative A. tumefaciens and X. arboricola bacteria and A. solani, R. solani and F. graminearum fungi. The A. annua cv. Novichok, A. dracunculus cv. Smaragd, and A. santonica cv. Citral extracts in the concentration range of 31.3–1000 µg/mL caused the death of nematodes. It was established that A. annua cv. Novichok affects the UNC-63 protein, the molecular target of which is the nicotine receptor of the N-subtype.

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Recent cutting-edge approaches to the integration of solid-liquid extraction with deep eutectic solvents: Toward a greener procedure for biomass valorization

Wardani,

Samkumpim,

Alahmad

et al. 2024

Advances in Sample Preparation

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Comparative Evaluation of Different Extraction Techniques for Separation of Artemisinin from Sweet Wormwood (Artemisia annua L.)

Cited by 5 publications

References 49 publications

Preparation and Application of Volatilized Wormwood Essence Derived Naturally into Green Insecticide

Preparation and Application of Volatilized Wormwood Essence Derived Naturally into Green Insecticide

Five Different Artemisia L. Species Ethanol Extracts’ Phytochemical Composition and Their Antimicrobial and Nematocide Activity

Recent cutting-edge approaches to the integration of solid-liquid extraction with deep eutectic solvents: Toward a greener procedure for biomass valorization

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