Comparative evaluation of infarct-limiting efficiency of postconditioning with lactate in ischemia-reperfusion of the myocardium in young and old rats and rats with transient hypercholesterolemia

Abstract

Taking into account the high medical and social significance of the problem of treating patients with coronary heart disease and acute myocardial infarction, the search for new effective methods of preventing or weakening ischemic and reperfusion myocardial damage and finding out the mechanisms of their implementation is an urgent task of modern experimental and clinical medicine. The aim of the study was to conduct a comparative analysis and clarification of features of the cardioprotective efficiency of postconditioning with lactate in ischemia-reperfusion of the myocardium in young and old rats and rats with transient hypercholesterolemia (HCE). It was found that remote ischemic postconditioning (RIPostC) in ischemia-reperfusion of the myocardium has an infarction-limiting effect and is accompanied by an increase in the level of lactate in the blood, and lactate after injection into the bloodstream of animals at a dose of 10 mg/kg 25 min after the start of reperfusion leads to a decrease in the size of the necrosis zone in the left ventricular myocardium in young and old rats. However, postconditioning with lactate is not effective in limiting the size of the zone of necrosis in the left ventricular of myocardium in young and old rats with transient HCE. There is reason to suppose that hyperlactatemia takes part in the realization of the cardioprotective effect of RIPostC. The presence of such a risk factor for cardiovascular diseases as HCE can serve as a criterion for excluding the use of postconditioning with lactate as a way to reduce ischemic and reperfusion damage to the myocardium in patients with acute myocardial infarction.