Comparative Genome Analysis of the Daptomycin-Resistant<i>Streptococcus anginosus</i>Strain J4206 Associated with Breakthrough Bacteremia

Rahman, Maliha; Nguyen, Scott V.; McCullor, Kimberly A.; King, C.; Jorgensen, James H.; McShan, W. Michael

doi:10.1093/gbe/evw241

Cited by 9 publications

(6 citation statements)

References 72 publications

(43 reference statements)

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“…Streptococcus genus is frequently found in patients' tissues as well as in saliva. It is important to note the viridans group of the Streptococcus genus is usually present in oropharynx and gastrointestinal tract and genitals (28). Not too long ago it was associated with normal flora (29), however, this affirmation has been changing based on findings mainly focused on S. anginosus, where it has been implicated in upper digestive tract cancer (30).…”

Section: Discussionmentioning

confidence: 99%

Oropharyngeal Squamous Cell Carcinoma: Human Papilloma Virus Coinfection with Streptococcus anginosus

et al. 2019

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Introduction: Human papilloma virus (HPV) and oral bacteria capable of acetaldehyde production from ethanol, such as Streptococcus anginosus, Prevotella melaninogenica, and Fusobacterium naviforme are among oropharyngeal squamous cell carcinoma (OSCC) infectious risk factors. Objective: Determine associations with HPV and S. anginosus, P. melaninogenica, and F. naviforme in patients with and without OSCC. Methods: Presence of HPV and HPV-16 was determined in 26 patients with OSCC and 26 without OSCC by conventional PCR and simultaneous presence of S. anginosus, P. melaninogenica, and F. naviforme quantification through q-PCR. Statistical analysis was carried out using Pearson’s X² and Student’s-t test. Results: Patients with OSCC had HPV and HPV-16 frequencies of 84% and 61.5%, respectively, in contrast for patients without OSCC frequencies were 34.6 and 30.7%. P. melaninogenica, and F. naviforme microorganisms were not present in any participant in this study. S. anginosus frequency in patients with OSC was 38.4% and in patients without OSCC was 30.7%. Patients with OSCC had S. anginosus + HPV co-infection at a 38.4% frequency and S. anginosus + HPV-16 at a 23.1% frequency. For individuals without OSCC S. anginosus + HPV co-infection was 3.8% and S. anginosus + HPV-16 3.8%. A greater frequency of S. anginosus + HPV co-infection and S. anginosus + HPV-16 was observed in patients with OSCC in comparison with individuals without OSCC, suggesting the importance of detecting HPV/HPV-16 and S. anginosus simultaneously in individuals at risk of developing OSCC

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Section: Discussionmentioning

confidence: 99%

Oropharyngeal Squamous Cell Carcinoma: Human Papilloma Virus Coinfection with Streptococcus anginosus

et al. 2019

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“…anginosus is a pathogenic streptococcus found in the human oral cavity, and gastrointestinal and genital tracts. 62) This bacterium causes serious purulent abscesses in various tissues, and subacute infective endocarditis, 63,64) and it has been linked to gastrointestinal and esophageal cancers. [65][66][67] S. anginosus has high acid tolerance and membrane ATPase activity, similar to S. mutans.…”

Section: Physiological Roles Of Proton Pumping Atpases In Bacteriamentioning

confidence: 99%

Proton Pumping ATPases: Rotational Catalysis, Physiological Roles in Oral Pathogenic Bacteria, and Inhibitors

