Comparative evaluation of dissolution profile of drug in its formulation by UV spectrophotometry

Chaudhari, Rahul K.; Ganorkar, Anvesha V.; Dixit, Madhura P.; Umekar, Milind J.

doi:10.18231/j.ijpca.2020.004

Cited by 2 publications

(1 citation statement)

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“…Thiazine derivatives are the most important source of biologically active heterocyclic compounds. They exhibit ISSN 2056-9890 antimicrobial and anti-diabetic (Faidallah et al, 2011;Adly, 2012), anti-histaminic (Arya et al, 2012), antibacterial and antifungal (Tandon et al, 2006;Zia-ur-Rehman et al, 2009;Ganorkar et al, 2013), antagonistic (Galanski et al, 2006), antioxidant (Smith, 1951), analgesic and anti-inflammatory, (Chia et al, 2008;Tozkoparan et al, 2002) anti-tuberculosis (Koketsu et al, 2002), antitumor (Wang et al, 2012)), antimycobacterial (Indumathi et al, 2009) and antihelminthic and insecticidal (Smith, 1942) activity and act as potassium channel-opening agents (Erker et al, 2000), nitric oxide synthase inhibitors (Tung-Mei et al, 2005), smooth muscle relaxants (Schreder et al, 2000), urokinase inhibitors (Tanaka et al, 1998) and as as myocardial calcium channel modulators (Budriesi et al, 2002). Besides, thiazine derivatives are effective corrosion inhibitors for carbon steel in acidic media.…”

Section: Chemical Contextmentioning

confidence: 99%

Crystal structure and Hirshfeld surface analysis of a pyrrolo-thiazine complex

et al. 2021

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In the title compound, diethyl 2,2-dioxo-4-(thiophen-2-yl)-1-[(thiophen-2-yl)methyl]-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c][1,4]thiazine-1,3-dicarboxylate, C22H28NO6S3, the pyrrolo ring is in an envelope conformation while the thiazine ring adopts a near chair conformation. The dihedral angles between the thiazine ring and the methylthienyl, thienyl and pyrrolo rings are 64.0 (2), 87.92 (7) and 5.6 (2)°, respectively. In the crystal, the molecules are linked by weak C—H...O hydrogen bonds. A Hirshfeld surface analysis was performed to investigate the intermolecular interactions. Disorder of the methylthienyl group with site occupancies of 0. 792 (3) and 0.208 (3) is observed

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Section: Chemical Contextmentioning

confidence: 99%

Crystal structure and Hirshfeld surface analysis of a pyrrolo-thiazine complex

et al. 2021

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Analytical and Bioanalytical Methods for the Determination of Dipeptidyl Peptidase-4 Inhibitors in Various Matrices: A Comprehensive Review

Hadawale,

Sharma

2025

CDR

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Background:: DPP-4 inhibitors, or gliptins, are new oral antidiabetic drugs for type 2 diabetes. They help to regulate insulin and glucagon. These drugs have the advantage of a lower risk of hypoglycemia compared to some other diabetes medications and are typically prescribed when metformin and sulphonylureas have become less effective. Objective:: This review analyses a range of analytical and bioanalytical methods for DPP-4 inhibitors, that use spectroscopic techniques, chromatographic, and hyphenated techniques for analysis. So far, no review comprising all DPP-4 inhibitors has been presented. The primary objective of this review is to present the analysts with various analytical and bioanalytical methods for the quantification and estimation of DPP-4 inhibitors in different matrices. Methods:: To improve understanding, a review was carried out by creating a database of pre-existing research from digital sources such as ScienceDirect, and PubMed. The methodology is shown in the flowchart of the literature selection process. Conclusion:: The comprehensive assessment of methods for analysing DPP-4 inhibitors can be a valuable resource for researchers and healthcare practitioners. Hitherto, no review encompassing all DPP-4 inhibitors has been presented. Therefore, gaps in the data available on a particular subject, need to be required to collect data on a particular construct. The review suggests that chromatographic techniques were majorly used for analysis wherein solvents like acetonitrile, methanol, and buffer solutions were used as mobile phases that can deteriorate HPLC columns and equipment. So, scientists could investigate new methods for the assessment of DPP-4 inhibitors using more eco-friendly solvents.

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Comparative evaluation of dissolution profile of drug in its formulation by UV spectrophotometry

Cited by 2 publications

References 1 publication

Crystal structure and Hirshfeld surface analysis of a pyrrolo-thiazine complex

Crystal structure and Hirshfeld surface analysis of a pyrrolo-thiazine complex

Analytical and Bioanalytical Methods for the Determination of Dipeptidyl Peptidase-4 Inhibitors in Various Matrices: A Comprehensive Review

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