Comparative studies of coordination properties of puromycin and puromycin aminonucleoside towards copper(II) ions

Mucha, Ariel; Bal, Wojciech; Jeżowska‐Bojczuk, Małgorzata

doi:10.1016/j.jinorgbio.2007.06.031

Cited by 2 publications

(1 citation statement)

References 44 publications

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“…Initially, LogP values were obtained for certain (fluoro)-quinolones and fluoro-naphthyridines (Ross and Riley, 1992;Takács-Novák et al, 1992;Hansch et al, 1995;Zhidong et al, 2006;Avdeef and Tam, 2010), β-lactams and cyclins (Sangster, 1993;Hansch et al, 1995;Al Bakain et al, 2011), macrolides (McFarland et al, 1997Grabowski et al, 2010), aminoglycosides, and dyes (Hansch et al, 1995;Sarmah et al, 2006;Sanderson and Thomsen, 2009;Grabowski et al, 2010). Subsequently, using a similar method, pK a values were obtained for certain (fluoro)-quinolones and fluoro-naphthyridines (Budavari et al, 1996;Torniainien et al, 1996;Park et al, 2000;Tolls, 2001;Hopfinger et al, 2009;Singh et al, 2009;Avdeef and Tam, 2010;Fujita et al, 2011), β-lactams (Sangster, 1993;Budavari et al, 1996;Khan and Ongerth, 2004;Huang and Hsieh, 2008;Fujita et al, 2011), cyclins (Serjeant and Dempsey, 1979;Avdeef and Tam, 2010;Fujita et al, 2011), macrolides (Budavari et al, 1996;McFarland et al, 1997;Qiang and Adams, 2004) and aminoglycosides (Budavari et al, 1996;Sarmah et al, 2006;Mucha et al, 2008;Fujita et al, 2011).…”

Section: Review Approachmentioning

confidence: 99%

Molecular determinant deciphering of MIC-guided RND efflux substrates in E. coli

Revol-Tissot,

Boyer,

Alibert

2024

Front. Drug Discov.

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Antimicrobial resistance poses an urgent and formidable global public health threat. The escalation of bacterial multidrug resistance to antibiotics has the potential to become a leading cause of global mortality if there is no substantial improvement in antimicrobial development and therapy protocols. In light of this, it is imperative to identify the molecular determinants responsible for the reduced antibiotic activity associated with RND efflux pumps. This comprehensive study meticulously examines Minimum Inhibitory Concentration (MIC) data obtained from in vitro tests for various antibiotic families and non-active dye compounds, sourced from diverse literature references. The primary focus of this study is to assess the susceptibility of these agents to efflux-resistant Escherichia coli strains, integrating both MIC data and relevant physicochemical properties. The central objective is to unveil the specific substituents that significantly influence the uptake process mediated by the AcrAB-TolC efflux system. This exploration seeks to reveal the consequences of these substituents on pharmacodynamic responses, providing valuable insights into Structure-Activity Relationships. It is noteworthy that this analysis represents a pioneering effort, with prospective implications for RND efflux pump-producing strains. Ultimately, deciphering efflux markers is crucial to effectively mitigate the emergence of specific resistance and to better monitor the role of this primary resistance mechanism in Gram-negative bacteria, particularly as observed in clinical antibiotic therapy practice.

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Section: Review Approachmentioning

confidence: 99%

Molecular determinant deciphering of MIC-guided RND efflux substrates in E. coli

Revol-Tissot,

Boyer,

Alibert

2024

Front. Drug Discov.

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Problems with molecular mechanics implementations on the example of 4-benzoyl-1-(4-methyl-imidazol-5-yl)-carbonylthiosemicarbazide

2011

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Results from force fields implemented in HyperChem, a program frequently used in studies of bioactive compounds, have been compared using the example of the conformational analysis of a 1-carbonylthiosemicarbazide that exhibits strong antibacterial activity. By comparing these results with the original force fields and the experimental NMR ROESY spectrum, it was shown that these implementations can lead to erroneous results.

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Comparative studies of coordination properties of puromycin and puromycin aminonucleoside towards copper(II) ions

Cited by 2 publications

References 44 publications

Molecular determinant deciphering of MIC-guided RND efflux substrates in E. coli

Molecular determinant deciphering of MIC-guided RND efflux substrates in E. coli

Problems with molecular mechanics implementations on the example of 4-benzoyl-1-(4-methyl-imidazol-5-yl)-carbonylthiosemicarbazide

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