Sekiya

2022

Biological & Pharmaceutical Bulletin

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Proton pumping ATPases, both F-type and V/A-type ATPases, generate ATP using electrochemical energy or pump protons/sodium ions by hydrolyzing ATP. The enzymatic reaction and proton transport are coupled through subunit rotation, and this unique rotational mechanism (rotational catalysis) has been intensively studied. Single-molecule and thermodynamic analyses have revealed the detailed rotational mechanism, including the catalytically inhibited state and the roles of subunit interactions. In mammals, F-and V-ATPases are involved in ATP synthesis and organelle acidification, respectively. Most bacteria, including anaerobes, have F-and/or A-ATPases in the inner membrane. However, these ATPases are not believed to be essential in anaerobic bacteria since anaerobes generate sufficient ATP without oxidative phosphorylation. Recent studies suggest that F-and A-ATPases perform indispensable functions beyond ATP synthesis in oral pathogenic anaerobes; F-ATPase is involved in acid tolerance in Streptococcus mutans, and A-ATPase mediates nutrient import in Porphyromonas gingivalis. Consistently, inhibitors of oral bacterial F-and A-ATPases, such as phytopolyphenols and bedaquiline, strongly diminish growth and survival. Herein, we discuss rotational catalysis of bacterial F-and A-ATPases, and discuss their physiological roles, focusing on oral bacteria. We also review the effects of ATPase inhibitors on the growth and survival of oral pathogenic bacteria. The features of the catalytic mechanism and unique physiological roles in oral bacteria highlight the potential for proton pumping ATPases to serve as targets for oral antimicrobial agents.

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“…The principle mechanism for daptomycin is suggested to be disruption of undecaprenol phosphate recycling, as the result of its formation of a stable complex among undecaprenol diphosphate-containing entities (of peptidoglycan, WTA, and capsular saccharide biosynthesis) in the presence of the phosphatidylglycerol lipid of the membrane . The complex resistance response of S. aureus to daptomycin involves upregulation of the formation of WTA and the DltA activity and increased peptidoglycan thickness. − A molecular mechanism basis for these alterations is not known. Small molecule inhibition of DltB sensitizes S. aureus to aminoglycosides and cationic antimicrobial peptides and is lethal when combined with an inhibitor of WTA biosynthesis. , The relationship of the d -Ala content of the teichoic acids and β-lactam-resistance has not been well studied.…”

Section: Gram-positive Cell Envelopementioning

confidence: 99%

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

Fisher

Mobashery

2020

Chem. Rev.

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The biological diversity of the unicellular bacteriawhether assessed by shape, food, metabolism, or ecological nichesurely rivals (if not exceeds) that of the multicellular eukaryotes. The relationship between bacteria whose ecological niche is the eukaryote, and the eukaryote, is often symbiosis or stasis. Some bacteria, however, seek advantage in this relationship. One of the most successfulto the disadvantage of the eukaryoteis the small (less than 1 μm diameter) and nearly spherical Staphylococcus aureus bacterium. For decades, successful clinical control of its infection has been accomplished using β-lactam antibiotics such as the penicillins and the cephalosporins. Over these same decades S. aureus has perfected resistance mechanisms against these antibiotics, which are then countered by new generations of β-lactam structure. This review addresses the current breadth of biochemical and microbiological efforts to preserve the future of the β-lactam antibiotics through a better understanding of how S. aureus protects the enzyme targets of the β-lactams, the penicillin-binding proteins. The penicillin-binding proteins are essential enzyme catalysts for the biosynthesis of the cell wall, and understanding how this cell wall is integrated into the protective cell envelope of the bacterium may identify new antibacterials and new adjuvants that preserve the efficacy of the β-lactams.

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Comparative Genome Analysis of the Daptomycin-ResistantStreptococcus anginosusStrain J4206 Associated with Breakthrough Bacteremia

Cited by 9 publications

References 72 publications

Oropharyngeal Squamous Cell Carcinoma: Human Papilloma Virus Coinfection with Streptococcus anginosus

Oropharyngeal Squamous Cell Carcinoma: Human Papilloma Virus Coinfection with Streptococcus anginosus

Proton Pumping ATPases: Rotational Catalysis, Physiological Roles in Oral Pathogenic Bacteria, and Inhibitors

β-Lactams against the Fortress of the Gram-Positive Staphylococcus aureus Bacterium

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