Comparative in vitro antimicrobial activity of chinese medicinal herbs

Franzblau, Scott G.; Cross, Christina J.

doi:10.1016/0378-8741(86)90166-2

Cited by 37 publications

(28 citation statements)

References 10 publications

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“…Previous studies have shown indigo and indirubin to be the main effective components of three species [13][14][15][16][17][18][19], but our research showed large differences in the concentrations of indigo and indirubin among these species. They have similar pharmacological activity, so this may be because of the differences in testing samples.…”

Section: Chemical Composition Analysiscontrasting

confidence: 46%

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Identification of three species commonly known as “daqingye” by internal leaf anatomy and high-performance liquid chromatography analyses

et al. 2018

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The macroscopic and microscopic morphologies and indigo and indirubin concentration of the traditional Chinese medicine herbs Isatis indigotica Fort., Polygonum tinctorium Ait., and Baphicacanthus cusia (Nees) Bremek, all commonly known as "daqingye", were determined and compared. The morphological analyses indicated that I. indigotica has leaves with winged petioles and no glandular hairs or crystals, P. tinctorium has leaves with membranous ocrea and clusters of calcium oxalate, and B. cusia has palisade cells in the mesophyll running over the main vein and single cells containing calcium carbonate crystals. Indigo and indirubin are chemical constituents that have been previously isolated from daqingye and were selected in this study as identification markers for high-performance liquid chromatography analysis due to their pharmacological activities. The chromatographic results showed that indigo and indirubin concentration varied significantly among the three species: high concentration of both indigo and indirubin were observed in I. indigotica, the highest concentration among the three daqingye plants was found in P. tinctorium but with low levels of indirubin, and the concentration of indigo and indirubin was quite low in B. cusia. In summary, three different species commonly known as daqingye were accurately distinguished by morphological observation, internal leaf anatomy analysis, and chromatographic analysis.

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Section: Chemical Composition Analysiscontrasting

confidence: 46%

“…Overall, more than 50 chemical constituents have been identified in daqingye plants, including alkaloids, sucrose, organic acids, and glycosides [16]. Reports have indicated that the useful contents in these plants are indigo, indirubin, tryptanthrin, and kaempferol [17,18].…”

Section: Digital Signaturementioning

confidence: 99%

Identification of three species commonly known as “daqingye” by internal leaf anatomy and high-performance liquid chromatography analyses

et al. 2018

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“…Huanglian (Coptidis rhizoma) is a herb that is widely used in traditional Chinese medicine as an antimicrobial in the treatment of dysentery, gastroenteritis as well as other inflammatory conditions, such as pneumonia and infection of the head and face (5). Recent studies have shown that huanglian extract and its major component, berberine, possess anticancer activities, as indicated by their abilities to inhibit cell growth and induce apoptosis in several different cancer cell lines (6)(7)(8)(9)(10)(11)(12)(13).…”

Section: Introductionmentioning

confidence: 99%

The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-β and TNF-α in human breast cancer cells

Kang

Liu²,

Wang³

et al. 2005

Carcinogenesis

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Huanglian (Coptidis rhizoma), a widely used herb in traditional Chinese medicine, has been shown recently to possess anticancer activities. However, the molecular mechanism underlying the anticancer effect of the herb is poorly understood. Specifically, whether huanglian extract affects the expression of cancer-related genes has not been defined. This study used DNA microarray technology to examine the effect of the herbal extract on expression of the common genes involved in carcinogenesis in two human breast cancer cell lines, the ER-positive MCF-7 and ERnegative MDA-MB-231 cells. Treatment of the cancer cells with huanglian extract markedly inhibited their proliferation in a dose-and time-dependent manner. The growth inhibitory effect was much more profound in MCF-7 cell line than that in MDA-MB-231 cells. DNA microarray assay revealed that treatment with huanglian dramatically increased the mRNA expression of interferon-b (IFN-b) and tumor necrosis factor-a in MCF-7 cells. Quantitative analysis by real-time PCR or western blotting confirmed the upregulation of the two genes (especially IFN-b) in MCF-7 cells, but not in MDA-MB-231 cells. Addition of neutralizing antibody against IFN-b to culture medium markedly inhibited the huanglian-induced antiproliferative effect, confirming the involvement of IFN-b in the huanglian's effect and also suggesting an autocrine pathway for the action of IFN-b in this setting. Given that IFNb is among the most important anticancer cytokines, the upregulation of this gene by huanglian is, at least in part, responsible for its antiproliferative effect. The results of this study implicate huanglian as a promising herb for chemoprevention and chemotherapy of certain cancers.

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“…Eighteen herbs were also evaluated against 10 microbial pathogens. Eleven of the preparations were active against at least one pathogen, six were active against at least three pathogens, and two were active against five pathogens (Franzblau and Cross, 1986).…”

Section: Asian Medicinal Herbsmentioning

confidence: 99%