“…On the other hand, it is intriguing that associations with immune/inflammatory function or other aspects of host defense against pathogens have been demonstrated for 8 of the top 10 genes (or their very close homologs) identified in the largest GWAS meta-analysis of MDD conducted to date (Table 2). 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140 Many other depression-relevant genes identified in earlier large GWASs (as well as meta-analyses of these studies), including PBRM1 , GNL3 , ATP6V1B2 , SP4 , AK294384 , LY86 , KSP37 , SMG7 , NFKB1 , LOC654346 , LAMC2 , ATG7 , CUGBP1 , NFE2L3 , LOC647167 , VCAN , NLGN1 , BBOX1 , ATF3 , RORA , EIF3F , CDH13 , ITGB1 and GRM8 , have also been linked to immune system and/or host defense functions (see Supplementary Table S1 for additional information/relevant references).…”