Comparative outcomes in electroconvulsive therapy (ECT): A naturalistic comparison between outcomes in psychosis, mania, depression, psychotic depression and catatonia

Tor, Phern‐Chern; Tan, Xiao; Martin, Donel; Loo, Colleen

doi:10.1016/j.euroneuro.2021.04.023

Cited by 29 publications

(12 citation statements)

References 64 publications

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“…Intriguingly, electroconvulsive therapy (ECT) has been identified as a potential intervention to increase hippocampal volume, global functioning, and quality of life in patients [ 86 – 88 ]. We believe these results emphasize the validity of hippocampal GMV as a transdiagnostic correlate of psychopathology that could be a target for intervention and prevention.…”

Section: Discussionmentioning

confidence: 99%

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

et al. 2022

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Major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia spectrum disorder (SSD, schizophrenia, and schizoaffective disorder) overlap in symptomatology, risk factors, genetics, and other biological measures. Based on previous findings, it remains unclear what transdiagnostic regional gray matter volume (GMV) alterations exist across these disorders, and with which factors they are associated. GMV (3-T magnetic resonance imaging) was compared between healthy controls (HC; n = 110), DSM-IV-TR diagnosed MDD (n = 110), BD (n = 110), and SSD patients (n = 110), matched for age and sex. We applied a conjunction analysis to identify shared GMV alterations across the disorders. To identify potential origins of identified GMV clusters, we associated them with early and current risk and protective factors, psychopathology, and neuropsychology, applying multiple regression models. Common to all diagnoses (vs. HC), we identified GMV reductions in the left hippocampus. This cluster was associated with the neuropsychology factor working memory/executive functioning, stressful life events, and with global assessment of functioning. Differential effects between groups were present in the left and right frontal operculae and left insula, with volume variances across groups highly overlapping. Our study is the first with a large, matched, transdiagnostic sample to yield shared GMV alterations in the left hippocampus across major mental disorders. The hippocampus is a major network hub, orchestrating a range of mental functions. Our findings underscore the need for a novel stratification of mental disorders, other than categorical diagnoses.

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Section: Discussionmentioning

confidence: 99%

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

et al. 2022

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“…Guidelines ( Jaffe, 2002 ; National Institute for Clinical Excellence [NICE], 2003 ; Ravindran et al, 2009 ) for specific indications for ECT vary depending on the country; however, ECT efficacy for some diseases seem to be consistently accepted across countries. ECT is generally considered more effective, fast-acting, and safe for patients with major depressive disorder (especially when psychotic symptoms are present or when drug resistance and/or suicidal ideation are present), catatonic symptoms, and major manic episodes ( Tor et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Association between electroconvulsive therapy and depressive disorder from 2012 to 2021: Bibliometric analysis and global trends

Cai

Yang

et al. 2022

Front. Hum. Neurosci.

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BackgroundDepressive disorder is a chronic mental illness that is vulnerable to relapse, imposes a huge economic burden on society and patients, and is a major global public health problem. Depressive disorders are characterized by depressed mood, decreased energy and interest, and suicidal ideation and behavior in severe cases. They can be treated through pharmacotherapy and psychotherapy or physical treatments such as electroconvulsive therapy (ECT). In patients with suicidal ideation, behavior, or refractory depressive disorder ECT has a faster onset of action and better efficacy than pharmacotherapy. This study used bibliometric and visual analyses to map the current state of global research on ECT for depressive disorder and to predict future research trends in this area.Materials and methodsA literature search was performed for studies on ECT and depressive disorder in the Web of Science Core Collection (WoSCC) database. All studies considered for this paper were published between 2012 and 2021. Bibliometric and co-occurrence analyses were performed using the CiteSpace software.ResultsIn total, 2,184 publications were retrieved. The number of publications on ECT and depressive disorder have been increasing since 2012, with China being a emerging hub with a growing influence in the field. Zafiris J. Daskalakis is the top author in terms of number of publications, and The Journal of ECT is not only the most published journal but also the most co-cited journal in the field. Co-occurrence analysis showed that electroconvulsive therapy, treatment-resistant depression, bipolar disorder, hippocampus, efficacy, and electrode placement are current research hotspots. Molecular biomarkers, neuroimaging predictors, and late-life depression will become research hotspots in the future.ConclusionOur analysis made it possible to observe an important growth of the field since 2012, to identify key scientific actors in this growth and to predict hot topics for future research.

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“…Electroconvulsive therapy (ECT) is one of the most effective options for the treatment of pharmacoresistant major depressive disorder (MDD), bipolar disorder that has not responded to other treatments, suicidal behavior, severe agitation, and to manage catatonia and clozapine-resistant schizophrenia ( Tor et al, 2021 ). MDD is one of the most prevalent mental disorders across the world, potentially life-threatening when left untreated.…”

Section: Introductionmentioning

confidence: 99%

A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans

Castro

Bicca

et al. 2023

Front. Hum. Neurosci.

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IntroductionElectroconvulsive therapy (ECT) is one of the most effective strategies for treating resistant major depression. Although the mechanism of action is not fully understood and studies are limited, epigenetics is a promising area for the development of biomarkers associated with ECT treatment response.AimWe reviewed studies available in the literature that explored the epigenetics of ECT in peripheral samples from patients with major depressive disorder (MDD).MethodsA systematic review was performed following The PRISMA guidelines. The search was performed in seven electronic databases: Scopus, Web of Science, Medline, PsycINFO, Embase, Cochrane, and Cinahl.ResultsNine studies were included. Seven assessed DNA methylation and three investigated microRNAs (miR). Overall, most studies were exploratory, with small sample sizes, and we found high heterogeneity between the study’s design, ECT protocols, molecular biology methods, and epigenetic findings. Investigated candidates with some evidence of association with ECT treatment response were BDNF, S100A10, RNF213M, TNKS, FKBP5, miR-126, miR-106a, and miR-24.ConclusionThe present findings seem to support previous preclinical research, suggesting that epigenetic mechanisms play an important role in the molecular mechanism underlying ECT effects.

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Comparative outcomes in electroconvulsive therapy (ECT): A naturalistic comparison between outcomes in psychosis, mania, depression, psychotic depression and catatonia

Cited by 29 publications

References 64 publications

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

Reduced hippocampal gray matter volume is a common feature of patients with major depression, bipolar disorder, and schizophrenia spectrum disorders

Association between electroconvulsive therapy and depressive disorder from 2012 to 2021: Bibliometric analysis and global trends

A systematic mini-review of epigenetic mechanisms associated with electroconvulsive therapy in humans

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