Comparative haemato-immunotoxic impacts of long-term exposure to tartrazine and chlorophyll in rats

Abd‐Elhakim, Yasmina M.; Hashem, Mohamed; El-Metwally, Abeer E.; Anwar, Abeer; Abo‐EL‐Sooud, Khaled; Moustafa, Gihan G.; Ali, Haytham

doi:10.1016/j.intimp.2018.08.002

Cited by 32 publications

(14 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other reports have shown behavioral impairment, psychological deficit and biochemical alterations in organs of laboratory rodents when exposed to artificial food additives or colorants in experimental based study (Albasher et al, 2020). Additionally, continuous exposure to food colorants in experimental rodents reveals reproductive alterations and teratogenicity in newborns, testicular damage, cardiomegaly, kidney and liver damage, immune alteration, gastrointestinal toxicity and also toxic to the hematopoietic system (Boussada et al, 2017;Abd-Elhakim et al, 2018;Neeta, 2018;Marwa et al, 2019).…”

Section: Introductionmentioning

confidence: 95%

“…These dyes are certified as colorants by FDA for its food, drug and cosmetic use but it is also generally used in other chemical industries. Toxicological studies have shown that high dose consumption of these colorants is toxic in rats and mice (Abd-Elhakim et al, 2018;Marwa et al, 2019). Synthetic food dyes or colorants include pigments occurring naturally.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Anxiogenic and memory impairment effect of food color exposure: upregulation of oxido-neuroinflammatory markers and acetyl-cholinestrase activity in the prefrontal cortex and hippocampus

Wopara¹,

Modo

Adebayo³

et al. 2021

Heliyon

View full text Add to dashboard Cite

Erythrosine and tartrazine are one of the synthetic azo dye mostly consumed in food, drugs and other industrial compounds. This study was designed to investigate the adverse effect of combine erythrosine and tartrazine on cognitive and neurobehavioral functions, pro-oxidants, endogenous antioxidants, cholinergic system and proinflammatory cytokines in rats. Erythrosine and tartrazine (2 mg/kg, 6 mg/kg, and 10 mg/kg, b.w., p.o, 50:50) was administered to rats (n ¼ 6) for 6 weeks. Memory and neurobehavioral assessment using Novel object recognition test (NORT) and Elevated plus maze (EPM) and biochemical (pro-oxidants and anti-oxidant enzymes) and pro-inflammatory cytokine measurement from the brain sub regions namely, hippocampus and prefrontal cortex were done at the end of treatment. The results showed (p < 0.05) significant decreased memory and neurobehavioral function, increased acetyl-cholinesterase and pro-oxidants activity (Malonaldehyde level and Nitrite), decreased endogenous antioxidants (Glutathione and Catalase) and increased pro-inflammatory cytokines (Tumor necrosis factor-alpha, TNF-α). We suggested that the mechanism by which this oxidative and neuro-inflammatory damage and cholinergic system alteration occur might be related to the release of metabolite in fission of the azo dyes of the combined erythrosine and tartrazine administration in the animals. However, we concluded on these findings that erythrosine and tartrazine dyes significantly provoke the release of oxido-nitrergic and neuroinflammatory stress markers and also may incite acetyl-cholinesterase activities in different brain regions leading to memory and neurobehavioral impairment.

show abstract

Section: Introductionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Anxiogenic and memory impairment effect of food color exposure: upregulation of oxido-neuroinflammatory markers and acetyl-cholinestrase activity in the prefrontal cortex and hippocampus

Wopara¹,

Modo

Adebayo³

et al. 2021

Heliyon

View full text Add to dashboard Cite

show abstract

“…Some reports confirmed that TAZ exerts no dangerous effect in both human and experimental models (5–8). However, other studies reported that TAZ induces neurotoxic (9,10), immunotoxic (11), reprotoxic (12,13), genotoxic, and mutagenic effects (4), as well as irritability, restlessness, and sleep disturbance (14–16). Recently, researchers’ attention has focused on the potential teratogenic effects of some food additives in pregnant women.…”

