2024
DOI: 10.1101/2024.02.17.580646
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Comparative Multi-omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provides Insights into Type 2 Diabetes Genetics

Eishani Kumar Sokolowski,
Romy Kursawe,
Vijay Selvam
et al.

Abstract: Endoplasmic reticulum (ER) and inflammatory stress responses are two pathophysiologic factors contributing to islet dysfunction and failure in Type 2 Diabetes (T2D). However, how human islet cells respond to these stressors and whether T2D-associated genetic variants modulate these responses is unknown. To fill this knowledge gap, we profiled transcriptional (RNA-seq) and epigenetic (ATAC-seq) remodeling in human islets exposed toex vivoER (thapsigargin) or inflammatory (IL-1β+IFN-γ) stress. 5,427 genes (∼32%)… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 166 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?