Comparative Studies of New Complexes Synthesized by Chemical and Tribochemical Reactions Derived from Malonic Acid Dihydrazide (L; MAD) with Cu&amp;lt;sup&amp;gt;2+&amp;lt;/sup&amp;gt; and Co&amp;lt;sup&amp;gt;2+&amp;lt;/sup&amp;gt; Salts

Al-Ashqar, Sawsan M.

doi:10.4236/ojic.2018.81003

OJIC

2018

DOI: 10.4236/ojic.2018.81003

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Comparative Studies of New Complexes Synthesized by Chemical and Tribochemical Reactions Derived from Malonic Acid Dihydrazide (L; MAD) with Cu<sup>2+</sup> and Co<sup>2+</sup> Salts

Sawsan M. Al-Ashqar¹

Abstract: The reaction of L (MAD) The IR spectra of the complexes suggest that L acts in a bidentate manner. Moreover, the results of electronic spectra and magnetic measurements for the chloride and iodide complexes suggest distorted-octahedral and/or tetrahedral for Cu 2+ and high-spin octahedral and/or tetrahedral structures around the Co 2+ ion, respectively.

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2023

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Design, Synthesis and Spectroscopic Characterizations of Medicinal Hydrazide Derivatives and Metal Complexes of Malonic Ester

Parveen

Naseem

Shah

et al. 2023

CBC

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Background: A new series of malonic acid-based hydrazide derivatives (BPMPDH, 2HPMPDH, 3HPMPDH, 4HPMPDH, DMPDH) are successfully synthesized by the reaction of malonic ester hydrazide with various substituted aldehydes like salicylaldehyde, benzaldehyde, 4-hydroxy benzaldehyde, 3-hydroxy benzaldehyde and formaldehyde) Methods: metal complexes of prepared hydrazide derivatives were prepared using metals like Cu+2, Zn+2 and Ni+2 via a mild, efficient and convenient method. Newly synthesized compounds were characterized by IR, NMR (1H & 13C), UV/VIS and mass spectrometry. The presence of –C=N- peak at 1600-1700 cm-1 with the absence of NH2 peak at 3500 cm-1 in FTIR spectra. In 1HNMR peak at, 11.00-13.00 ppm for –OH protons and 7.00-9.50 ppm for –NH verified the synthesis of new hydrazide derivatives. The presence of a C-OH sharp peak at 180-190 ppm, a C=O peak at 160-170 ppm and a C=N peak at 140-150 ppm confirmed synthesis. In mass spectra, the molecular ion peaks at 308 m/z, 340 m/z and 156 m/z confirmed synthesis. Synthesized compounds have also been analyzed for their antioxidant, antibacterial, antifungal, chymotrypsin and tyrosinase inhibition activities Result and Conclusion: The results revealed that the 2HPMPDH, 3HPMPDH, 4HPMPDH and their Cu+2 and Zn+2 metal complexes showed more successful inhibition against standard drugs, based on structure activity relationship.

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Design, Synthesis and Spectroscopic Characterizations of Medicinal Hydrazide Derivatives and Metal Complexes of Malonic Ester

Parveen

Naseem

Shah

et al. 2023

CBC

View full text Add to dashboard Cite

show abstract

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Comparative Studies of New Complexes Synthesized by Chemical and Tribochemical Reactions Derived from Malonic Acid Dihydrazide (L; MAD) with Cu<sup>2+</sup> and Co<sup>2+</sup> Salts

Cited by 1 publication

References 14 publications

Design, Synthesis and Spectroscopic Characterizations of Medicinal Hydrazide Derivatives and Metal Complexes of Malonic Ester

Design, Synthesis and Spectroscopic Characterizations of Medicinal Hydrazide Derivatives and Metal Complexes of Malonic Ester

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