Comparative studies on the effect of adrenocorticotrophic hormone (ACTH) and pregnenolone-16α-carbonitrile (PCN) upon drug response and distribution in rats

Szabó, Sándor; Selye, Hans; Kourounakis, Panos N.; Taché, Yvette

doi:10.1016/0006-2952(74)90573-5

Cited by 8 publications

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“…The material to be presented in this review is mostly that of my Ph.D. thesis (University of Montreal) and is based partly on our previous publications 1974a;1975b;Kourounakis, et al, 1973d). It also includes the following new contributions (1) effect of pretreatment with various fragments of the ACTH molecule on zoxazolamine paralysis, (2) influence of an "antiglucocorticoid" on the action of glucocorticoids upon zoxazolamine paralysis, (3) hepatic ultrastructural changes produced by PCN and/or ACTH, (4) determination of the amount of bound and free zoxazolamine in plasma and the urinary and biliary excretion of the drug after ACTH-pretreatment, (5) effect of ACTH upon zoxazolamine paralysis in rats with partial hepatectomy, bile duct-ligation or nephrectomy, (6) endeavor to clarify and interpret the mechanism(s) of action of ACTH upon zoxazolamine paralysis.…”

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Effect of ACTH, corticoids and PCN (pregnenolone-16α-carbonitrile) on drug responses and disposition

Szabó¹

1979

Acta Endocrinologica

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The endocrine system plays an important role in the adaptation of the organism to environmental stimuli: it influences both specific and nonspecific responses. The ,,emergency reaction" and the ,,stress syndrome" were recognized a long time ago, but they remain very complex processes. Elucidation of their mechanism(s) of action is difficult, and the importance of individual hormones is not yet clearly understood. extracts and corticosterone, but not by DOC (Jensen & Grattan, 1940).

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confidence: 99%