Comparative eye and liver differentially expressed genes reveal monochromatic vision and cancer resistance in the shortfin mako shark (Isurus oxyrinchus)

Domingues, Rodrigo Rodrigues; Mastrochirico-Filho, Vito A.; Mendes, Natália J.; Hashimoto, Diogo Teruo; Coelho, Rui; Cruz, Vanessa P.; Antunes, Agostinho; Foresti, Fausto; Mendonça, Fernando Fernandes

doi:10.1016/j.ygeno.2020.08.037

Cited by 3 publications

(2 citation statements)

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“…With the objective of clarifying the evolution of the vertebrate phototransduction cascade, RNA from the eyes of hagfish-Eptatretus cirrhatus, lampreys-Geotria australis and Mordacia mordax, elasmobranchs-Chiloscyllium punctatum, Carcharhinus amblyrhynchos, and Neotrygon kuhlii, bony fish-Amia calva, and gar-Lepisosteus platyrhincus [129] were sequenced and revealed that elasmobranchs have similar mechanisms of phototransduction cascade as the bony fishes, using GNAT1 together with PDE6, unlike, agnathostome that only has GNAT1. Regarding Isurus oxyrinchus, the transcriptomes of the eye were analyzed and there was an overexpression of the photoreceptor CRB1, which suggests that they utilize vision as their primary sense, and the expressed ocular opsin genes revealed a monochromatic vision on this species [130]. Furthermore, it has been suggested in S. canicular the reduction of growth in the retina due to a decreased expression of genes typically associated with cellular development and growth [131].…”

Section: Eyesmentioning

confidence: 99%

“…Moreover, peptides from C. plagiosum were already tested for their potential for liver regeneration studies [193]. Regarding Isurus oxyrinchus, the transcriptomes of the liver, showed that most of the genes expressed on this tissue had functions related to resistance to different cancers and other human diseases, such as HABP2 and PONs' genes [130].…”

Section: Livermentioning

confidence: 99%

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Decoding the Transcriptome of Sharks, Rays, and Chimaeras: Insights into Their Physiology, Morphology, Evolution, and Biomedical Applications

Seixas

Domingues

Antunes

2023

Fishes

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Chondrichthyes (including sharks, rays, and chimaeras) are a class of jawed cartilaginous fishes (with skeletons composed primarily of cartilage), with major relevance to the marine ecosystems and to humanity. However, cartilaginous fishes are facing various threatens, inflicting abrupt declines in their populations. Thus, critical assessment of available molecular genetic variation, particularly retrieved from Chondrichthyans' transcriptomic analyses, represents a major resource to foster genomics research in this ancient group of vertebrate species. Briefly, RNA-Seq involves the sequencing of RNA strands present on a target tissue, which can assist genome annotation and elucidate genetic features on species without a sequenced genome. The resulting information can unravel responses of an individual to environmental changes, evolutionary processes, and support the development of biomarkers. We scrutinized more than 800 RNA-Seq entries publicly available, and reviewed more than one decade of available transcriptomic knowledge in chondrichthyans. We conclude that chondrichthyans’ transcriptomics is a subject in early development, since not all the potential of this technology has been fully explored, namely their use to prospectively preserve these endangered species. Yet, the transcriptomic database provided findings on the vertebrates’ evolution, chondrichthyans’ physiology, morphology, and their biomedical potential, a trend likely to expand further in the future.

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Section: Eyesmentioning

confidence: 99%

Section: Livermentioning

confidence: 99%