Comparative Evaluation of Hypoglycemic Properties of Raw And Boiled Allium cepa in Alloxan-Induced Diabetes Mellitus Rats

Ojieh, Anthony Emeka; Ugorji, AE; Ovuakporaye, I. S.; Ewhre, O. L.; Ossai, N. R.

doi:10.20510/ukjpb/4/i3/107860

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…Medicinal plants continue to provide valuable therapeutic agents, both in the modern and the traditional system. It is fascinating to observe how cultures that never came into contact with one another came to the same conclusions about the role of onions (Allium cepa) and garlic (Allium sativa) in health and disease states [ 13] .…”

Section: Discussionmentioning

confidence: 99%

Comparative Histological Study on the Effect of Allium Sativum (Garlic), Allium Cepa (Onion) & Insulin on Lingual Papillae of Diabetic Rats

Awwad

Rabbo

2020

Egyptian Journal of Histology

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Introduction: Diabetes mellitus (DM) is a common chronic metabolic disease. Various inflammatory diseases and soft tissue pathologies are associated with DM. Major concern in diabetes is oxidative stress. Antioxidants prevent diabetic complications. Onion & garlic are strong antioxidants, so this study was done to determine their possible effect in minimizing complications that diabetic patients suffer, compared to insulin. Materials and Methods: Fifty Albino rats were divided into 5 groups, ten rats each; Control, untreated streptozotocin induced diabetic group, diabetic insulin treated, diabetic garlic treated and diabetic onion treated groups. On the 21 st day of the experiment, rats were sacrificed and tongue specimens were prepared and examined by H&E for routine histological examination and by scanning Electron Microscope. Results: Histological changes of tongue papillae of diabetic untreated rats were observed, such as thinning of the epithelium of all papillae, numerous intra-epithelial cell vacuolations, thin detached keratin, extrcellular edema and inflammatory cell infiltrate within the lamina properia of all papillae. After, administration of insulin, garlic and onion, tongue papillae appeared almost normal compared to control group. However, the onion group displayed apparently slight better morphological and structural findings than garlic group. Discussion: Circumvallate papillae were most affected may be due to difference in their gustatory nerve supply. Other papillae in both garlic and onion treated groups, appeared almost normal. Which can be explained by the hypoglycemic, antimicrobial, anti-inflammatory effect of both extracts. Conclusion: Garlic and onion oral intake during early phases of diabetes caused valuable improvement of tongue papillae which was highly comparable to insulin treatment.

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Section: Discussionmentioning

confidence: 99%

Comparative Histological Study on the Effect of Allium Sativum (Garlic), Allium Cepa (Onion) & Insulin on Lingual Papillae of Diabetic Rats

Awwad

Rabbo

2020

Egyptian Journal of Histology

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“…Coffee, in the short-term, has been reported to produce increased blood sugar level; and some studies showed that over time, drinking coffee actually led to a decrease in blood sugar levels, including a reduced risk of type 2 diabetes [23,[57][58][59][60][61][62]. Meanwhile, the exact mechanism that governs the physiological regulation of coffee induced short-term production of raised blood sugar level, but significantly lower in the long term is still unclear.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Anti-Hyperglycaemic Potential of Allium Cepa, Coffee and Oxidative Stress

An¹

2018

IJBP

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Allium cepa Linn, botanicals, Liliaceae (family) commonly known as onion, and coffee are special delicacies, and conventional as functional foods that contain physiologically active ingredients that for centuries have been exploited as folk remedies for the treatment of diseases. The present study was conducted to evaluate the therapeutic efficacies and the possible participation of oxidative stress of Nigerian Allium cepa and coffee such as antioxidant, antihyperglycaemic, hypoglycaemic, hyperglycaemic in normal experimental wistar rats. Materials and Methods: qualitative phytochemical screening of hydromethanolic extract of Allium cepa was carried out for the identifications of the phytoconstituents. Hydromethanolic extract of Allium cepa 100mg kg -1, vitamin E 400mg kg -1, and coffee 500mg kg-1, combinations of Allium cepa and coffee and vitamin E and coffee respectively, administered orally to each group of rats daily. During the experimental periods glucose concentrations were estimated at baseline 0 (time of treatment ingestion), age 21 and 42 days respectively, with corresponded oxidative stress markers -superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and malondialdehyde (MDA) analyzed at age 42 days. Results:Result ranked time-dependent (in days) glucose lowering potential of treatments as: -Allium cepa + coffee > Allium cepa > vitamin E > coffee + vitamin E; with corresponded up regulated of SOD, CAT, GPx and GSH and reduced MDA. Conversely, coffee and control group (normal rats) significantly in time -dependent, raised blood glucose level with corresponded increase in MDA with respect to other biomarkers, suggesting lipid peroxidation oxidative stress induced impairment of cellular antioxidant protective system. Conclusion:It can be concluded that synergistic effect, presence of the additive bioactive phytoconstituents, and/or antioxidant efficacies or both, and potentiation action of several compounds in Allium cepa and coffee combined , over time, offer the intrinsic antioxidant defence system much better defensive mechanism to protect against free radicals, and alleviate the toxic effects of accumulation of reactive oxygen species (ROS); thence providing protective mechanisms against the development of elevated blood sugar levels. Evidently, Allium cepa and coffee combined is Research ArticleVolume 3 Issue 1

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Traditional and modern uses of onion bulb (Allium cepaL.): a systematic review

Teshika

Zakariyyah

Zaynab

et al. 2018

Critical Reviews in Food Science and Nutrition

178

107

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Onion, (Allium cepa L.), is one of the most consumed and grown vegetable crops in the world. Onion bulb, with its characteristic flavor, is the third most essential horticultural spice with a substantial commercial value. Apart from its culinary virtues, A. cepa is also used traditionally for its medicinal virtues in a plethora of indigenous cultures. Several publications have been produced in an endeavor to validate such traditional claims. Nonetheless, there is still a dearth of up-to-date, detailed compilation, and critical analysis of the traditional and ethnopharmacological propensities of A. cepa. The present review, therefore, aims to systematically review published literature on the traditional uses, pharmacological properties, and phytochemical composition of A. cepa. A. cepa was found to possess a panoply of bioactive compounds and numerous pharmacological properties, including antimicrobial, antioxidant, analgesic, anti-inflammatory, anti-diabetic, hypolipidemic, anti-hypertensive, and immunoprotective effects. Although a large number of in vitro and in vivo studies have been conducted, several limitations and research gaps have been identified which need to be addressed in future studies.

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Comparative Evaluation of Hypoglycemic Properties of Raw And Boiled Allium cepa in Alloxan-Induced Diabetes Mellitus Rats

Cited by 3 publications

References 17 publications

Comparative Histological Study on the Effect of Allium Sativum (Garlic), Allium Cepa (Onion) & Insulin on Lingual Papillae of Diabetic Rats

Comparative Histological Study on the Effect of Allium Sativum (Garlic), Allium Cepa (Onion) & Insulin on Lingual Papillae of Diabetic Rats

Evaluation of Anti-Hyperglycaemic Potential of Allium Cepa, Coffee and Oxidative Stress

Traditional and modern uses of onion bulb (Allium cepaL.): a systematic review

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