Comparative studies of potential cancer biomarkers carbon-11 labeled MMP inhibitors (S)-2-(4′-[11C]methoxybiphenyl-4-sulfonylamino)-3-methylbutyric acid and N-hydroxy-(R)-2-[[(4′-[11C]methoxyphenyl)sulfonyl]benzylamino]-3-methylbutanamide

Molecular Imaging of the Cardiac Extracellular Matrix

“…As with many imaging agents, the proof of principle of imaging of MMPs was obtained in tumors. [81][82][83][84][85][86][87] Substantial studies with MMP imaging have been undertaken in the imaging of atherosclerotic plaques wherein the MMPs have been implicated in plaque instability and fibrous cap thinning. Schäfers et al reported the feasibility of MMP imaging using 123 I-labeled broad-spectrum MMP inhibitor (CGS 27023A) in a carotid ligation model of atherosclerosis in ApoE −/− mice.…”

“…Schäfers et al reported the feasibility of MMP imaging using 123 I-labeled broad-spectrum MMP inhibitor (CGS 27023A) in a carotid ligation model of atherosclerosis in ApoE −/− mice. 88 This probe was also labeled with C-11 81 and F-18 89 to allow PET imaging; the results, however, remain preliminary. A broad-spectrum MMP inhibitor has also been labeled with a SPECT tracer ( 99m Tc-RP805).…”

Clinical applications for dual energy CT versus dynamic contrast enhanced CT in oncology

“…Owing to the short half-life of [ 15 O] of only a few seconds, on-site synthesis with a cyclotron and dedicated radiochemistry units is mandatory [9]. Beside functional information, e.g., on tumor perfusion, it is of interest to detect molecular markers that are highly expressed on the endothelium of tumor vasculature, such as VEGF and its receptors [10], integrins [11] and matrix metalloproteinases [12]. Here, modern PET tracers or innovative MR contrast agents play an important role.…”

PET and SPECT Imaging of Tumor Vasculature

“…Various 18 F and 11 C labeled MMPIs have 135 However, in vivo microPET study with 11 C-CGS 25966 failed to demarcate MMP-positive tumors. 136 A 11 C-labeled MMPI, (2R)-2-[[4-(6-fluorohex-1-ynyl)phenyl]sulfonylamino]-3-methylbutyric acid 11 C-methyl ester ( 11 C-FMAME), has also been synthesized and applied to two animal models of breast cancer, i.e. MCF-7 xenograft transfected with IL-1 and MDA-MB-435 xenograft in athymic mice.…”