Comparative physicochemical stability and clinical anti‐wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers

Mohammadi, Shima; Shokri, Javad; Ranjkesh, Mohammad Reza; Hamed, Shahabaddin Akbari; Monajjemzadeh, Farnaz

doi:10.1111/jocd.13471

Cited by 9 publications

(7 citation statements)

References 20 publications

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“…Many dermo‐cosmetic products are available on the market and are said to be effective in improving expression wrinkles and/or restructuring the dermal matrix, but to the best of our knowledge, no randomized clinical trials have proven their effectiveness 35‐39 …”

Section: Discussionmentioning

confidence: 99%

Prospective randomized clinical study of a new topical formulation for face wrinkle reduction and dermal regeneration

Araco

Araco²

2021

J of Cosmetic Dermatology

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Background A new topical formulation (TF) based on 3 main lifting components has been developed to reduce superficial facial wrinkles. Objectives Determine the effectiveness of this new TF in reducing superficial face wrinkles and restructuring the dermal matrix. Methods Women, aged 30‐65 y.o. with moderate to severe crow's feet wrinkles were included. Exclusion criteria: men; younger than 30 or older than 65 years old; smokers. Patients received 15 IU of botulinum toxin on crow's feet and 2 creams. Fifty patients (Group 1) applied the TP (Product A) and 50 (Group 2) a placebo (Product B). Assessments were made by digital macro‐photography's, Antera 3D, and a patient satisfaction questionnaire. Results From April to June 2019, 100 women were enrolled in the study and were divided into two homogeneous groups. No major or minor side effects were reported. In group 1, wrinkles, texture, static and dynamic crow's feet wrinkles improved significantly at 3 and 6 months. Patients were very satisfied at 3 months and satisfied at 6 months. In group 2, wrinkles and texture improved significantly at 3 months but did not improve at 6 months. Static and dynamic crow's feet wrinkles improved significantly at 1 and 3 months but did not improve significantly at 6 months. Conclusions Our prospective and randomized study has shown that the new TF is safe and effective in reducing superficial face wrinkles and producing dermal regeneration. It, therefore, prolongs the duration of the botulinum toxin. Further controlled study would be necessary to compare the new TF to neurotoxin treatment, or its action alone.

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Section: Discussionmentioning

confidence: 99%

Prospective randomized clinical study of a new topical formulation for face wrinkle reduction and dermal regeneration

Araco

Araco²

2021

J of Cosmetic Dermatology

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“…The results of the ex vivo permeation study proved significant improvement in drug permeation from optimized microspongeloaded emulgel compared to the marketed formulation. Mohammadi S, et al [27], compared physicochemical stability and clinical anti-wrinkle efficacy of transdermal emulgel preparations of sodium ascorbyl phosphate (SAP) and ascorbic acid (AA) on human volunteers. Formulations containing (AA) and or (SAP) both improved elasticity and wrinkles of the skin.…”

Section: Topical Applicationsmentioning

confidence: 99%

Overview of Emulgel as Emergent Topical Delivery: Recent Applications and Advancement

Amgaonkar¹,

Kochar²,

Chandewar³

et al. 2021

JPRI

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Emulgel is an emerging delivery system with added advantages over other topical delivery systems which is proven to be boon for cosmetics and dermatology. Emulgels are emulsion which is converted to Gel, which will make it a non greasy and enhances patient compliance. The amalgamation of the two systems would be advantages in term of high drug loading capacity and low skin irritation, site specific targeting avoiding first-pass metabolism and increase in bioavailability. Work carried out by researchers proved that, Emulgel/ Nanoemulgel loaded with drugs has been found effective in many topical disorders and it is emerging as potential drug delivery system in area of dermatology. In the present review current research works that carried out on Emulgel and nano emulgels are discussed and also highlighted the recent applications of Emulgel in transdermal as well as dental, ocular, vaginal, and other delivery system.

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“…Currently, the anti-ageing active substances used in cosmetics mainly include retinoids, antioxidants, polypeptides, and other functional additives [ 5 , 6 , 7 ]. It was necessary to highlight that those anti-wrinkle polypeptides have been widely applied in high-end brand skin care products, due to their high safety, significant effects, and low dosage [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Design and Evaluation of Complex Polypeptide-Loaded Dissolving Microneedles for Improving Facial Wrinkles in Different Areas

et al. 2022

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Wrinkles are one of the most intuitive manifestations of skin aging. Complex polypeptide-loaded dissolving microneedles (CP-DMNs) for facial wrinkles in different areas have been developed and evaluated for the first time. In optimizing formulations, we compared the differences in CP-DMNs heights on skin insertion depth and skin repair and healing. Furthermore, systemic safety experiments were carried out to provide a reference for clinical application. On this basis, an 84-day efficacy assessment based on the improvement of facial wrinkles in different areas and a comparison between CP-DMNs vs. placebo was performed on 30 healthy subjects. As a result, DMNs with a height of 300 μm presented sufficient strength to pierce the stratum corneum with minimized skin damage. In addition, CP-DMNs possessed excellent biological safety and skin compatibility for clinical application. Compared with placebo, CP-DMNs exhibited obvious improvements in wrinkles distributed in the corners of eyes, under-eyes, and nasolabial folds. Furthermore, after using CP-DMNs for 84 days, facial wrinkles in five different areas were smoothed. In short, the complex polypeptides showed apparent anti-wrinkle efficacy with the aid of DMNs technology, and CP-DMNs seemed to work better on deeper wrinkles, such as frown lines and nasolabial folds.

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Comparative physicochemical stability and clinical anti‐wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers

Cited by 9 publications

References 20 publications

Prospective randomized clinical study of a new topical formulation for face wrinkle reduction and dermal regeneration

Prospective randomized clinical study of a new topical formulation for face wrinkle reduction and dermal regeneration

Overview of Emulgel as Emergent Topical Delivery: Recent Applications and Advancement

Design and Evaluation of Complex Polypeptide-Loaded Dissolving Microneedles for Improving Facial Wrinkles in Different Areas

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