2023
DOI: 10.1186/s13065-023-01025-x
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Comparative HPTLC study for simultaneous determination of ivabradine and metoprolol using UV and fluorescence detectors

M. Rizk,
Shereen Mowaka,
Mariam Mohamed
et al.

Abstract: New, simple, accurate, sensitive and validated high performance thin layer chromatographic (HPTLC) method coupled with UV absorbance mode and fluorescence (FL) detectors which were used for simultaneous determination of ivabradine (IVA) and metoprolol (MET) in their bulk and pharmaceutical dosage form using TLC silica 60 F254 plates and non-fluorescent TLC silica gel 60 plates. The developing system was chloroform: methanol: formic acid: ammonia (8.5:1.5:0.2:0.1, v/v). Desnitometric analysis in UV absorbance m… Show more

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