Comparative Solubilities in Water, in Pyridine and in Aqueous Pyridine.

Dehn, William M.

doi:10.1021/ja02252a012

Cited by 37 publications

(9 citation statements)

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“…Dehn [37] reports that 108 g of maltose is soluble in 100 g of H 2 O(l) (T = 293.15 K to 298.15 K). We calculate m(sat) = 3.16 mol Á kg À1 from this result.…”

Section: Comparisons With Results In the Literature And Thermodynamicmentioning

confidence: 99%

Thermodynamics of the hydrolysis reactions of 1,4-β-d-xylobiose, 1,4-β-d-xylotriose, d-cellobiose, and d-maltose

Tewari¹,

Lang²,

Decker³

et al. 2008

The Journal of Chemical Thermodynamics

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“…Dehn [37] reports that 108 g of maltose is soluble in 100 g of H 2 O(l) (T = 293.15 K to 298.15 K). We calculate m(sat) = 3.16 mol Á kg À1 from this result.…”

Section: Comparisons With Results In the Literature And Thermodynamicmentioning

confidence: 99%

Thermodynamics of the hydrolysis reactions of 1,4-β-d-xylobiose, 1,4-β-d-xylotriose, d-cellobiose, and d-maltose

Tewari¹,

Lang²,

Decker³

et al. 2008

The Journal of Chemical Thermodynamics

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“…This could be through effects on the stiffness of the chains, changes in hydrophobicity or charge. In particular, the hydrophobic character of fluorescein and coumarin and their difference in this, as indicated by their aqueous solubility (0.01 M for coumarin, 45 1.5 × 10 −4 M for fluorescein 46 ), or the decrease in solution critical temperature of poly(N-isopropylacrylamide) hydrogels upon integration in these, 47 suggests that their hydrophobicity has a possible effect on the partitioning (e.g., differences in K i,hphob in eq 3).…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Toehold Length of Target ssDNA Affects Its Reaction-Diffusion Behavior in DNA-Responsive DNA-co-Acrylamide Hydrogels

2019

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In the present study, we expand on the understanding of hydrogels with embedded deoxyribonucleic acid (DNA) cross-links, from the overall swelling to characterization of processes that precede the swelling. The hydrogels respond to target DNA strands because of a toehold-mediated strand displacement reaction in which the target strand binds to and opens the dsDNA cross-link. The spatiotemporal evolution of the diffusing target ssDNA was determined using confocal laser scanning microscopy (CLSM). The concentration profiles revealed diverse partitioning of the target DNA inside the hydrogel as compared with the immersing solution: excluding a nonbinding DNA, while accumulating a binding target. The data show that a longer toehold results in faster cross-link opening but reduced diffusion of the target, thus resulting in only a moderate increase in the overall swelling rate. The parameters obtained by fitting the data using a reaction-diffusion model were discussed in view of the molecular parameters of the target ssDNA and hydrogels.

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“…The dissolution kinetics of three materials having poor aqueous solubility were studied: fluorescein in deionized water 44 , ibuprofen in aqueous hydrochloride (HCl) buffer (pH = 1.2) solution 45 , and tamoxifen in aqueous acetate buffer solution 46 (pH = 4.9). (Caffeine exhibited instantaneous dissolution in film form, making it impractical to measure its dissolution kinetics in the film form.…”

Section: Resultsmentioning

confidence: 99%

Printing of small molecular medicines from the vapor phase

et al. 2017

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There is growing need to develop efficient methods for early-stage drug discovery, continuous manufacturing of drug delivery vehicles, and ultra-precise dosing of high potency drugs. Here we demonstrate the use of solvent-free organic vapor jet printing to deposit nanostructured films of small molecular pharmaceutical ingredients, including caffeine, paracetamol, ibuprofen, tamoxifen, BAY 11-7082 and fluorescein, with accuracy on the scale of micrograms per square centimeter, onto glass, Tegaderm, Listerine tabs, and stainless steel microneedles. The printed films exhibit similar crystallographic order and chemistry as the original powders; controlled, order-of-magnitude enhancements of dissolution rate are observed relative to powder-form particles. In vitro treatment of breast and ovarian cancer cell cultures in aqueous media by tamoxifen and BAY 11-7082 films shows similar behavior to drugs pre-dissolved in dimethyl sulfoxide. The demonstrated precise printing of medicines as films, without the use of solvents, can accelerate drug screening and enable continuous manufacturing, while enhancing dosage accuracy.

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Comparative Solubilities in Water, in Pyridine and in Aqueous Pyridine.

Abstract: In determining by the colorimetric method the solubilities of helianthine in water, in pyridine and in aqueous mixtures of the two, the following values were obtained : ,Solvent.

Cited by 37 publications

References 0 publications

Thermodynamics of the hydrolysis reactions of 1,4-β-d-xylobiose, 1,4-β-d-xylotriose, d-cellobiose, and d-maltose

Thermodynamics of the hydrolysis reactions of 1,4-β-d-xylobiose, 1,4-β-d-xylotriose, d-cellobiose, and d-maltose

Toehold Length of Target ssDNA Affects Its Reaction-Diffusion Behavior in DNA-Responsive DNA-co-Acrylamide Hydrogels

Printing of small molecular medicines from the vapor phase

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