2021
DOI: 10.3390/ani11082398
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Comparative Expression Analysis of Innate Immune Markers and Phagocytic Activity in Peripheral Blood of Dogs with Mammary Tumors

Abstract: Canine innate immune system role in cancer prevention and progression remains poorly understood. It has been revealed that innate immune cells could play a dual role in cancer immunology promoting or inhibiting tumor development and growth. Current immunotherapies target mainly the adaptive anti-tumor response and that may be a reason why they remain ineffective in a majority of patients. It is important to acquire detailed knowledge about innate immune mechanisms to broaden the diagnostic and therapeutic opti… Show more

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Cited by 2 publications
(2 citation statements)
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“…Macrophages show increased proliferation in the context of inflammatory diseases and, thus, elevated Ki-67 expression, which can lead to higher serum Ki-67 concentrations [42]. Monocytes lymphocytes, previously mentioned in the context inflammation, also play an important role in the cancer microenvironment, influencing tumour growth and progression [17,18,20].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Macrophages show increased proliferation in the context of inflammatory diseases and, thus, elevated Ki-67 expression, which can lead to higher serum Ki-67 concentrations [42]. Monocytes lymphocytes, previously mentioned in the context inflammation, also play an important role in the cancer microenvironment, influencing tumour growth and progression [17,18,20].…”
Section: Discussionmentioning
confidence: 99%
“…Another contributor to tumour growth and progression are inflammatory cells, for example neutrophils, lymphocytes, and monocytes play an important role in the cancer microenvironment of tumour tissue or behave differently in it compared to a healthy organism [17][18][19][20].…”
Section: Introductionmentioning
confidence: 99%