Comparative immunocytochemical study of FMRFamide neuronal system in the brain of Danio rerio and Acipenser ruthenus during development

Pinelli, Claudia; D’Aniello, Biagio; Sordino, Paolo; Meyer, Dietrich; Fiorentino, Maria; Rastogi, Rakesh K.

doi:10.1016/s0165-3806(99)00172-8

Cited by 40 publications

(69 citation statements)

References 51 publications

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“…This organization was lost in subsequent stages of development; indeed, in juveniles as in the adults, neurons were absent in all areas rostral to the septal area. A similar ontogenetic distribution profile in other vertebrates has been shown with the origin of part of FMRFamide-ir cell bodies from the olfactory placode [Northcutt and Muske, 1994;Yamamoto et al, 1996;Fiorentino et al, 1999;Pinelli et al, 2000]. Nevertheless, in early embryonic stages of the viviparous skink, the olfactory placodes were totally devoid of FMRFamide-ir elements.…”

Section: Ontogenesissupporting

confidence: 70%

“…In contrast, ir perikarya in the suprachiasmatic and infundibular areas were not affected by placodal ablation. Furthermore, in the study on zebrafish it was proposed that hypothalamic FMRFamide neurons originate from the neuroepithelia of the infundibular recess [Pinelli et al, 2000]. The placodal origin of FMRFamide neurons was also confirmed by Yamamoto et al [1996] after placodal transplantation experiments in birds.…”

Section: Introductionmentioning

confidence: 93%

“…In zebrafish embryos FMRFamide-ir cells were observed in the olfactory placode at 30 h after fertilization [Pinelli et al, 2000] when the brain is largely undifferentiated. A similar situation was described in the toad in which the olfactory placode showed the presence of FMRFamideexpressing cells in an early stage of development .…”

Section: Ontogenesismentioning

confidence: 99%

“…Such studies have so far involved birds [Wirsig-Wiechmann, 1990;Yamamoto et al, 1996], amphibians [Northcutt and Muske, 1994;D'Aniello et al, 1996] and fish [Ekstrom et al, 1988;Pinelli et al, 2000]. Some studies provided evidence of the fact that rostral forebrain-located FMRFamide-like-immunoreactive (ir) neurons originate in the olfactory placode and migrate into the brain during the ontogeny.…”

Section: Introductionmentioning

confidence: 99%

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Localization of FMRFamide-Like Immunoreactivity in the Brain of the Viviparous Skink <i>(Chalcides chalcides)</i>

D’Aniello¹,

Fiorentin²,

Pinelli³

et al. 2001

Brain Behav Evol

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Neuroanatomical distribution of FMRFamide-like immunoreactivity was investigated in the brain and olfactory system of the viviparous skink, Chalcides chalcides. In the adult brain FMRFamide immunoreactive (ir) perikarya were observed in the diagonal band of Broca, medial septal nucleus, accumbens nucleus, bed nucleus of the anterior commissure, periventricular hypothalamic nucleus, lateral forebrain bundle, and lateral preoptic, subcommissural, suprachiasmatic and lateral hypothalamic areas. This pattern was seen in both male and female brains. Though all major brain areas showed FMRFamide-ir innervation, the densest ir fiber network was observed in the hypothalamus. During development, ir elements were observed for the first time in embryos at mid-pregnancy. FMRFamide perikarya were located along the ventral surface of the vomeronasal nerve, in the olfactory peduncle mediobasally, as well as in the anterior olfactory nucleus and olfactory tubercle. Furthermore, some ir neurons were observed in the rhombencephalic reticular substance; however, the ir fiber network was poorly developed. Later in development FMRFamide-ir neurons appeared also in the bed nucleus of the anterior commissure as well as the rhombencephalic nucleus of solitary tract and the dorsal motor nucleus of vagus nerve. In juveniles, the distribution profile of FMRFamide immunoreactivity was substantially similar to that of the adults, with a less widespread neuronal distribution and a more developed fiber network. Ontogenetic presence of FMRFamide immunoreactivity in the nasal area has been linked to the presence of a nervus terminalis in this reptile.

