Comparative Evaluation of Ibuprofen/β-Cyclodextrin Complexes Obtained by Supercritical Carbon Dioxide and Other Conventional Methods

Hussein, Khaled; Türk, Michael; Wahl, Martin A.

doi:10.1007/s11095-006-9177-0

Cited by 64 publications

(51 citation statements)

References 21 publications

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“…Drug References geraniol, mustard oil [12] acetaminophen [13] piroxicam [14,15] miconazole [15,16,17,18,19,20] Eflucimibe [21,22] ibuprofen [23,24,25,26,27,28,29] naproxen [28,30,31,32] flurbiprofen [28] citral, thymol, carvacrol [33] imazalil [34] salicylic acid [35] azobenzene [36] budesonide [37,38,39] indomethacin [40] polyaniline [41] cholesterol [42] arylphosphines [43] itraconazole [44,45,46] 2 sodium salts [47] hydroxyflavone [48] benzocaine [50, 49,] bupivacaine, and mepivacaine [50] simvastatin [51] several triphenyl phosphine derivatives [52] all-trans-lycopene [53] 15 carbohydrates [54] human serum immunoglobulin G …”

Section: Resultsmentioning

confidence: 99%

Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide

Sauceau

Rodier

Fages

2008

The Journal of Supercritical Fluids

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Section: Resultsmentioning

confidence: 99%

Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide

Sauceau

Rodier

Fages

2008

The Journal of Supercritical Fluids

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“…By observing the scattering pattern from the non washed powder complex (IB-βCD) one finds all the peaks found in patterns (d) and (e) correspond to the inclusion complex and extra peaks that where registered along with peaks from IB (pattern b) corresponding to the free IB. The absence of peaks from non complexed βCD is caused by a low percentage of this component in the powder as discussed above [31,36,37]. …”

Section: -Indomethacinmentioning

confidence: 89%

The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity

Salústio

Feio

Figueirinhas³

et al. 2009

European Journal of Pharmaceutics and Biopharmaceutics

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The work aims to prove the complexation of two models drugs (ibuprofen, IB and indomethacin, IN) by beta-cyclodextrin (βCD), the effect of the water in such process, and the comparison of their complexation yields. Two methods were considered: kneading of a binary mixture of the drug:βCD and inclusion of either IB or IN in aqueous solutions of βCD. In the latter method the water was removed by air stream, spray-drying and freeze-drying. To prove the formation of complexes in final products optical microscopy, UV spectroscopy, IR spectroscopy, DSC, X-Ray and NMR were considered. Each powder was added to an acidic solution (pH = 2) to quantify the concentration of the drug inside βCD cavity. Others media (pH = 5 and 7) were used to prove the existence of drug not complexed in each powder as the drugs solubility increases with the pH. It was observed that complexation occurred in all powders, and that the fraction of drug inside the βCD did not depend neither on the method of complexation nor on the processes of drying considered.

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“…Thermal DSC analysis has been widely used to confirm formation of inclusion complex between drug and CD by comparing the thermal behaviours of the individual components and their binary systems [13,27] . DSC thermograms of IBU, β-CD, and their binary systems are shown in fig.…”

Section: Resultsmentioning

confidence: 99%

“…And both those drug candidates and marketed drugs will benefit from this technology [11] . Investigators have tried various methods to increase the drug loading ability of cyclodextrin, including drug ionization [12] , processing approaches [13] , addition of polymers [14,15] , cosolvents [16] .…”

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confidence: 99%

Effect of Drug Particle Size on Complexation, Physicochemical Properties and Dissolution of Cyclodextrin Inclusion Complexes

Ai¹,

Ma²,

Li³

et al. 2017

ijps

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Ai, et al.: Effect of Drug Particle Size on Cyclodextrin Inclusion ComplexesThe main purpose of this study was to investigate the role of drug particle size on the complexation, physicochemical properties and dissolution of β-cyclodextrin inclusion complexes. In this work, ibuprofen in size of 3 μm and 45 μm (ibuprofen 3 and ibuprofen 45) were employed as the poorly water-soluble drug model. Complexation kinetics and complexation efficiency studies were conducted to investigate the complexation of ibuprofen with β-cyclodextrin in water. The solid cyclodextrins inclusion complexes were prepared with kneading method and characterized by Fourier transform-infrared spectroscopy, differential scanning calorimetry, X-ray powder difractometry, optical microscopy analyses and dissolution test. Ibuprofen with smaller particle size showed higher complexation rate with β-cyclodextrin in complexation kinetics study. By comparing the apparent stability constant, K c and complexation efficiency of complexes, it also indicated that smaller drug particles are more efficient to interact with β-cyclodextrin than larger particles. The phase solubility diagram could be classified as Bs type, which denotes complexes with limited solubility. The Fourier transform-infrared spectroscopy, differential scanning calorimetry, X-ray powder difractometry and optical microscopy analyses confirmed the formation of β-cyclodextrin inclusion complexes with ibuprofen 3 or ibuprofen 45. In the dissolution study, the inclusion complexes presented faster dissolution rate on contrast with the physical mixtures and pure drugs. What is more, the inclusion complexes prepared with ibuprofen in small particle size showed improving dissolution rate than in large particle size.

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Comparative Evaluation of Ibuprofen/β-Cyclodextrin Complexes Obtained by Supercritical Carbon Dioxide and Other Conventional Methods

Abstract: This study presents the CPD-technique as a well suitable method to prepare a drug/beta-cyclodextrin complex with improved drug dissolution compared to the pure drug and materials obtained by other methods.

Cited by 64 publications

References 21 publications

Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide

Preparation of inclusion complex of piroxicam with cyclodextrin by using supercritical carbon dioxide

The influence of the preparation methods on the inclusion of model drugs in a β-cyclodextrin cavity

Effect of Drug Particle Size on Complexation, Physicochemical Properties and Dissolution of Cyclodextrin Inclusion Complexes

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