Comparative Qualitative and Quantitative Phytochemical Analysis of Calotropis Gigantea and Calotropis Procera Roots

Mishra, Pratibha; Yadav, Khushwant S.; Shrivastava, Purnima

doi:10.22270/jddt.v8i4.1757

Cited by 2 publications

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“…Qualitative phytochemical analysis of ethyl acetate fraction of G. mangostana L rind was done according to the reported method. It contains several phytochemicals: tannins, terpenoids, triterpenoids, and flavonoids [13], [14].…”

Section: Discussionmentioning

confidence: 99%

Ethyl acetate Fraction of Garcinia Mangostana L Rind Study as Antimalaria and Antioxidant in Plasmodium berghei Inoculated Mice

Tjahjani¹,

Biantoro²,

Tjokropranoto³

2019

Open Access Maced J Med Sci

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BACKGROUND: Drug resistance to malaria is still a problem in various regions, and there have even been developments in resistance to the ACTs (artemisinin-based combination therapies) as standard antimalarial drugs included to artemisinin’s partner drugs. Ethyl acetate fraction of G. mangostana L rind, containing xanthones as an antioxidant, has antimalarial activity in vitro which has a synergistic effect with artemisinin. That’s why the activities of this fraction are needed to be studied in vivo. AIM: To explore the antimalarial and antioxidant activity of ethyl acetate fraction of Garcinia mangostana L rind in mice. METHODS: This was a complete randomised design true experimental study. Six groups of mice: a healthy mice group and 5 groups of Plasmodium berghei inoculated mice treated with various doses of the sample for 3 days compared to artemisinin. Parasitemia and total antioxidant status were examined and analysed using ANOVA, and probit analysis were done.RESULTS: The parasitemia level in all of the treatment groups were lower than the positive control group without treatment (p < 0.01) and the parasitemia level was the lowest in artemisinin group which was not significantly different from the 100 mg/kg body weight dose group (p > 0.05). The parasitemia level in 20 and 4 mg/kg body weight dose groups were higher than the artemisinin group (p < 0.01). Parasite growth inhibition rate from the highest to the lowest consecutively was: artemisinin, 100 mg/kg body weight, 20 mg/kg body weight, 4 mg/kg body weight, and positive control group (p < 0.05) and ED50 was 3.396 mg/kg body weight. Total antioxidant status was the highest in 20 mg/ kg body weight dose and higher than the negative control group (p < 0.05) while the lowest total antioxidant status was in the positive control group. CONCLUSION: Ethyl acetate fraction of G. mangostana L rind potentially showed antimalarial and antioxidant activity in vivo. Further study is needed to explore the detail of its mechanism of action and its quantitative phytochemical analysis to find the leading compound in it.

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Section: Discussionmentioning

confidence: 99%

Ethyl acetate Fraction of Garcinia Mangostana L Rind Study as Antimalaria and Antioxidant in Plasmodium berghei Inoculated Mice

Tjahjani¹,

Biantoro²,

Tjokropranoto³

2019

Open Access Maced J Med Sci

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Preliminary Phytochemical screening and Antioxidant properties of Methanolic root extract of Picrorhiza kurroa

Packirisamy,

Gunam,

Mahendra

et al. 2023

RJPT

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Objective: Picrorhiza kurroa Royle ex Benth. (Scrophulariacae) is a herb in the Ayurvedic system of medicine highly noted for its hepatoprotective effect. Over exploitation for various medicinal purposes has made the rhizome as an endangered species. In spite of its geographical distribution, it is available in all the herbal drug stores. The rationale behind this study is to authenticate and standardize the Picrosides by different parameters to enable its identity, purity and efficacy. Thus, the Present study analyzed the presence of phytochemicals qualitatively and evaluated the antioxidant properties in the methanolic extracts of Picrorhiza kurroa. Methods: Preliminary analysis of phytoconstituents of root parts of this plant using the standard procedures and Antioxidant properties were determined by 1,1- diphenyl,2-picrylhydrazyl (DPPH) assay. Results: The qualitative phytochemical analysis revealed the presence of secondary active constituent’s such as glycosides, cardiacglycosides, Tannins, terpenoids, steroids and coumarins and also possesses high free radical scavenging property. Conclusion: Therefore this study explored the antioxidant properties which strongly supports that could prevent many free radical related disorders. Also paves the way for further quantitative and animal studies, planned to explore the molecular mechanisms for the study based on cardiovascular disorders.

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Comparative Qualitative and Quantitative Phytochemical Analysis of Calotropis Gigantea and Calotropis Procera Roots

Cited by 2 publications

References 1 publication

Ethyl acetate Fraction of Garcinia Mangostana L Rind Study as Antimalaria and Antioxidant in Plasmodium berghei Inoculated Mice

Ethyl acetate Fraction of Garcinia Mangostana L Rind Study as Antimalaria and Antioxidant in Plasmodium berghei Inoculated Mice

Preliminary Phytochemical screening and Antioxidant properties of Methanolic root extract of Picrorhiza kurroa

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