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Section: Ontogenesissupporting

confidence: 70%

Section: Introductionmentioning

confidence: 93%

Section: Ontogenesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Localization of FMRFamide-Like Immunoreactivity in the Brain of the Viviparous Skink <i>(Chalcides chalcides)</i>

D’Aniello¹,

Fiorentin²,

Pinelli³

et al. 2001

Brain Behav Evol

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“…Bulbectomy resulted in a strong reduction of FMRFamide immunostaining in the forebrain, midbrain and retina (Fig.·5). This suggests that the TN is the main supplier for FMRFamide in those areas (see also Pinelli et al, 2000). While methionine increased visual sensitivity in control fish, it was not effective in bulbectomized fish ( Fig.·6; Table·1).…”

Section: Bulbectomy Eliminates the Modulation Of Visual Sensitivity Bymentioning

confidence: 89%

Olfactory input increases visual sensitivity in zebrafish: a possible function for the terminal nerve and dopaminergic interplexiform cells

Maaswinkel

2003

Journal of Experimental Biology

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SUMMARY Centrifugal innervation of the neural retina has been documented in many species. In zebrafish Danio rerio, the only so-far described centrifugal pathway originates from terminal nerve (TN) cell bodies that are located in the olfactory bulb. Most of the TN axons terminate in the forebrain and midbrain, but some project via the optic nerve to the neural retina, where they synapse onto dopaminergic interplexiform cells (DA-IPCs). While the anatomical pathway between the olfactory and visual organs has been described, it is unknown if and how olfactory signals influence visual system functions. We demonstrate here that olfactory input is involved in the modulation of visual sensitivity in zebrafish. As determined by a behavioral assay and by electroretinographic (ERG) recording, zebrafish visual sensitivity was increased upon presentation of amino acids as olfactory stimuli. This effect, however, was observed only in the early morning hours when zebrafish are least sensitive to light. The effect of olfactory input on vision was eliminated after lesion of the olfactory bulbs or after the destruction of DA-IPCs. Intraocular injections of a dopamine D2 but not a D1 receptor antagonist blocked the effect of olfactory input on visual sensitivity. Although we cannot exclude the involvement of other anatomical pathways, our data suggest that the TN and DA-IPCs are the prime candidates for olfactory modulation of visual sensitivity.

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Isolation, characterization, and distribution of a novel neuropeptide, Rana RFamide (R‐RFa), in the brain of the European green frog Rana esculenta

Chartrel

Dujardin

Leprince

et al. 2002

J of Comparative Neurology

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A novel neuropeptide of the RFamide peptide family was isolated in pure form from a frog (Rana esculenta) brain extract by using reversed-phase high performance liquid chromatography in combination with a radioimmunoassay for mammalian neuropeptide FF (NPFF). The primary structure of the peptide was established as Ser-Leu-Lys- Pro-Ala-Ala-Asn-Leu-Pro-Leu- Arg-Phe-NH(2). The sequence of this neuropeptide, designated Rana RFamide (R-RFa), exhibits substantial similarities with those of avian LPLRFamide, gonadotropin-inhibitory hormone, and human RFRP-1. The distribution of R-RFa was investigated in the frog central nervous system by using an antiserum directed against bovine NPFF. In the brain, immunoreactive cell bodies were primarily located in the hypothalamus, i.e., the anterior preoptic area, the suprachiasmatic nucleus, and the dorsal and ventral hypothalamic nuclei. The most abundant population of R-RFa-containing neurons was found in the periependymal region of the suprachiasmatic nucleus. R-RFa- containing fibers were widely distributed throughout the brain from the olfactory bulb to the brainstem, and were particularly abundant in the external layer of the median eminence. In the spinal cord, scattered immunoreactive neurons were found in the gray matter. R-RFa-positive processes were found in all regions of the spinal cord, but they were more abundant in the dorsal horn. This study provides the first characterization of a member of the RFamide peptide family in amphibians. The occurrence of this novel neuropeptide in the hypothalamus and median eminence and in the dorsal region of the spinal cord suggests that, in frog, R-RFa may exert neuroendocrine activities and/or may be involved in the transmission of nociceptive stimuli.

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Comparative immunocytochemical study of FMRFamide neuronal system in the brain of Danio rerio and Acipenser ruthenus during development

Cited by 40 publications

References 51 publications

Localization of FMRFamide-Like Immunoreactivity in the Brain of the Viviparous Skink <i>(Chalcides chalcides)</i>

Localization of FMRFamide-Like Immunoreactivity in the Brain of the Viviparous Skink <i>(Chalcides chalcides)</i>

Olfactory input increases visual sensitivity in zebrafish: a possible function for the terminal nerve and dopaminergic interplexiform cells

Isolation, characterization, and distribution of a novel neuropeptide, Rana RFamide (R‐RFa), in the brain of the European green frog Rana esculenta

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