Comparative paraCEST effect of amide and hydroxy groups in divalent cobalt and nickel complexes of tripyridine-based ligands

Panda, Suvam Kumar; Torres, Julia; Kremer, Carlos; Singh, Akhilesh Kumar

doi:10.1039/d3dt01422c

Cited by 4 publications

(3 citation statements)

References 67 publications

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“…Co( ii )-based non-macrocyclic and macrocyclic paraCEST probes have been investigated by many other groups, and similar trends in the CEST intensity with respect to the temperature and pH have also been detected. 19,20,27,32,33,35,36 Therefore, the studied paraCEST results of this current investigation are reliable and comparable with the earlier reported literature (Table 3).…”

Section: Resultssupporting

confidence: 91%

Study of paraCEST response on six-coordinated Co(ii) and Ni(ii) complexes of a pyridine-tetraamide-based ligand

Panda,

Rai,

Singh

2023

Dalton Trans.

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Section: Resultssupporting

confidence: 91%

Study of paraCEST response on six-coordinated Co(ii) and Ni(ii) complexes of a pyridine-tetraamide-based ligand

Panda,

Rai,

Singh

2023

Dalton Trans.

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“…All of the reflection files were generated with the help of Apex-3 software, and SHELXTL software was used to solve and refine the structure. The obtained crystal data were solved according to our previously reported procedures. ,, Crystal data and structure refinement details are provided in Table .…”

Section: Methodsmentioning

confidence: 99%

“…The obtained crystal data were solved according to our previously reported procedures. 52,69,70 Crystal data and structure refinement details are provided in Table 1.…”

Section: Synthesis Of Rc′−gamentioning

confidence: 99%

Robust Optical Detection of Ga³⁺ by a Rhodamine- and Coumarin-Based Proficient Probe: Theoretical Investigations and Biological Applications

Panda,

Sahu,

Goswami

et al. 2023

ACS Appl. Bio Mater.

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The present investigation highlights a rhodamine-Band coumarin-based efficient probe that selectively detects Ga 3+ over other metal ions. The active pocket of the ligand for trapping the metal ions and the binding stoichiometry of its Ga 3+ complex were discovered by single-crystal X-ray diffraction (SC-XRD) analysis. This binding stoichiometry was further confirmed in the solution state by mass spectrometry and Job's plot. The detection limit was found to be at the nanomolar level. Pyrophosphate being a well-known quencher could easily quench the fluorescence intensity of the RC in the presence of Ga 3+ and reversibly recognize Ga 3+ in the solution. The spiro ring opening of the ligand after Ga 3+ insertion is proposed to be the principal mechanism for the turn-on fluorescence response. This ring opening was confirmed by SC-XRD data and nuclear magnetic resonance (NMR) titration experiments. Both ground-and excited-state calculations of the ligand and complex have been carried out to obtain information about their energy levels and to obtain the theoretical electronic spectra. Furthermore, the live-cell imaging of the probe only and the probe after the addition of Ga 3+ have been carried out in HaCaT cells and satisfactory responses were observed. Interestingly, with the help of this probe, Ga 3+ can be tracked inside the intracellular organelle such as lysosomes along with other regions of the cell. The article highlights a rhodamine−coumarin-based probe for the detection of Ga 3+ over other metal ions with a nanomolar level detection limit. Structural characterization of the ligand and its Ga 3+ complex was investigated by SC-XRD. Density functional theory (DFT) and time-dependent DFT (TD-DFT) studies were carried out to explore the excited-state energies and electronic spectra. The application of the probe for the detection of Ga 3+ in live cells has been explored, and positive responses were observed.

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Transition metal Parashift and ParaCEST MRI agents: Current progress and challenges

Slade,

Collingwood,

Rogers

2024

Coordination Chemistry Reviews

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Comparative paraCEST effect of amide and hydroxy groups in divalent cobalt and nickel complexes of tripyridine-based ligands

Abstract: Solution state studies of structurally characterized stable and inert Co(ii) and Ni(ii) complexes of tri-pyridine-containing ligands with alcohol and amide pendant arms show potential ParaCEST Contrast behaviour.

Cited by 4 publications

References 67 publications

Study of paraCEST response on six-coordinated Co(ii) and Ni(ii) complexes of a pyridine-tetraamide-based ligand

Study of paraCEST response on six-coordinated Co(ii) and Ni(ii) complexes of a pyridine-tetraamide-based ligand

Robust Optical Detection of Ga³⁺ by a Rhodamine- and Coumarin-Based Proficient Probe: Theoretical Investigations and Biological Applications

Transition metal Parashift and ParaCEST MRI agents: Current progress and challenges

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Comparative paraCEST effect of amide and hydroxy groups in divalent cobalt and nickel complexes of tripyridine-based ligands

Abstract: Solution state studies of structurally characterized stable and inert Co(ii) and Ni(ii) complexes of tri-pyridine-containing ligands with alcohol and amide pendant arms show potential ParaCEST Contrast behaviour.

Cited by 4 publications

References 67 publications

Study of paraCEST response on six-coordinated Co(ii) and Ni(ii) complexes of a pyridine-tetraamide-based ligand

Study of paraCEST response on six-coordinated Co(ii) and Ni(ii) complexes of a pyridine-tetraamide-based ligand

Robust Optical Detection of Ga3+ by a Rhodamine- and Coumarin-Based Proficient Probe: Theoretical Investigations and Biological Applications

Transition metal Parashift and ParaCEST MRI agents: Current progress and challenges

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Robust Optical Detection of Ga³⁺ by a Rhodamine- and Coumarin-Based Proficient Probe: Theoretical Investigations and Biological Applications