Comparative Genomics and Systems Biology of Malaria Parasites Plasmodium

Cai, Hong; Zhou, Zhan; Gu, Jianying; Wang, Yufeng

doi:10.2174/157489312803900965

Cited by 9 publications

(2 citation statements)

References 199 publications

(166 reference statements)

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“…These include single cell technologies for genome sequencing and transcriptomic analyses, genotyping, and whole genome sequencing from dried blood spot samples. In addition, further comparative genomics [ 177 ] among all Plasmodium species infecting humans as well as those infecting nonhuman primates should identify key pathways in host switching. Genomic analysis of longitudinal samples will allow for the identification of population structure changes associated with changing epidemiology and emerging drug resistance.…”

Section: Technology and Its Application To Malaria Biologymentioning

confidence: 99%

malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication

Wirth¹,

Winzeler²,

Fenton³

et al. 2017

PLoS Med

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Basic science holds enormous power for revealing the biological mechanisms of disease and, in turn, paving the way toward new, effective interventions. Recognizing this power, the 2011 Research Agenda for Malaria Eradication included key priorities in fundamental research that, if attained, could help accelerate progress toward disease elimination and eradication. The Malaria Eradication Research Agenda (malERA) Consultative Panel on Basic Science and Enabling Technologies reviewed the progress, continuing challenges, and major opportunities for future research. The recommendations come from a literature of published and unpublished materials and the deliberations of the malERA Refresh Consultative Panel. These areas span multiple aspects of the Plasmodium life cycle in both the human host and the Anopheles vector and include critical, unanswered questions about parasite transmission, human infection in the liver, asexual-stage biology, and malaria persistence. We believe an integrated approach encompassing human immunology, parasitology, and entomology, and harnessing new and emerging biomedical technologies offers the best path toward addressing these questions and, ultimately, lowering the worldwide burden of malaria.

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Section: Technology and Its Application To Malaria Biologymentioning

confidence: 99%

malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication

Wirth¹,

Winzeler²,

Fenton³

et al. 2017

PLoS Med

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“…Other functional studies have shown a set of genes that are critical for the sexual development and now serve as canonical markers of gametocytogenesis [PF3D7_1302100 (Pfg27), PF3D7_0406200 (Pfs16), PF3D7_0935600 (Pfgig), PF3D7_1216500 (Pfmdv-1), PF3D7_0935400 (Pfgdv)] (Josling and Llinas, 2015). Recent studies have observed a transcription factor pfap2-g (PF3D7_1222600), belonging to the Apetala (Api2) family of transcription factors, as the master regulator of gametocytogenesis (Cai et al , 2012; Sinha et al , 2014). In P. falciparum , the DNA-binding protein PfAP2-G has been shown to have a strong correlation with gametocytogenesis.…”

Section: Introductionmentioning

confidence: 99%

Commit, hide and escape: the story ofPlasmodiumgametocytes

2018

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Malaria is the major cause of mortality and morbidity in tropical countries. The causative agent, Plasmodium sp., has a complex life cycle and is armed with various mechanisms which ensure its continuous transmission. Gametocytes represent the sexual stage of the parasite and are indispensable for the transmission of the parasite from the human host to the mosquito. Despite its vital role in the parasite's success, it is the least understood stage in the parasite's life cycle. The presence of gametocytes in asymptomatic populations and induction of gametocytogenesis by most antimalarial drugs warrants further investigation into its biology. With a renewed focus on malaria elimination and advent of modern technology available to biologists today, the field of gametocyte biology has developed swiftly, providing crucial insights into the molecular mechanisms driving sexual commitment. This review will summarise key current findings in the field of gametocyte biology and address the associated challenges faced in malaria detection, control and elimination.

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