Comparative evaluation of the effectiveness and safety of two regimens of levonorgestrel for emergency contraception in Nigerians

Arowojolu, Ayodele O.; Okewole, Idris A.; Adekunle, Adeyemi O.

doi:10.1016/s0010-7824(02)00337-2

Cited by 101 publications

(69 citation statements)

References 15 publications

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“…In a World Health Organization (WHO) large randomized controlled trial (RCT) of these methods, delaying the first dose by 12 h increased the odds of pregnancy by almost 50% (Piaggio et al, 1999). In our study, the contraceptive efficacy of E-LNG-ECP was 95.3%, and the failure rate was 0.2%, significantly lower than failure rates in the RCTs of LNG conducted by WHO and other researchers (Ho et al, 1993; Task Force on Postovulatory Methods of Fertility Regulation,1998; Piaggio et al, 1999;Wu et al, 1999;Arowojolu et al, 2002;von Hertzen H et al, 2002;Ngai et al, 2005) (see Supplementary data, Table SI) In our study, 82.7% of participants took the drug during the first 24 h after unprotected intercourse, while only 42 -46% did so in the WHO RCT (von Hertzen H et al, 2002). Another study showed that the failure rates of ECPs during the first 24 h, 24 -48 h and 48 -72 h were 0.4, 1.2 and 2.7%, respectively (WHO, 1998).…”

Section: Discussioncontrasting

confidence: 51%

Efficacy and Safety of a Levonorgestrel Enteric-Coated Tablet as an Over- the-Counter Drug for Emergency Contraception: A Phase IV Clinical Trial

Chen

Xiang

Zhang

et al. 2011

Obstetrical &Amp; Gynecological Survey

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background: An enteric-coated levonorgestrel emergency contraceptive pill (E-LNG-ECP) is an improved formulation, in terms of side effects, which both dissolves and is absorbed in the intestine. Our aim was to evaluate the efficacy and safety of E-LNG-ECP as an over-the-counter (OTC) drug for emergency contraception (EC) in Chinese women.methods: A Phase IV clinical trial was conducted in five family planning clinics in China. Women seeking EC within 72 h after unprotected sexual intercourse or contraceptive failure who met the inclusion criteria were recruited. The efficacy of contraception (primary end-point was pregnancy rate), side effects (i.e. safety) and the value of E-LNG-ECP for EC were investigated.results: Of 2445 women (aged 15 -48 years) who took E-LNG-ECP with follow-up to determine pregnancy, only five pregnancies (0.2%) occurred. The efficacy of contraception was 95.3%. In total, 6.5% of women reported at least one adverse event after taking E-LNG-ECP, and no serious adverse events were reported. Only four subjects (0.16%) reported vomiting. The incidence of menstrual cycle disturbance was 20.1% after taking E-LNG-ECP. Subjects who had previously taken ECPs (54.4% of these women) rated the acceptability of E-LNG-ECP at 9.36 (on a 10-point scale) higher (P , 0.05) than the rating of other LNG-EC pills taken previously.conclusions: The study found that E-LNG-ECP was effective, safe and well tolerated as an OTC drug. However, an randomized controlled trial should be performed to compare standard LNG tablets with E-LNG-ECP.

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Section: Discussioncontrasting

confidence: 51%

Efficacy and Safety of a Levonorgestrel Enteric-Coated Tablet as an Over- the-Counter Drug for Emergency Contraception: A Phase IV Clinical Trial

Chen

Xiang

Zhang

et al. 2011

Obstetrical &Amp; Gynecological Survey

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“…Clinical effectiveness trials have found that LNG EC is more effective than the Yuzpe EC regimen (1,2). The actual effectiveness of LNG EC has been estimated between 58% and 95% under different delays in administration (1)(2)(3)(4)(5)(6). In some of the studies, a decrease of effectiveness with delay was noted, in others not.…”

mentioning

confidence: 99%

Levonorgestrel emergency contraception: a joint analysis of effectiveness and mechanism of action

Mikolajczyk

Stanford

2007

Fertility and Sterility

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“…Le taux d'échec global observé dans l'enquête que nous décrivons est similaire à ceux qui ont été publiés à partir d'étu-des en population générale [8][9][10] et légèrement supérieur à ceux observés dans des études cliniques strictement contrô-lées [3,11,14]. Dans cette enquête, 34 femmes (6,6 %) ont demandé la contraception d'urgence plus de 72 heures après un rapport sexuel non ou mal protégé.…”

Section: Discussionunclassified

Enquête prospective sur la délivrance de la contraception d'urgence dans les centres de planification et d'éducation familiale du Val-de-Marne

Gainer

Prudhomme²,

Perriot³

et al. 2005

Gynécologie Obstétrique & Fertilité

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Comparative evaluation of the effectiveness and safety of two regimens of levonorgestrel for emergency contraception in Nigerians

Cited by 101 publications

References 15 publications

Efficacy and Safety of a Levonorgestrel Enteric-Coated Tablet as an Over- the-Counter Drug for Emergency Contraception: A Phase IV Clinical Trial

Efficacy and Safety of a Levonorgestrel Enteric-Coated Tablet as an Over- the-Counter Drug for Emergency Contraception: A Phase IV Clinical Trial

Levonorgestrel emergency contraception: a joint analysis of effectiveness and mechanism of action

Enquête prospective sur la délivrance de la contraception d'urgence dans les centres de planification et d'éducation familiale du Val-de-Marne

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