Section: Introductionmentioning

confidence: 99%

Embryotoxic and Teratogenic Effects of Tartrazine in Rats

et al. 2019

Self Cite

View full text Add to dashboard Cite

Tartrazine (TAZ) is one of the most commonly used artificial dyes for foods and drugs. We determined the effect of TAZ on fetal development by examining morphological, visceral, and skeletal malformations in rat fetuses following daily oral administration of TAZ to pregnant Wistar rats at the 6th–15th day of gestation. TAZ at 0.45 and 4.5 mg/kg induced 6.0 and 7.1% fetal resorptions, as well as 10.0 and 10.5% fetal mortality, respectively. Fetal body weight and length were significantly lower in the groups treated with TAZ at 0.45 (3.97 ± 0.21 g and 27.3 ± 0.54 mm, respectively) and 4.5 mg/kg (3.48 ± 0.15 g and 23.22 ± 1.02 mm, respectively) than in the control group (4.0 ± 0.15 g and 30.01 ± 0.42 mm, respectively). TAZ at 0.45 and 4.5 mg/kg induced hepatic damage (20 and 33.3%, respectively), dark brown pigmentation due to hemosiderin in the splenic parenchyma (16.7 and 21.7%, respectively), as well as destructed and necrotic renal tubules (16.7 and 26.7%, respectively) in the fetuses. Moreover, TAZ at 0.45 and 4.5 mg/kg caused one or more missing coccygeal vertebrae (20 and 40%, respectively), missing sternebrae (6 and 10%, respectively), missing hind limbs (24 and 4%, respectively), and irregular ribs (16 and 20, respectively) in the fetuses. We concluded that TAZ has embryotoxic and teratogenic potentials in rats.

show abstract

“…A recent report on artificial food colors in grocery products marketed to children in North Carolina (USA) found that tartrazine was present in 20.5% of the products for consumption [4]. Tartrazine is a synthetic azodye used as a food colorant to achieve yellow or green shades in sweets, jellies, juices, jams, mustard, and sodas [5]. Additionally, it has been extensively used to dye human pharmaceuticals, such as vitamin capsules, antacids, and cosmetics [5, 6].…”

Section: Introductionmentioning

confidence: 99%

“…Tartrazine is a synthetic azodye used as a food colorant to achieve yellow or green shades in sweets, jellies, juices, jams, mustard, and sodas [5]. Additionally, it has been extensively used to dye human pharmaceuticals, such as vitamin capsules, antacids, and cosmetics [5, 6]. Pharmaceutical manufacturers and distributors from Canada indicate that approximately 450 products contain tartrazine [7].…”

Section: Introductionmentioning

confidence: 99%

Tartrazine Removal from Aqueous Solution by HDTMA-Br-Modified Colombian Bentonite

Otavo-Loaiza

Sanabria‐González

Giraldo-Gómez

2019

The Scientific World Journal

View full text Add to dashboard Cite

The effect of pH, ionic strength (NaCl added), agitation speed, adsorbent mass, and contact time on the removal of tartrazine from an aqueous solution, using an organobentonite, has been studied. A complete factorial design 32 with two replicates was used to evaluate the influence of the dye concentration (30, 40, and 50 mg/L) and amount of adsorbent (25, 35, and 45 mg) on decolorization of the solution. Experimental data were evaluated with Design Expert® software using a response surface methodology (RSM) in order to obtain the interaction between the processed variables and the response. pH values between 2 and 9, stirring speed above 200 rpm, and contact time of 60 min did not have a significant effect on decolorization. The optimum conditions for maximum removal of tartrazine from an aqueous solution of 30 mg/L were follows: pH = 6.0, NaCl concentration = 0.1 M, stirring speed = 230 rpm, temperature = 20°C, contact time = 60 min, and the organobentonite amount = 38.04 mg. The equilibrium isotherm at 20°C was analyzed by means of the Langmuir and Freundlich models, and the maximum adsorption capacity obtained was 40.79 ± 0.71 mg/g. This adsorption process was applied in a sample of industrial wastewater containing tartrazine and sunset yellow, having obtained a decolorization rate higher than 98% for both dyes. These results suggest that organobentonite is an effective adsorbent for the removal of anionic dyes from an aqueous solution.

show abstract

Comparative haemato-immunotoxic impacts of long-term exposure to tartrazine and chlorophyll in rats

Cited by 32 publications

References 52 publications

Anxiogenic and memory impairment effect of food color exposure: upregulation of oxido-neuroinflammatory markers and acetyl-cholinestrase activity in the prefrontal cortex and hippocampus

Anxiogenic and memory impairment effect of food color exposure: upregulation of oxido-neuroinflammatory markers and acetyl-cholinestrase activity in the prefrontal cortex and hippocampus

Embryotoxic and Teratogenic Effects of Tartrazine in Rats

Tartrazine Removal from Aqueous Solution by HDTMA-Br-Modified Colombian Bentonite

Contact Info

Product

Resources

About