Comparative Mass Spectrometry–based Proteomics To Elucidate the Acid Stress Response in<i>Lactobacillus Plantarum</i>

Aim: The objective of this study was to identify the genes involved in plantaricin synthesis and adaptive stress response in four Lactobacillus plantarum strains (AS-6, AS-8, AS-9 and AS-10) and one Lactobacillus paraplantarum strain (AS-7) for their usage in medicine and industry. Materials & methods: Whole genomes of these strains were sequenced by a high-throughput sequencing technique known as next-generation sequencing via Ilumina MiSeq platform and the genes were identified by using various bioinformatics tools and software. Results: Plantaricin genes ( plnD, plnE, plnF, plnG, plnI) and genes regulating response to temperature, pH, bile salt, osmotic and oxidative stress were identified in all strains. Conclusion: Lactobacilli could be an option to combat antimicrobial resistance and might replace harmful antibiotics in future.

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Next-Generation Sequencing to Elucidate Adaptive Stress Response and Plantaricin Genes among Lactobacillus Plantarum Strains

Jabbar

Ikram-ul-Haq

Mukhtar

et al. 2020

Future Microbiol.

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Comparative Mass Spectrometry–based Proteomics To Elucidate the Acid Stress Response inLactobacillus Plantarum

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References 30 publications

Next-Generation Sequencing to Elucidate Adaptive Stress Response and Plantaricin Genes among Lactobacillus Plantarum Strains

Next-Generation Sequencing to Elucidate Adaptive Stress Response and Plantaricin Genes among Lactobacillus Plantarum Strains

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