Comparative Studies of Multiple-Dose Cefoxitin vs. Single-Dose Cefonicid for Surgical Prophylaxis in Patients Undergoing Biliary Tract Operations or Hysterectomy

Maki, Dennis G.; Lammers, Jan L.; Aughey, David

doi:10.1093/clinids/6.supplement_4.s887

Cited by 31 publications

(5 citation statements)

References 20 publications

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“…The experience gained from this study and from others [11][12][13][14][15][16] clearly indicates that the monodose produces at least the same preventive effect as the multidose. It even becomes clear that with the monodose, there is a less pronounced ten…”

Section: Selection and Classification Of Patientssupporting

confidence: 52%

Antimicrobial Prophylaxis in Urologic Surgery: Does It Give Some Benefit?

Rió¹,

Dalet²,

Chéchile³

1993

Eur Urol

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Section: Selection and Classification Of Patientssupporting

confidence: 52%

Antimicrobial Prophylaxis in Urologic Surgery: Does It Give Some Benefit?

Rió¹,

Dalet²,

Chéchile³

1993

Eur Urol

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“…The effect of duration of prophylaxis on outcome has been evaluated. A single dose of a cephalosporin was compared with multiple doses in several studies; no significant differences in efficacy were found [327,329,330,348,349,353,359]. The largest study compared one dose of cefuroxime with three doses in 1,004 patients with risk factors for infection who were undergoing biliary tract surgery [327].…”

Section: Surgical Prophylaxis Guidelinesmentioning

confidence: 99%

Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery

Bratzler

Dellinger

Olsen

et al. 2013

Surgical Infections

1,203

1,225

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T hese guidelines were developed jointly by the American Society of Health-System Pharmacists (ASHP), the Infectious Diseases Society of America (IDSA), the Surgical Infection Society (SIS), and the Society for Healthcare Epidemiology of America (SHEA). This work represents an update to the previously published ASHP Therapeutic Guidelines on Antimicrobial Prophylaxis in Surgery [1], as well as guidelines from IDSA and SIS [2,3]. The guidelines are intended to provide practitioners with a standardized approach to the rational, safe, and effective use of antimicrobial agents for the prevention of surgical site infections (SSIs) based on currently available clinical evidence and emerging issues. Prophylaxis refers to the prevention of an infection and can be characterized as primary prophylaxis, secondary prophylaxis, or eradication. Primary prophylaxis refers to the prevention of an initial infection. Secondary prophylaxis refers to the prevention of recurrence or reactivation of a preexisting infection. Eradication refers to the elimination of a colonized organism to prevent the development of an infection. These guidelines focus on primary perioperative prophylaxis. Guidelines development and use Members of ASHP, IDSA, SIS, and SHEA were appointed to serve on an expert panel established to ensure the validity, reliability, and utility of the revised guidelines. The work of the panel was facilitated by faculty of the

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“…Furthermore, its bactericidal levels are maintained for as long as 24 h after intravenous administration [13]. Sever al studies have demonstrated the efficacy of cefonicid for vaginal hysterectomy prophylaxis [14,15]. However, data on its use in abdominal hysterectomy are meager.…”

Section: Discussionmentioning

confidence: 99%

“…However, data on its use in abdominal hysterectomy are meager. Maki et al [14], who have studied 37 patients receiving cefonicid for TAH prophylaxis, have found it to be superior to cefoxitin. To our best knowledge, no studies comparing cefazolin standard three dose regimen to cefonicid single dose regimen in abdominal hysterectomy are available.…”

Section: Discussionmentioning

confidence: 99%

Comparison of Cefonicid and Cefazolin Prophylaxis in Abdominal Hysterectomy

Tanos

Rojansky²,

Anteby³

1994

Gynecol Obstet Invest

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One hundred and sixty-four patients undergoing abdominal hysterectomy for benign diseases were prospectively evaluated. The efficacy and safety of surgical prophylaxis with a single dose of the long-acting cefonicid was compared to the standard three dose regimen of cefazolin. Prophylaxis was successful in 82 of 85 (96.5%) patients receiving cefonicid and in 77 of 79 (97.5%) patients receiving cefazolin. No serious adverse effects were encountered with both drugs. It is concluded that single dose intravenous cefonicid, when given pre-operatively, is as safe and effective as the standard multiple dose regimen of cefazolin in patients undergoing elective abdominal hysterectomy.

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Comparative Studies of Multiple-Dose Cefoxitin vs. Single-Dose Cefonicid for Surgical Prophylaxis in Patients Undergoing Biliary Tract Operations or Hysterectomy

Cited by 31 publications

References 20 publications

Antimicrobial Prophylaxis in Urologic Surgery: Does It Give Some Benefit?

Antimicrobial Prophylaxis in Urologic Surgery: Does It Give Some Benefit?

Clinical Practice Guidelines for Antimicrobial Prophylaxis in Surgery

Comparison of Cefonicid and Cefazolin Prophylaxis in Abdominal Hysterectomy

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