Comparative Pulmonary Toxicities and Carcinogenicities of Chronically Inhaled Diesel Exhaust and Carban Black in F344 Rats

Nikula, Kristen J.; Snipes, M.B.; Barr, Edward B.; Griffith, William C.; Henderson, Rogene F.; Mauderly, Joe L.

doi:10.1093/toxsci/25.1.80

Cited by 34 publications

(27 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…222 Smaller nanoparticles are correlated with adverse reactions such as impaired macrophage clearance, inflammation, accumulation of particles, and epithelial cell proliferation, followed by fibrosis, emphysema, and the appearance of tumors. 37,40,222,[227][228][229] Particle uptake and potential health effects may be dependent on genetic susceptibility and health status. 212 Recent research has demonstrated that nanoparticle inhalation can affect the immune system defense ability to combat infections.…”

Section: Adverse Health Effects In the Respiratory Tractmentioning

confidence: 99%

Nanomaterials and nanoparticles: Sources and toxicity

2007

View full text Add to dashboard Cite

This review is presented as a common foundation for scientists interested in nanoparticles, their origin, activity, and biological toxicity. It is written with the goal of rationalizing and informing public health concerns related to this sometimes-strange new science of 'nano', while raising awareness of nanomaterials' toxicity among scientists and manufacturers handling them. We show that humans have always been exposed to tiny particles via dust storms, volcanic ash, and other natural processes, and that our bodily systems are well adapted to protect us from these potentially harmful intruders. The reticuloendothelial system in particular actively neutralizes and eliminates foreign matter in the body, including viruses and non-biological particles. Particles originating from human activities have existed for millennia, e.g. smoke from combustion and lint from garments, but the recent development of industry and combustion-based engine transportation has profoundly increased anthropogenic particulate pollution. Significantly, technological advancement has also changed the character of particulate pollution, increasing the proportion of nanometer-sized particles -"nanoparticles" and expanding the variety of chemical compositions. Recent epidemiological studies have shown a strong correlation between particulate air pollution levels, respiratory and cardiovascular diseases, various cancers, and mortality. Adverse effects of nanoparticles on human health depend on individual factors such as genetics and existing disease, as well as exposure, and nanoparticle chemistry, size, shape, agglomeration state, and electromagnetic properties. Animal and human studies show that inhaled nanoparticles are less efficiently removed than larger particles by the macrophage clearance mechanisms in the lung, causing lung damage, and that nanoparticles can translocate through the circulatory, lymphatic, and nervous systems to many tissues and organs, including the brain. The key to understanding the toxicity of nanoparticles is that their minute size, smaller than cells and cellular organelles, allows them to penetrate these basic biological structures, disrupting their normal function. Examples of toxic effects include tissue inflammation, and altered cellular redox balance toward oxidation, causing abnormal function or cell death. The manipulation of matter at the scale of atoms, "nanotechnology", is creating many new materials with characteristics not always easily predicted from current knowledge. Within the near-limitless diversity of these materials, some happen to be toxic to biological systems, others are relatively benign, while others confer health benefits. Some of these materials have desirable characteristics for industrial applications, as nanostructured materials often exhibit beneficial properties, from UV absorbance in sunscreen to oil-less lubrication of motors. A rational science-based approach is needed to minimize harm caused by these materials, while supporting continued study and appropriate industrial develop...

show abstract

Section: Adverse Health Effects In the Respiratory Tractmentioning

confidence: 99%

Nanomaterials and nanoparticles: Sources and toxicity

2007

View full text Add to dashboard Cite

show abstract

“…Currently, the risk‐assessment process for particles is complicated by several other factors. Animal carcinogenicity studies with PSP such as CB, TiO 2 and coal mine dust, which were previously considered inert or “nuisance” dusts, show positive outcomes in rat models 6, 7, 8. In addition, among the PSP, uF particles or nanoparticles, usually defined as being <100 nm in diameter, have been identified as a special group.…”

Section: Particles Relevant For Occupational And/or Ambient Exposurementioning

confidence: 99%

Elective sirolimus‐eluting stent implantation for left main coronary artery disease: Six‐month angiographic follow‐up and 1‐year clinical outcome

Arampatzis

Lemos

Hoye

et al. 2004

Cathet Cardio Intervent

View full text Add to dashboard Cite

The effectiveness of sirolimus-eluting stent (SES) implantation in patients treated electively for left main (LM) stenoses has not been yet ascertained. The present study reports on the clinical and angiographic outcome of 16 consecutive patients treated electively for de novo stenoses in the LM. The impact of SES implantation on major adverse cardiac events was evaluated. Mean age was 65 +/- 11 years. Unprotected LM was present in nine (56%), and eight patients (50%) received stents extending into both the left anterior descending and circumflex arteries for stenoses of the distal left main bifurcation. In-house mortality and reintervention rate was zero. One patient developed a non-Q-wave myocardial infarction related to the index procedure. At 1-year clinical follow-up, there were no deaths or further myocardial infarctions; one (6%) patient required target lesion revascularization. A total of 12 patients (75%) underwent 6-month angiographic follow-up with a late lumen loss of 0.04 +/- 0.65 mm and one focal restenosis (8% of patients). Elective SES implantation for LM disease was associated with zero mortality and a very low incidence of additional major adverse events at 1 year.

show abstract

“…For example, lamp black particles have mean diameters <100 nm while furnace black particles have mean diameters of ~15 nm. [14][15][16] Catalytic decomposition of acetylene (C 2 H 2 ) and methane (CH 4 ) in the presence of a metal catalyst has been a common industrial methodology for carbon nanotube production, 17 This study is an assessment of the contribution of various combustion gas sources to both the indoor and outdoor air, and an evaluation of the pervasiveness of carbon nanotube and related carbon nanoforms in the atmospheric environment. This assessment involves the systematic collection (by thermal precipitation) and analysis of atmospheric nanoparticulates by transmission electron microscopy (TEM).…”

Section: Experimental Methodsmentioning

confidence: 99%