Comparative Quantitative Proteomic Analysis of Melanoma Subtypes, Nevus-Associated Melanoma, and Corresponding Nevi

Naimy, Soraya; Sølberg, Julie B.K.; Kuczek, Dorota E.; Løvendorf, Marianne Bengtson; Bzorek, Michael; Litman, Thomas; Mund, Andreas; Rahbek Gjerdrum, Lise Mette; Clark, Rachael A.; Mann, Matthias; Dyring-Andersen, Beatrice

doi:10.1016/j.jid.2023.12.011

Journal of Investigative Dermatology

2024

DOI: 10.1016/j.jid.2023.12.011

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Comparative Quantitative Proteomic Analysis of Melanoma Subtypes, Nevus-Associated Melanoma, and Corresponding Nevi

Soraya Naimy,

Julie B.K. Sølberg,

Dorota E. Kuczek

et al.

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The 2024 Report on the Human Proteome from the HUPO Human Proteome Project

Omenn,

Orchard,

Lane

et al. 2024

J. Proteome Res.

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The Human Proteome Project (HPP), the flagship initiative of the Human Proteome Organization (HUPO), has pursued two goals: (1) to credibly identify at least one isoform of every proteincoding gene and (2) to make proteomics an integral part of multiomics studies of human health and disease. The past year has seen major transitions for the HPP. neXtProt was retired as the official HPP knowledge base, UniProtKB became the reference proteome knowledge base, and Ensembl-GENCODE provides the reference protein target list. A function evidence FE1−5 scoring system has been developed for functional annotation of proteins, parallel to the PE1−5 UniProtKB/ neXtProt scheme for evidence of protein expression. This report includes updates from neXtProt (version 2023−09) and UniProtKB release 2024_04, with protein expression detected (PE1) for 18138 of the 19411 GENCODE protein-coding genes (93%). The number of non-PE1 proteins ("missing proteins") is now 1273. The transition to GENCODE is a net reduction of 367 proteins (19,411 PE1−5 instead of 19,778 PE1−4 last year in neXtProt). We include reports from the Biology and Disease-driven HPP, the Human Protein Atlas, and the HPP Grand Challenge Project. We expect the new Functional Evidence FE1−5 scheme to energize the Grand Challenge Project for functional annotation of human proteins throughout the global proteomics community, including π-HuB in China.

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The 2024 Report on the Human Proteome from the HUPO Human Proteome Project

Omenn,

Orchard,

Lane

et al. 2024

J. Proteome Res.

View full text Add to dashboard Cite

show abstract

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Comparative Quantitative Proteomic Analysis of Melanoma Subtypes, Nevus-Associated Melanoma, and Corresponding Nevi

Cited by 1 publication

References 78 publications

The 2024 Report on the Human Proteome from the HUPO Human Proteome Project

The 2024 Report on the Human Proteome from the HUPO Human Proteome Project

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