Comparative ploidy response to experimental hydrogen peroxide exposure in Atlantic salmon (Salmo salar)

Chalmers, Lynn; Vera, Luisa María; Taylor, John F.; Adams, Alexandra; Migaud, Hervé

doi:10.1016/j.fsi.2018.07.017

Cited by 31 publications

(6 citation statements)

References 90 publications

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“…Some studies evidenced similar reaction for the environmental conditions in fish with different ploidy [45]. Triploid and diploid Atlantic salmon have similar physiological stress response including comparable expression of the oxidative stress genes [46].…”

Section: Discussionmentioning

confidence: 99%

Telomere Dynamics in the Diploid and Triploid Rainbow Trout (Oncorhynchus mykiss) Assessed by Q-FISH Analysis

Panasiak

Dobosz

Ocalewicz

2020

Genes

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Changes of telomere length with age were assessed in diploid and triploid rainbow trout (Oncorhynchus mykiss) females in the cross-sectional study using Q-FISH technique. Triploid trout as sterile do not invest an energy in gametogenesis and continue to grow, whereas fertile diploid individuals suffer from declines in growth and survival during sexual maturation. However, triploid and diploid specimens exhibited similar patterns of telomere dynamics. Telomere length in the embryos, larvae and one-year-old juveniles did not change significantly. In the second year after hatching, subadults exhibited substantially shortened telomeres, while significant increase of the telomere length was reported in the three-year-old adults. On the other hand, correlation between telomere length and body size was observed in the triploid, but not in the diploid rainbow trout. Telomere shortening observed in two-year-old subadults may have been associated with the premature period of the fast growth in rainbow trout. Similar pattern of the telomere dynamics reported in the fertile diploids and sterile triploids indicated processes related to reproduction did not affect telomere dynamics in this species. Unexpected increase of the telomere length reported during the third year of life confirmed that in rainbow trout telomeric DNA shortens and lengthens, depending on the developmental stage.

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Section: Discussionmentioning

confidence: 99%

Telomere Dynamics in the Diploid and Triploid Rainbow Trout (Oncorhynchus mykiss) Assessed by Q-FISH Analysis

Panasiak

Dobosz

Ocalewicz

2020

Genes

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“…PAA exposure significantly downregulated the expression of cu/znsod and gr in the gills, a tendency previously reported [ 27 , 44 ]. Cu/znsod catalyses the dismutation of superoxide radicals to H 2 O 2 and O 2 to neutralise oxygen radical-mediated toxicity [ 45 ]. The presence of H 2 O 2 in PAA-based products could partly explain the decreased expression of cu/znsod in the gills since high levels of H 2 O 2 can inhibit SOD activity [ 44 , 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…Interleukins are a subset of cytokine molecules involved in the intercellular regulation of the immune system [ 51 ]. IL-1β is a pro-inflammatory cytokine, responsible for the mediation of the inflammatory response and cell proliferation [ 45 ]. Conversely, il10 is an anti-inflammatory cytokine that inhibits macrophage activation, T-cell proliferation, and the production of pro-inflammatory cytokines [ 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts

