Comparative studies of the circulating lipoproteins in hamster (Mesocricetus auratus) with a normal or spontaneous high level of cholesterol in the plasma

Sicart, R.; Sablé-Amplis, R.; Guiro, Amadou Tidiane

doi:10.1016/0300-9629(84)90587-5

Cited by 20 publications

(13 citation statements)

References 19 publications

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“…On the other hand in comparison of different organs and tissues in some animal species, liver did not contain the highest cholesterol level in all cases (Park et al, 1991). The liver cholesterol level in our C rabbits was comparable to that in hamsters with normal level of cholesterol in the plasma and in our E rabbits was comparable to that in hamsters with spontaneous high level of plasma cholesterol (Sicart et al, 1984). Hypercholesterolemia is generally recognized as a risk factor for the atherosclerosis in several species (Tsuda et al, 1983;Remy,1993;van Ree et al, 1994).…”

Section: Discussionsupporting

confidence: 51%

Effect of feeding cholesterol-enriched diet on plasma and tissue cholesterol and atherosclerosis in rabbits

Konecka¹,

Jezierski²,

Wnuk³

1996

J. Anim. Feed Sci.

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The aim of the experiment was to investigate the relationship between consumption of cholesterolenriched diet and plasma and tissue cholesterol content as well as the degree of atherosclerosis in rabbits, to make further investigations on the role of emotional and behavioural factors in diet induced atherosclerosis more conclusive. The experimental rabbits (E) were offered 150 g standard pellet feed daily mixed with 1 egg yolk and 1.5 g cholesterol in substantia during 7 weeks, whereas the control rabbits (C) were fed the same amount of feed without egg yolk and supplementary cholesterol. Significant effect of diet type on total plasma cholesterol, HDL-cholesterol (high density lipoprotein cholesterol) and cholesterol content in liver, heart and muscle was found. However negative correlations between cholesterol food consumption and total plasma cholesterol (r =-0.24) and atherosclerosis (r = -0.40) were found in group E. The relative increase of total plasma cholesterol in E group was greater than that of plasma HDL-cholesterol. Females demonstrated significantly higher total plasma cholesterol and HDL-cholesterol than males. The degree of atherosclerosis was positively correlated with the total plasma cholesterol (r=0.73, P<0.01) and plasma HDL-cholesterol concentration (r = 0.29) but negatively correlated with ratio HDL/total cholesterol (r = -0.66, P<0.01) as estimated after the end of the experiment.

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Section: Discussionsupporting

confidence: 51%

Effect of feeding cholesterol-enriched diet on plasma and tissue cholesterol and atherosclerosis in rabbits

Konecka¹,

Jezierski²,

Wnuk³

1996

J. Anim. Feed Sci.

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“…To the best of our knowledge, the mechanism of the fructose-induced elevation of HDL cholesterol has not previously been studied. Although hamsters do have cholesteryl ester transfer protein (38), one major difference between rodents and humans is that rodents carry a greater proportion of their total plasma cholesterol in the HDL rather than in the LDL fraction (40). Human studies (41,42) have shown that nutritional interventions such as high-fat feeding induce insulin resistance with an elevation of HDL cholesterol and apoA-1 production, whereas a reduction of apoA-1 production occurs when the diet is switched from high to low fat.…”

Section: Discussionmentioning

confidence: 99%

Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone

et al. 2004

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Postheparin plasma hepatic lipase (HL) activity has been shown to correlate with features of the metabolic syndrome and type 2 diabetes in humans. We examined HL postheparin plasma enzyme activity, hepatocyte mRNA, and protein mass in the insulin-resistant, fructose-fed Syrian golden hamster, and the response of the insulin-sensitizing peroxisome proliferator-activated receptor-␥ agonist rosiglitazone. Male Syrian golden hamsters were treated for 5 weeks with 1) normal diet (DIET group), 2) 60% fructose diet (FRUC group), or 3) 60% fructose and rosiglitazone (20 mmol ⅐ kg ؊1 ⅐ day ؊1 ) (FRUC؉RSG group). Hepatocyte HL mRNA, protein mass, and postheparin plasma HL activity were increased in FRUC compared with DIET hamsters. FRUC؉RSG hamsters had partial normalization of HL mRNA, mass, and activity. There was a shift in the size of LDL particles from large to small in FRUC animals and a shift back to large LDL size in FRUC؉RSG. This is the first demonstration that HL hepatocyte mRNA, mass, and plasma enzymatic activity increase concomitantly with induction of an insulin-resistant state and can be partially normalized by treatment with an insulin sensitizer. The increase in HL in insulin-resistant states may play an important role in the typical dyslipidemia of these conditions, and reduction of HL could explain some of the beneficial effects of insulin sensitizers on the plasma lipid profile.

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“…We have had the opportunity to under take such investigations in a colony of ham sters which spontaneously develop high lev els of cholesterol in plasma and in the liver with aging [4], These hamsters were named FEC hamsters. The rise in plasma choles terol is reflected by an elevated cholesterol content in the three major lipoprotein frac tions, but only the compostion of the VLDL is altered, the percentage of esterified choles terol being doubled [5]. Moreover, the accu mulation of cholesterol in the liver is accom panied by a reduction of bile acid in the bile stored in the gallbladder or in the bile col lected continuously in fistulated animals [6].…”

Section: Introductionmentioning

confidence: 94%

Reduction of Cholesterol Transported in Apo B-Rich Lipoproteins in Spontaneously Hypercholesterolemic Hamsters Fed an Apple-Supplemented Diet

Sicart¹,

Sablé-Amplis²

1987

Ann Nutr Metab

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The influence of an apple-supplemented diet on the distribution of cholesterol among the lipoproteins in plasma was studied using a special animal model: FEC hamsters which spontaneously develop hypercholesterolemia with aging when fed a commercial balanced diet. This metabolic disorder did not occur in animals freely consuming apples in addition to the standard diet. This combined diet essentially decreased the cholesterol content in the VLDL and LDL, the apo B-rich lipoproteins in plasma.

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Comparative studies of the circulating lipoproteins in hamster (Mesocricetus auratus) with a normal or spontaneous high level of cholesterol in the plasma

Cited by 20 publications

References 19 publications

Effect of feeding cholesterol-enriched diet on plasma and tissue cholesterol and atherosclerosis in rabbits

Effect of feeding cholesterol-enriched diet on plasma and tissue cholesterol and atherosclerosis in rabbits

Hepatic Lipase mRNA, Protein, and Plasma Enzyme Activity Is Increased in the Insulin-Resistant, Fructose-Fed Syrian Golden Hamster and Is Partially Normalized by the Insulin Sensitizer Rosiglitazone

Reduction of Cholesterol Transported in Apo B-Rich Lipoproteins in Spontaneously Hypercholesterolemic Hamsters Fed an Apple-Supplemented Diet

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