Comparative Evaluation of the Antimicrobial Efficacy of Octenidine Dihydrochloride with Contemporary Root Canal Disinfectants: A Systematic Review

Gulzar, Rukhsaar Akbar; Ajitha, P; Subbaiyan, Haripriya

doi:10.9734/jpri/2020/v32i1730669

Cited by 4 publications

(2 citation statements)

References 37 publications

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“…Root canal disinfectants were widely used to eliminate the microbes in root canals [ 7 ]. However, clinical root canal disinfectants, such as chlorhexidine acetate, cresol and formaldehyde solution, calcium hydroxide, possess inherent defects that bring risks to patients and affect their long-term applications [ 8 ]. Nowadays, nanomaterials have been widely used in EIs to inhibit bacteria in the root canals [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Fucoidan-derived carbon dots against Enterococcus faecalis biofilm and infected dentinal tubules for the treatment of persistent endodontic infections

et al. 2022

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Enterococcus faecalis (E. faecalis) biofilm-associated persistent endodontic infections (PEIs) are one of the most common tooth lesions, causing chronic periapical periodontitis, root resorption, and even tooth loss. Clinical root canal disinfectants have the risk of damaging soft tissues (e.g., mucosa and tongue) and teeth in the oral cavity, unsatisfactory to the therapy of PEIs. Nanomaterials with remarkable antibacterial properties and good biocompatibility have been developed as a promising strategy for removing pathogenic bacteria and related biofilm. Herein, carbon dots (CDs) derived from fucoidan (FD) are prepared through a one-pot hydrothermal method for the treatment of PEIs. The prepared FDCDs (7.15 nm) with sulfate groups and fluorescence property are well dispersed and stable in water. Further, it is found that in vitro FDCDs display excellent inhibiting effects on E. faecalis and its biofilm by inducing the formation of intracellular and extracellular reactive oxygen species and altering bacterial permeability. Importantly, the FDCDs penetrated the root canals and dentinal tubules, removing located E. faecalis biofilm. Moreover, the cellular assays show that the developed FDCDs have satisfactory cytocompatibility and promote macrophage recruitment. Thus, the developed FDCDs hold great potential for the management of PEIs. Graphical Abstract

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Section: Introductionmentioning

confidence: 99%

Fucoidan-derived carbon dots against Enterococcus faecalis biofilm and infected dentinal tubules for the treatment of persistent endodontic infections

et al. 2022

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“…The use of octenidine as an antiseptic agent has been widely studied. Its main uses include body washes for disinfection and prevention of (especially nosocomial) infections; 30 disinfection of surfaces and surgical material; 31 wound healing via impregnated dressings and bandage; 32 its use in dentistry as mouthwashes 33 for the treatment of gingivitis and other oral infections; 34 and its application for the treatment of vaginal infections. 35 However, no studies have been found on its use as a topical antiseptic to control overgrowth of S. aureus in skin with eczema or with an atopic tendency to prevent and reduce skin symptoms.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial properties and skin compatibility of a new emollient (body lotion) containing octenidine and silver citrate for atopic skin

Fernández,

Castany,

Gairí

2023

PPIJ

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Introduction:Emollients are the mainstay of nonpharmacologic treatment of atopic dermatitis and are considered critical in the care of skin with an atopic tendency to prevent the appearance of cutaneous symptoms. Its function is to improve hydration and restore skin barrier function, whose alteration leads to transepidermal water loss and facilitates excessive colonization by Staphylococcus aureus (S. aureus). We are presenting the first trials conducted with a new cosmetic emollient product containing octenidine and silver citrate as antimicrobial components. Material and methods:The following have been evaluated: in vitro antimicrobial capacity of the product against S. aureus, skin compatibility in subjects with sensitive skin (patchtest) and antimicrobial protection of the product (Challenge test). Results:In vitro studies demonstrated inhibition of S. aureus growth. After 48 hours of contact with the product under an occlusive patch, none of the subjects showed any signs of irritation. The effectiveness of the product's preservative system was confirmed in the Challenge test. Conclusions:The new cosmetic containing octenidine and silver citrate, specially designed for skin with an atopic tendency, thanks to its emollient and antimicrobial effect, has been shown to be effective for controlling the bacterial overgrowth of S. aureus characteristic of AD, without being an irritant and with good skin compatibility.

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New Insights Regarding the Use of Relevant Synthetic Compounds in Dentistry

Dumitrel,

Matichescu,

Dinu

et al. 2024

Molecules

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Worldwide, synthetic compounds are used for both in-office and at-home dental care. They are a valuable resource for both prophylactic and curative treatments for various dental problems, such as tooth decay, periodontal diseases, and many more. They are typically preferred due to their broad range of actions and ability to produce targeted, rapid, and long-lasting effects. Using a 0.12% chlorhexidine mouthwash is capable of reducing the plaque index from 47.69% to 2.37% and the bleeding index from 32.93% to 6.28% after just 2 weeks. Mouthwash with 0.1% OCT is also highly effective, as it significantly lowered the median plaque index and salivary bacterial counts in 152 patients in 5 days compared to a control group (p < 0.0001), while also reducing the gingival index (p < 0.001). When povidone-iodine was used as an irrigant during the surgical removal of mandibular third molars in 105 patients, it resulted in notably lower pain scores after 2 days compared to a control group (4.57 ± 0.60 vs. 5.71 ± 0.45). Sodium hypochlorite is excellent for root canal disinfection, as irrigating with 1% NaOCl completely eliminated the bacteria from canals in 65% patients. A 0.05% CPC mouthwash proved effective for perioperative patient care, significantly decreasing gingival bleeding (p < 0.001) and suppressing Streptococcus levels even one week post-surgery. Lastly, a 6% H2O2 paint-on varnish and 6% H2O2 tray formulations successfully bleached the teeth of 40 patients, maintaining a noticeably whiter appearance up to the 6-month follow-up, with significant color differences from the baseline (p < 0.005). Synthetic compounds have a large research base, which also provides a greater awareness of their mechanism of action and potential adverse effects. For a better understanding of how they work, several methods and assays are performed. These are protocolary techniques through which a compound’s efficacy and toxicity are established.

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Comparative Evaluation of the Antimicrobial Efficacy of Octenidine Dihydrochloride with Contemporary Root Canal Disinfectants: A Systematic Review

Cited by 4 publications

References 37 publications

Fucoidan-derived carbon dots against Enterococcus faecalis biofilm and infected dentinal tubules for the treatment of persistent endodontic infections

Fucoidan-derived carbon dots against Enterococcus faecalis biofilm and infected dentinal tubules for the treatment of persistent endodontic infections

Antimicrobial properties and skin compatibility of a new emollient (body lotion) containing octenidine and silver citrate for atopic skin

New Insights Regarding the Use of Relevant Synthetic Compounds in Dentistry

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