Osório¹,

Stiller²,

Reiten³

et al. 2022

BMC Zool

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Background Fish encounter oxidative stress several times during their lifetime, and it has a pervasive influence on their health and welfare. One of the triggers of oxidative stress in fish farming is the use of oxidative disinfectants to improve rearing conditions, especially in production systems employing recirculation technology. Here we report the physiological and morphological adaptive responses of Atlantic salmon (Salmo salar L.) post-smolts to intermittent exposure to a potent oxidative agent peracetic acid (PAA). Fish reared in semi-commercial scale brackish water recirculating aquaculture system (RAS) were exposed to 1 ppm PAA every 3 days over 6 weeks. Mucosal and systemic responses were profiled before exposure, 22 and 45 days during the intermittent PAA administration. Results Oxidative stress was likely triggered as plasma antioxidant capacity increased significantly during the exposure period. Adaptive stress response to the periodic oxidant challenge was likewise demonstrated in the changes in plasma glucose and lactate levels. PAA-induced alterations in the transcription of antioxidants, cytokines, heat shock proteins and mucin genes showed a tissue-specific pattern: downregulation was observed in the gills and olfactory rosette, upregulation occurred in the skin, and no substantial changes in the liver. Further, PAA exposure resulted in histological changes in key mucosal organs (i.e. olfactory rosette, skin and gills); pathological alterations were predominant in the gills where cases of epithelial lifting, hypertrophy and clubbing were prevalent. In addition, intermittent PAA administration resulted in an apparent overproduction of mucus in the nasal mucosa. Lastly, PAA did not dramatically alter the ability of salmon to mount a physiological stress response in the presence of a secondary stressor, though some subtle interference was documented in the kinetics and magnitude of plasma cortisol and glucose response post-stress. Conclusions The present study collectively demonstrated that intermittent oxidant exposure was a mild environmental stressor that salmon could mount strong adaptive responses at systemic and mucosal levels. The results will be valuable in optimising the rearing conditions of post-smolts in RAS, especially in adopting water treatment strategies that do not considerably interfere with fish health and welfare.

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“…Other auxiliary compounds hitherto used were shown to affect fish adversely. Tissue injuries and physiological disturbances occur following exposure to similar concentrations of formalin (Buchmann et al 2004b, Jørgensen & Buchmann 2007, PAA (Straus et al 2018) and H 2 O 2 (Polinski et al 2013, Henriksen et al 2015, Chalmers et al 2018, Jia et al 2021. It was therefore noteworthy that the surfactant SPH6 had a relatively low stimulatory effect on expression of inflammatory genes in rainbow trout, and in some cases it downregulated some genes.…”

Section: Discussionmentioning

confidence: 99%

Inflammatory reactions in rainbow trout fins and gills exposed to biocides

et al. 2021

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Several biocides are widely used in rainbow trout aquaculture against various ectoparasites and ectobionts, but the inflammation induced in treated fish is less well described. Dose-response studies were conducted to elucidate the effects on rainbow trout (gills and fins) induced by a series of biocides including formalin, hydrogen peroxide (H2O2), peracetic acid (PAA) and the surfactant SPH6, which was isolated from the bacterium Pseudomonas H6. The compounds have documented antiparasitic effects, but the specific effects on fish needs further documentation. This study was performed over 24 h, and inflammatory reactions were evaluated in gills and fins. A dose-dependent effect was noted for expression of immune genes encoding for IL-1β, TNFα, IFNγ, IL-10, IL-8, lysozyme, serum amyloid A (SAA), hepcidin, precerebellin and complement factor C3. PAA induced the strongest upregulation of cytokine and acute phase reactant genes followed by H2O2 and formalin. SPH6 showed a lower effect, and in several cases the compound induced downregulation of several genes. Gills showed a stronger response compared to fins. The mucous cell density in fins showed a range of changes which varied by compound. PAA, and to a lesser degree H2O2 and formalin, initially induced mucous cell hyperplasia, whereas SPH6 immediately decreased the number of cells containing mucus.

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Comparative ploidy response to experimental hydrogen peroxide exposure in Atlantic salmon (Salmo salar)

Cited by 31 publications

References 90 publications

Telomere Dynamics in the Diploid and Triploid Rainbow Trout (Oncorhynchus mykiss) Assessed by Q-FISH Analysis

Telomere Dynamics in the Diploid and Triploid Rainbow Trout (Oncorhynchus mykiss) Assessed by Q-FISH Analysis

Intermittent administration of peracetic acid is a mild environmental stressor that elicits mucosal and systemic adaptive responses from Atlantic salmon post-smolts

Inflammatory reactions in rainbow trout fins and gills exposed to biocides

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